[The Role of the I/D Polymorphism of the ACE Gene in the Development of Atrial Fibrillation].

OBJECTIVE: To study associations of I / D polymorphism of the ACE gene with risk of atrial fibrillation (AF) with the aim of detecting groups of patients prone to development of this disease. MATERIALS AND METHODS: We examined 90 probands with confirmed diagnosis of AF and 144 their I, II, III degrees relatives. These families constituted a core group of our study. The control group comprised 100 relatively healthy people without history of cardiovascular diseases. Methods used in all patients included clinical examination, electrocardiography, echocardiography, Holter ECG monitoring, veloergometry, transesophageal left atrial pacing, molecular-genetic tests. RESULTS: We found statistically significant predominance of genotype II homozygous carriers among probands with primary AF compared with the control group (30.0±7.2 % and 14.0±3.5 %, respectively; p=0.028). Homozygous carriers of DD genotype statistically significantly prevailed in the control group compared with group of probands with primary AF (36.0±4.8 % and 15.0 %±5.6 %; p=0.014). Carriers of homozygous genotype II for common allele statistically significantly prevailed among probands with secondary AF compared with the control group (34.0±6.7 % and 14.0±3.5 %, respectively; p=0.004). Homozygous carriers of DD genotype for the rare allele statistically significantly prevailed among control subjects compared to probands with secondary AF (36.0±4.8 % and 10.0 %±4.2 %, respectively; p=0.001). CONCLUSION: Thus, compared with controls statistically significant preponderance of carriers of homozygous genotype II for common allele was found among probands with both primary and secondary AF. At the same time compared with probands there was a statistically significant predominance of homozygous carriers of DD genotype for the rare allele in the control group. Our findings suggest the heterogeneous nature of AF and confirm that DD genotype homozygosity can be protective against the development of AF.

[Role of AGTR1 A/C polymorphism in the development of atrial fibrillation]. / Rol' polimorfizma A/C gena AGTR1 v razvitii fibrilliatsii predserdii.

AIM: To investigate the AGTR1 A/C polymorphism associated with atrial fibrillation (AF) to form risk groups among patients who are prone to this disease. SUBJECTS AND METHODS: 90 probands with a confirmed diagnosis of AF and their 144 first-, second-, and third-degree relatives were examined. These families made up a study group. A control group was formed of 100 apparently healthy individuals without a history of cardiovascular diseases. Collection of medical history data and complaints, electrocardiography, electrocardiogram monitoring, as well as molecular genetic analysis, thyroid hormone tests were done in all the patients. RESULTS: No statistically significant data on the correlation between the AGTR1 A/C polymorphism and the development of AF were obtained in any patient subgroup. The obtained results can be due to the genetic features of a Siberian population, which are dependent on climatic conditions and geographical location, and confirm that AF is a heterogeneous disease. CONCLUSION: There were no statistically significant differences between the patients in the study group and those in the control group. Our findings suggest the heterogeneity of AF and confirm its multifactorial nature.