[Metabolic correction of neurochemical disturbances in the striatum by the amino-acid-based drug tavamin on the experimental model of morphine abstinence syndrome].

We have studied the content of neuroactive amino acids in the striatum of rats under the conditions of development of the morphine abstinence syndrome, as well as the possibility of its metabolic correction by amino-acid-based drug tavamin. Peculiarities in the metabolism of glutamate, aspartate, glycine, GABA, and taurine in addicted rats and the effect of tavamin on the background of abstinence syndrome have been revealed.

[The neurotropic properties of new 4,4-di-substituted derivatives of 1-methylpiperidine]. / Neirotropnye svoistva novykh 4,4-di-zameshchennykh proizvodnykh 1-metilpiperidina.

Experiments on small laboratory animals were made to study local anesthetic, antinociceptive and antihypoxic properties of 6 new derivatives of 1-methylpiperidine. A substance coded phi AB-8 (1-methyl-4-vinylethynil-4-benzoyl hydroxypiperidine hydrochloride) was found to exert a pronounced local anesthetic and an antihypoxic actions.

[Pharmacological activity of cytochrome C]. / Farmakologicheskaia aktivnost' tsitokhroma C.

Cytochrome C (a single dose range of 1-200 mg/kg, intraperitoneally) does not possess the antihypoxic activity (altitude chamber, methemoglobinemia, circulatory hypoxia), decreases (in a dose of 50 mg/kg) diuresis in rats modifying diversely (depending on the dose used) the hypnotic effects of general anesthetics and the convulsant activity of corazol and arecoline.