RESUMO
Antiviral activity of Gefin was studied in guinea pigs infected with herpes simplex virus (HSV-2). Up to 54.9% animals challenged with HSV survived after 7-day treatment with Gefin (3 local applications a day). The prospects of further trials of the drug in HSV genital herpes are discussed.
Assuntos
Antivirais/uso terapêutico , Foscarnet/uso terapêutico , Herpes Genital/tratamento farmacológico , Herpesvirus Humano 2 , Administração Tópica , Animais , Modelos Animais de Doenças , Cobaias , MasculinoRESUMO
Antiviral activity of a Russian drug foscarnet (tablets and coated pills) was assessed in guinea pigs with experimental genital herpes. New dosage forms were well tolerated by the animals, causing no manifest symptoms of intoxication irrespective of the doses or protocols of the drug use, Foscarnet in any dosage form in the total daily dose of at least 120 mg/kg had a pronounced antiviral effect towards herpes simplex type II virus, comparable with that of the commercial reference drug virolex: the intensity of clinical symptoms was alleviated and the disease duration shortened.