[HIV-associated lymphoma -- an unusual cause of pathological mandibular fracture]. / HIV-assoziiertes Lymphom -- ungewöhnliche Ursache einer pathologischen Unterkieferfraktur. Fallbericht und Behandlungsoptionen bei Immundefizienz.

Despite the introduction of highly active antiretroviral therapy (HAART), diffuse large B-cell lymphoma (DLBCL) remains a common malignancy in human immunodeficiency virus (HIV)-infected patients, especially the plasmablastic variant. About 50% of lymphomas in HIV patients are extranodal and half of them occur in the head and neck area. The main oral symptoms are pain, swelling, numbness and tooth mobility. We report the case of a 52-year-old patient with a known HIV infection and fracture of the angular region of the mandible. The fracture did not unite following open reduction and osteosynthesis. A biopsy performed at the time of revision revealed the diagnosis of a primary lymphoma in the mandible. After chemotherapy had induced complete remission of the lymphoma and autogenous iliac crest bone grafting had been performed the fracture united. Primary lymphoma in the mandible is a disease that presents with a nonspecific radiological appearance which may mimic osteomyelitis or periodontal pathology. A rapid and accurate diagnosis is critical for the appropriate treatment. In our experience HIV-positive patients with mandibular fracture should be treated according to the guidelines established for HIV-negative patients. However, risky compromises such as intraoral approach or hazardous fracture fixation should be avoided.

[Antibodies in gamma-globulin preparations (author's transl)]. / Der Gehalt an Antikörpern gegen Viren in einigen Gammaglobulinpräparaten

A commerical preparation of gamma-globulin with 16% protein content for i. m. administration, as well as two commercial preparations of 5% protein content for i.v. administration, were tested for their antibodies to different viruses. The highest antibody titres were found in the 16% gamma-globulin. Sufficient levels of antibodies to justify prophylactic use were demonstrated in the case of rubella, measles, polio and EBV, whilst antibodies to mumps, coxsackie A9, B1-5 and herpes simplex type I and II were present to a moderate degree. Only low concentrations of antibodies or none at all were found with respect to influence A and B, para-influenza 1--3, vaccinia, adeno 3 and 7, and echo 4, 6, 9, 18 and HBs-antigen. This study shows that normal gamma-globulin can be used prohylactically against many different viral diseases.