[The effect of an agluten diet on cellular immunity in adult patients with celiac disease]. / Vliianie agliutenovoi diety na pokazateli kletochnogo immuniteta u bol'nykh tseliakiei vzroslykh.

A total of 45 patients with Gee's disease of adults were followed up in the time course of 6 months to 3 years. In untreated patients the number of T-lymphocytes was decreased both at the expense of T-helpers and, especially, of T-suppressors. Lymphokine-producing activity of T-lymphocytes, according to the production degree of the mediator, inhibiting monocyte adherence, increases after gliadin-treatment of the immuno-competent cells, that leads to monocyte adhesion decrease. In patients strictly keeping the agluten diet the cellular immunity parameters return to normal. Decreased monocyte adhesion remains up to a year. In those who do not strictly keep the agluten diet the cellular immunity disorders are retained and become more pronounced than in the untreated patients.

[State of regenerative processes in the mucosa of the small intestine in celiac disease in adults (gluten enteropathy)]. / Sostoianie protsessov regeneratsii slizistoi obolochki tonkoi kishki pri tseliakii vzroslykh (gliutenovoi énteropatii).

Biopsies of the small intestine mucosa were studied in 60 patients among which celiac disease was diagnosed in 35 after clinico-morphological examinations and chronic enteritis in 25. Apart from histological and histochemical methods, autoradiography of biopsies with 3H-thymidine was used. The study showed that atrophy of the small intestine mucosa in celiac disease in adults was of hyperregeneratory nature which was manifested by deepening of the crypts and increased number of DNA-synthesizing enterocytes. Due to enhanced proliferation incompletely differentiated cells appear on the villae which are incapable of completely performing the functions of membrane digestion and absorption. These enterocytes are histochemically similar with crypt epithelium and, like the latter, are more stable to autolysis. Functionally, the presence on the villae of incompletely differentiated epithelium is more significant than villi atrophy. Treatment with aglutenic diet eliminates the syndrome of disturbed absorption despite persisting atrophy. The processes of cell renewal become normalized as proved by the appearance of high epithelium on the villae and decreased label index.

[Late treatment results with a gluten-free diet in celiac disease in adults]. / Otdalennye rezul'taty lecheniia agliutenovoi dietoi bol'nykh tseliakiei vzroslykh.

The efficacy of the treatment with an agluten diet of celiac disease of the adults was studied in 45 patients over time, the observation periods ranging from 6 months to 6 years. The results were assessed from the patients' clinical examination that included study of absorption function of the small intestine (daily mass and fat loss with feces, absorption of D-xylose), determination of hemoglobin, total protein in blood serum, and morphological study of the jejunum mucosa obtained on aspiration enterobiopsy. Analysis of the data has shown that the patients who strictly observed the agluten diet noted a clinical remission with a tendency towards morphological improvement of the structure of small intestinal mucosa. No such an improvement was recorded in patients given gluten on a periodic basis.