RESUMO
Recent studies have demonstrated that the cysteinyl-leukotriene1 receptor (CysLT1R) antagonist induces the growth arrest of cancer cells through apoptosis. In this study, we examined the effects of the CysLT1R antagonist on cell proliferation in urological cancer cell lines, including renal cell carcinoma, bladder cancer, prostate cancer and testicular cancer cells. The inhibitory effect of the CysLT1R antagonist on the urological cancer cells was investigated using the MTT assay and flow cytometry. The CysLT1R antagonist induced a reduction in cell viability with a half-maximal concentration of growth inhibition in all the urological cancer cell lines, and arrested the growth of the cells through early apoptosis. In conclusion, the CysLT1R antagonist may mediate potent anti-proliferative effects against urological cancer cells through early apoptosis, and may therefore serve as a novel therapeutic target in the treatment of urological cancer.
RESUMO
A questionnaire study was conducted on sexual life such as intercourse frequency, libido and erectile function and degree of satisfaction of sexual life in aging couples. Half of them had sexual intercourse and satisfaction of life. According to multivariate analysis using stiffness of penis at erection, erection maintained, and difficulty of maintenance of erection state, there was a significant relationship between satisfaction of sexual life and frequency of erection maintained or difficulty of maintenance of erection state, and also between confidence on erection and difficulty of maintenance of erection state. These values became lower because of aging. We concluded that sexual communication was needed in the life of aging couples, and an urologist should have a role in consulting on aging life.
