RESUMO
Magnesium oxide (MgO) nanoparticles were green synthesized using mahua (Madhuca longifolia) flower extracts by solvent evaporation and characterized by UV-visible spectroscopy, X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and Energy dispersive X-ray analysis (EDX). The drug loading of sumatriptan succinate (SS), an anti-migraine drug, was optimized using MINITAB's response surface methodology (RSM) Box Behnken model (BBD) model. The investigation of drug adsorption and release kinetics was further conducted using the optimized set obtained through RSM. The optimized parameters consisted of 23.53 mg of nanoparticles, a loading time of 6 h, and a pH of 9, yielding the experimental drug loading efficiency ~47%. The primary objective of this study is to investigate the potential of utilizing these green synthesized MgO nanoparticles for a dual purpose. The primary objective of this study is to investigate the viability of utilizing MgO nanoparticles synthesized through green route for the delivery of an anti-migraine medication. Additionally, the study aims to examine the degradation of these nanoparticles at physiological pH levels, with the intention of potentially enhancing cellular absorption. The investigation involved the assessment of drug release kinetics using various mathematical models, with a focus on the release of SS from MgO nanoparticles. This evaluation was conducted at different pH levels, specifically pH 5, 7, and 9. It has been found that the SS release increases as pH decreases, which is attributed to the dissolution of MgO nanoparticles, which therefore exhibits varied behavior at different pHs. The confirmation of the degradation of the green synthesized MgO nanoparticles was achieved through the execution of a degradation study, followed by the analysis of the obtained samples using FESEM and EDS. At neutral, the release data obtained adhered to the Higuchi model, which suggests that the release of the drug is based on diffusion. This finding is particularly advantageous for the controlled release of an anti-migraine drug. The results obtained from the study indicate that MgO nanoparticles have the potential to serve as a significant component in drug delivery systems, specifically as drug carriers. Attachment of SS over MgO nanoparticles to form SS loaded MgO nanoparticles and its possible working mechanism.
