Assuntos
Fertilização , Hiperêmese Gravídica/prevenção & controle , Minerais/administração & dosagem , Náusea/prevenção & controle , Pré-Medicação , Vertigem/prevenção & controle , Vitaminas/administração & dosagem , Feminino , Humanos , Recém-Nascido , Avaliação Nutricional , Gravidez , Primeiro Trimestre da Gravidez , Método Simples-CegoAssuntos
Anti-Inflamatórios não Esteroides/administração & dosagem , Piroxicam/análogos & derivados , Polimialgia Reumática/tratamento farmacológico , Atividades Cotidianas , Anti-Inflamatórios não Esteroides/efeitos adversos , Anti-Inflamatórios não Esteroides/uso terapêutico , Ensaios Clínicos como Assunto , Método Duplo-Cego , Esquema de Medicação , Humanos , Piroxicam/administração & dosagem , Piroxicam/efeitos adversos , Piroxicam/uso terapêuticoRESUMO
The effect of indomethacin (2 X 50 mg daily) and carprofen (2 X 150 mg daily) on gastric secretion and the generation of prostaglandins PGE2 and PGF2 alpha in gastric juice, was investigated in a single blind cross-over study in eight healthy volunteers lasting one week. We observed no statistically significant change in basal and pentagastrin-stimulated gastric secretory parameters (outputs of gastric acid, N-acetyl-neuraminic acid and pepsin) before and after treatment with indomethacin and carprofen. However, an inhibitory effect was found on the output of PGE2 and PGF2 alpha after pentagastrin stimulation. While both drugs diminished the output of PGF2 alpha to a similar extent, carprofen exerted a markedly weaker inhibitory effect on the output of PGE2 than did indomethacin. It is suggested that the gastric tolerability of non-steroidal anti-inflammatory drugs (NSAIDs) is related to their inhibitory potency on PGE2 formation, in the sense that weak inhibitors of PGE2 cause less damage to the gastric mucosa than do strong inhibitors.
Assuntos
Carbazóis/efeitos adversos , Mucosa Gástrica/efeitos dos fármacos , Indometacina/efeitos adversos , Adulto , Dinoprosta , Dinoprostona , Suco Gástrico/efeitos dos fármacos , Suco Gástrico/metabolismo , Mucosa Gástrica/fisiologia , Humanos , Masculino , Prostaglandinas E/metabolismo , Prostaglandinas F/metabolismoRESUMO
The effect of indometacin (3 X 50 mg daily), carprofen (Imadyl) (2 X 150 mg daily) and placebo (3 X daily) on gastric juice secretion, acidity, prostanoid concentration (PGE2, PGF2 alpha and TXB2) and excretion of the major urinary metabolite of PGF (PGF-MUM) were investigated in a single-blind cross-over study in nine healthy volunteers after 3-day treatment periods separated by one-week washout periods between treatments. Indometacin proved to be a classical cyclooxygenase inhibitor (strong inhibition of PGE2 and TXB2 before and after pentagastrin stimulation and of PGF-MUM) while carprofen was an atypical inhibitor (weak inhibition of PGE2 before pentagastrin stimulation and no inhibition after, strong inhibition of TXB2 but without influence on PGF-MUM). The weak inhibition of PGE2-biosynthesis by carprofen might be related to its low incidence of gastric side effects.
