RESUMO
The nutritive status features and the main parameters of nitrogen metabolism were investigated in 212 children with acute leukemia at varying stages of the disease. A study was made of the patients' body mass, nitrogen balance, excretion of nitrogenous compounds with urine and feces, total protein and albumin content in the blood, as well as blood content of urea, creatinine, amino nitrogen and uric acid. The results of the study have shown a negative influence of both leukemia and its therapy on the nutritive status of the patients, that was manifested in protein-energy deficiency and in protein assimilation disorders. A relationship has been revealed between infectious complications, preventing the successful treatment, and the nutritive status of the patients. Clarification of these pathogenetic mechanisms of the negative action of the disease itself and antileukemic therapy will help in the realization of the purposeful correction.
Assuntos
Proteínas Alimentares/metabolismo , Leucemia/metabolismo , Estado Nutricional , Doença Aguda , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Peso Corporal/efeitos dos fármacos , Criança , Proteínas Alimentares/efeitos dos fármacos , Feminino , Humanos , Leucemia/tratamento farmacológico , Masculino , Nitrogênio/urina , Estado Nutricional/efeitos dos fármacos , Indução de Remissão , Fatores de TempoAssuntos
Homeostase , Leucemia/terapia , Doença Aguda , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Criança , Terapia Combinada , Humanos , Leucemia/tratamento farmacológico , Leucemia/fisiopatologia , Indução de RemissãoRESUMO
A study was made of the content of ubiquinone, vitamins A, E, ascorbic, dehydroascorbic and diketogulonic acids (DKGA), and malonic dialdehyde (MDA) in the liver, of the content of glutathione, the activity of superoxide dismutase (SOD) and glutathione reductase in red blood cells, of the content of vitamins A, E and ubiquinone in the spleen of C57Bl/6jG mice with inoculated leukemia La. It was found that in red blood cells of the animals with leukemia, the content of vitamin E and DKGA reduced, the MDA level increased, and the content of glutathione dropped whereas SOD activity rose. Application of the antioxidant complex of vitamins A, E, C appreciably improved the characteristics of enzymatic and non-enzymatic antioxidant protection of the liver and red blood cells of the leukemic animals without exerting any noticeable effect on the content of vitamin E and ubiquinone in the leukemic spleen tissue.
