RESUMO
N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc-N-(2-bromo-5-methoxyphenylmethyl) methacrylamides. The structure and activity relationship of these derivatives are examined.
Assuntos
Benzazepinas/síntese química , Movimento Celular/efeitos dos fármacos , Acrilamidas , Alquilação , Benzazepinas/química , Benzazepinas/farmacologia , Linhagem Celular , Ciclização , Células Epiteliais/efeitos dos fármacos , Humanos , Pele/citologia , Relação Estrutura-Atividade , Cicatrização/efeitos dos fármacosRESUMO
Waste fiber-reinforced plastics (FRPs), which are formidable composite plastics for chemical treatment, can be efficiently depolymerized by treatment with supercritical methanol in the presence of catalytic amounts of 4-(dimethylamino)pyridine (DMAP), which is a well-known catalyst for the formation of esters and amides. This novel depolymerization reaction also provides ready separation of the depolymerized products into three components: methanol-soluble oil, CHCl3-soluble solid, and an inorganic residue. Thus, almost complete decomposition of FRP as well as useful separation of the decomposed products was achieved with the present method, and the latter were ready for chemical recycling. Investigation of the reaction profile revealed that the reaction rate increased as the amount of DMAP increased. Unfortunately, DMAP employed in the reaction could not be recovered because of its decomposition catalyzed by dimethyl phthalate, a depolymerized product from waste FRP, under the reaction conditions employed.
Assuntos
Vidro/química , Plásticos/química , Piridinas/química , Eliminação de Resíduos/métodos , Metanol/química , Microscopia Eletrônica de Varredura , Solubilidade , Propriedades de SuperfícieRESUMO
Re-epithelialization is an important event in the healing of skin wounds. We have now shown that a 2-benzazepine derivative, N-(2,2,2-trifluoroethyl)-8-methoxy-4-methyl-2-benzazepin-3-one (compound A), facilitated the migration of human keratinocyte HaCat cells in an in vitro model of wound healing and inhibited the attachment of these cells to a collagen matrix. Topical application of compound A also promoted the healing of skin wounds in mice. Our results suggest that compound A promotes the repair of skin wounds by facilitating epithelial cell migration and that this 2-benzazepine derivative is a potential new drug for the treatment of such wounds.
