1.
J Chromatogr A
; 871(1-2): 181-8, 2000 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10735298
RESUMO
The chiral separation of lorazepam was achieved on a chiral column with UV and circular dichroism (CD) detection. The good resolution of lorazepam enantiomers was obtained on the column of beta-cyclodextrin derivative immobilized silica gel under reversed-phase conditions. The enantiomeric separation and identification of lorazepam were succeeded by CD detector. The method described allows the quantitation of the stereoisomers of lorazepam in human plasma following the administration of a therapeutic dose of the racemic drug. Chiroptical detection is useful for the pharmacokinetic study of chiral drugs.
Assuntos
Ansiolíticos/sangue , Cromatografia Líquida/instrumentação , Moduladores GABAérgicos/sangue , Lorazepam/sangue , Ansiolíticos/química , Dicroísmo Circular , Moduladores GABAérgicos/química , Humanos , Lorazepam/química , Sensibilidade e Especificidade , Estereoisomerismo
2.
Sanfujinka No Jissai
; 21(2): 131-42, 1972 Feb.
Artigo
em Japonês
| MEDLINE
| ID: mdl-5067089