The impact of diabetic polyneuropathy on toe grip strength in patients with type 2 diabetes mellitus: a cross-sectional study.

Purpose: Type 2 diabetes mellitus (T2DM) and concomitant diabetic polyneuropathy (DPN) induce muscle weakness. Muscle weakness in the foot is associated with foot deformities and falls. However, factors affecting toe grip strength (TGS) are not well known. Therefore, the present study investigated factors related to TGS in patients with T2DM. Methods: This was a cross-sectional study involving 100 patients with T2DM who were hospitalized for the treatment of T2DM and 50 healthy adults. The subjects were divided into three groups: a group of healthy subjects, a group of T2DM patients without DPN, and a group of T2DM patients with DPN. Hierarchical multiple regression analysis was performed with TGS and the TGS-to-weight ratio (TGS/Wt%) as dependent variables and with age, the presence of T2DM, and DPN as independent variables, and sex and BMI as confounders. Results: There were no significant differences in age or sex among the three groups. In the final regression analysis, age and presence of T2DM and DPN were associated in both models with TGS and TGS/Wt% as dependent variables. Conclusion: DPN, T2DM, and age were found to be related to TGS. The findings of this study could contribute to healthcare providers developing foot care and rehabilitation programs for diabetic patients. Trial registration: This study was registered with UMIN-CTR (UMIN000034320) on 1 November 2018.

Effectiveness of impedance parameters for muscle quality evaluation in healthy men.

We investigated the relationship between impedance parameters and skeletal muscle function in the lower extremities, as well as the effectiveness of impedance parameters in evaluating muscle quality. Lower extremity impedance of 19 healthy men (aged 23-31 years) measured using the direct segmental multi-frequency bioelectrical impedance analysis were arc-optimized using the Cole-Cole model, following which phase angle (PA), [Formula: see text], and ß were estimated. Skeletal muscle function was assessed by muscle thickness, muscle intensity, and isometric knee extension force (IKEF). IKEF was positively correlated with PA (r = 0.58, p < 0.01) and ß (r = 0.34, p < 0.05) was negatively correlated with [Formula: see text] (r = - 0.43, p < 0.01). Stepwise multiple regression analysis results revealed that PA, ß, and [Formula: see text] were correlated with IKEF independently of muscle thickness. This study suggests that arc-optimized impedance parameters are effective for evaluating muscle quality and prediction of muscle strength.

Changes in neck muscle thickness due to differences in intermittent cervical traction force measured by ultrasonography.

[Purpose] Many patients receive intermittent cervical traction in a daily treatment setting. However, unified settings for traction force, duration, and direction have yet to be determined. Therefore, an objective index is required to determine changes in traction conditions or to indicate its effectiveness. [Subjects] Fifteen healthy males volunteers participated in this study. [Methods] The thickness of the trapezius and splenius capitis muscles before and during traction were measured using ultrasonography at three traction forces: 5, 8 and 11 kg. [Results] Significant differences in muscle thickness were observed at 11 kg in the trapezius, and at 8 kg and 11 kg in the splenius capitis muscles. The muscle thickness ratio of the trapezius muscle showed a significant difference between 11 kg and 5 and 8 kg, and between 5 kg and 8 and 11 kg, as well as between 8 kg and 11 kg for the splenius capitis muscles. [Conclusion] Differences in muscle direction between the trapezius and splenius capitis muscles may account for the contrasting results obtained at the 8 kg traction force. This finding suggests that cervical traction must be performed considering the effects on different neck regions.

Changes in the lactate threshold during treadmill exercise after microsphere-induced infarction in rats.

The aim of this study was to clarify changes in the lactate threshold (LT) in the acute period after cerebral infarction. Cerebral infarction was induced by the injection of microspheres (MS) into the right internal carotid artery. To estimate the degree of neurologic deficit caused by surgery, the behaviors of all rats were evaluated in terms of typical symptoms of stroke in rats. The rotarod test was used to evaluate equilibrium function. Rats were forced to perform stepwise treadmill exercises, and serial changes in blood lactate concentration were measured for determination of the LT. The average treadmill speed at the LT and the rotarod test performance in MS rats was significantly lower than those in sham-operated rats on postsurgery day 2. However, although neurologic deficits disappeared on postsurgery day 7 in MS rats, LT level and rotarod test performance were significantly lower than in sham-operated rats. These results suggest that the decrease in LT in the acute period after cerebral infarction might be induced by impaired equilibrium function. Other possibilities are discussed as well.