RESUMO
A 50-year-old female presented with a five months history of recurrent attacks of dizziness, sweatiness, tremors and fainting with loss of consciousness. These were found to be due to hypoglycaemic episodes with blood sugars less than 1 mmol/l and were treated as such. A diagnosis of insulinoma was initially considered, but the patient turned out to have fibrosarcoma of the lung, a rare lung tumour. She also had finger and toe clubbing and features of hypertrophic pulmonary osteoarthropathy.
Assuntos
Fibrossarcoma/complicações , Fibrossarcoma/diagnóstico , Hipoglicemia/etiologia , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico , Osteoartropatia Hipertrófica Secundária/etiologia , Diagnóstico Diferencial , Feminino , Fibrossarcoma/cirurgia , Humanos , Neoplasias Pulmonares/cirurgia , Pessoa de Meia-IdadeAssuntos
Panencefalite Esclerosante Subaguda/epidemiologia , Encéfalo/microbiologia , Criança , Humanos , Imunossupressores/uso terapêutico , Quênia , Masculino , Vírus do Sarampo/isolamento & purificação , Panencefalite Esclerosante Subaguda/imunologia , Panencefalite Esclerosante Subaguda/microbiologiaRESUMO
The adult nephrotic syndrome as met with in Nairobi is predominantly encountered in young sophisticated African women, most of whom began to use skin-lightening creams containing mercury before the symptomatic onset of their illness. The particular form of mercury involved is well known to cause the nephrotic syndrome in other circumstances-for example, when applied to the skin in the treatment of psoriasis. In these circumstances the pathogenetic mechanism is thought to be of an idiosyncratic type. The use of mercury-containing skin-lightening creams in the patients studied seemed to be particularly associated with a "minimal-change" ("light-negative") renal glomerular lesion, this lesion being present in half of the patients. The prognosis in this group of patients seems remarkably good, with 50% entering remission, 77% of these doing so spontaneously on discontinuing the use of the creams.