RESUMO
The elixir Bronchofit is an aqueous-alcoholic extract from 7 kinds of plants. It is a balanced compound, rich in biologically active substances including essential oils and flavonoids, possessing a wide spectrum of pharmacological activity. On the model of frog's palate the elixir enhanced the transport function of the ciliated epithelium. On the model "karragenin edema" bronchofit showed a marked anti-inflammatory activity. A noticeable therapeutic effect was registered in rats with induced bronchopulmonary inflammation. Bronchial secretion contained reduced content of glycosaminoglycans while bronchial lavage did of histamine. Also, bronchofit demonstrated a prominent antioxidative activity, an antibacterial action in relation to Str. pyogenes and Bac. cereus. By a total complex of the activities bronchofit is a promising medicine against bronchopulmonary inflammation.
Assuntos
Anti-Inflamatórios/farmacologia , Broncopneumonia/tratamento farmacológico , Extratos Vegetais/farmacologia , Animais , Anti-Infecciosos/farmacologia , Anuros , Líquido da Lavagem Broncoalveolar , Broncopneumonia/prevenção & controle , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos/métodos , Epitélio/efeitos dos fármacos , Glicosaminoglicanos/metabolismo , Histamina/metabolismo , Técnicas In Vitro , Masculino , Camundongos , Testes de Sensibilidade Microbiana , Palato/citologia , Palato/efeitos dos fármacos , RatosRESUMO
Prolactine was found to promote neurite extension in chick embryo dorsal root ganglia in vitro. This hormone was active at the concentration 10-50 ng/ml provided extensive neurite outgrowth in the bioassay, compared to the control. The liquor from patients with prolactinoma was also found to promote neurite extension. This fact may be used for prolactinoma diagnostics.