RESUMO
The present experiments were designed to test the hypothesis that the increase in plasma potassium which occurs during exercise acts as a stimulus to respiration via the peripheral chemoreceptors. The effect of intravenous infusion of KCl on ventilation was measured in anaesthetised cats while they were loaded with CO2 intravenously via a bubble gas exchanger. Ventilation during K+ infusion was compared with that immediately before in 'intact' and peripherally chemodenervated cats. In the 'intact' group there was a highly significant increase in ventilation of approximately 25% (+253 +/- 22 ml/min, P less than 0.001), whereas in the chemodenervated group there was no significant change (+ 17 +/- 11 ml/min) in spite of similar increases in arterial K+ concentration. The results of these experiments indicate that K+ infusions stimulate ventilation and that this effect is abolished by peripheral chemodenervation.
Assuntos
Denervação , Nervos Periféricos/fisiologia , Potássio/farmacologia , Respiração/efeitos dos fármacos , Animais , Artérias , Dióxido de Carbono/sangue , Gatos , Concentração de Íons de Hidrogênio , Lidocaína , Potássio/sangueRESUMO
Two anaesthetic techniques were assessed in 120 fit young women having non-emergency gynaecologial laparoscopy as in-patients. One group breathed halothane spontaneously via a face mask, and the second group were given neuromuscular blocking drugs and ventilation was controlled. There was no significant difference in intraoperative anaesthetic or surgical complications between the two groups although morbidity was greater in the intubated group when assessed 4 h after surgery. After 24 h there was no difference in postoperative morbidity. In an appendix to the study, 40 day-stay patients having the same operation under similar conditions were reviewed. After 24 h abdominal pain, lethargy and weakness were still present; 30% of the patients stated that they would prefer to be admitted overnight for a similar procedure in the future.
Assuntos
Anestesia Geral/métodos , Laparoscopia , Adolescente , Adulto , Procedimentos Cirúrgicos Ambulatórios , Anestesia por Inalação , Dióxido de Carbono/administração & dosagem , Dióxido de Carbono/sangue , Feminino , Halotano , Humanos , Complicações Intraoperatórias , Pessoa de Meia-Idade , Pancurônio , Pressão Parcial , Complicações Pós-Operatórias , Respiração , Respiração ArtificialRESUMO
A technique of general anaesthesia is described which has been used for trans-bronchial lung biopsy in 100 patients. Sixty-seven were day cases. An early pneumothorax was detected in four patients, but only one needed tube drainage.
