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1.
J Gerontol A Biol Sci Med Sci ; 59(11): 1195-9, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15602075

RESUMO

Consistent with the compression-of-morbidity hypothesis, several studies have reported that a significant proportion of centenarians delay or escape age-related diseases. Of those who live with such diseases for a long time, many appear to do so with better functional status than do younger persons who do not achieve extreme old age. The authors describe the first autopsy in an Okinawan-Japanese centenarian who escaped many age-related illnesses and delayed frailty toward the end of her very long life. Her late-life morbidity pattern is contrasted with that of white centenarians.


Assuntos
Envelhecimento/patologia , Longevidade , Idoso , Idoso de 80 Anos ou mais , Autopsia , Broncopneumonia/patologia , Feminino , Humanos , Japão
2.
Acta Cytol ; 47(4): 663-7, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12920763

RESUMO

BACKGROUND: Intracytoplasmic lumina (ICL) have been observed frequently in breast carcinoma cells. However, they are extremely rare in thyroid gland tumors. We encountered a medullary carcinoma of the thyroid (MCT) with ICL and present a case with cytologic, immunocytochemical and ultrastructural features. CASE: A 15-year-old female was admitted with a left thyroid mass. Ultrasound examination revealed a well-defined tumor in the left lobe of the thyroid. Fine needle aspiration cytology showed mainly dispersed spindle cells with oval nuclei and some polymorphic or triangular tumor cells. The tumor cells containing ICL were noted at high magnification. The ICL contained sparse microvilli and abundant granular material with dense, round bodies on ultrastructural sections. Immunocytochemically, these tumor cells were positive for calcitonin and carcinoembryonic antigen (CEA). Moreover, CEA was recognized in the ICL with immunocytochemical staining. All tumor cells were negative for thyroglobulin. Pathologic examination confirmed the diagnosis of medullary carcinoma of the thyroid gland. CONCLUSION: MCT can include ICL with granular material containing CEA.


Assuntos
Carcinoma Medular/patologia , Citoplasma/patologia , Células Epiteliais/patologia , Corpos de Inclusão/patologia , Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/patologia , Adolescente , Calcitonina/metabolismo , Antígeno Carcinoembrionário/metabolismo , Carcinoma Medular/diagnóstico por imagem , Citoplasma/ultraestrutura , Células Epiteliais/ultraestrutura , Feminino , Humanos , Imuno-Histoquímica , Corpos de Inclusão/ultraestrutura , Microscopia Eletrônica , Glândula Tireoide/ultraestrutura , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Ultrassonografia
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