The Oral Mucosa Status and the Correlation between the Functional Parameters and the Level of Nitric Oxide Metabolites in Saliva among Patients with GERD.

The study involved 91 patients (48 women and 43 men), aged from 18 to 70 years with GERD. All patients underwent the clinical dental examination according to a single scheme including general clinical manifestations (nausea, single vomiting, belching, heartburn, pain in the epigastrium and around the navel, and poor appetite) and dental manifestations of GERD. The objective assessment of the dental status of the examined patients included the measurement of the functional parameters of the mixed saliva, buffer capacity (BC) of saliva, and the detection of the nitric oxide metabolites (NOx) content in saliva from the right parotid salivary gland ("SRPSG") and in blood serum using the indirect method based on the determination of the stable metabolites: nitrates and nitrites using the Griess reaction. It was established that salivation rate among patients with GERD with the prevailing of ACR and SACR was at the lower limit of normal values (0.32 + 0.19 ml/min), and the salivation rate among patients with the prevailing of SALCR was low (0.10 + 0.04 ml/min). The BC of saliva among patients with the prevailing of ACR and SACR was high (9.07 + 1.23 mmol eq/l and 9.40 + 1.71 mmol eq/l, respectively) and was reduced among patients with the prevailing of SALCR (7.63 + 0.18 mmol eq/l). The NOx level in SRPSG among patients with GERD was increased (especially in Group 3 (20.93 + 11.23 umol/l)). The direct correlation between the indicators of sialometry, the level of the BC of saliva, and the NOx level in SRPSG were established during the study.

[The Clinical Value of no-Reflow Phenomenon in the Routing Operation of The Regional Vascular Center].

Coronary no-reflow phenomenon (CNR) is a complication of primary percutaneous coronary intervention (PCI). According to different reports, CNR occurs in 10 to 60 % of cases. Despite the long history of studying this phenomenon many issues remain unsolved. This article presents a clinical case of electrocardiographically confirmed ST-segment elevation myocardial infarction. In this case, the CNR phenomenon occurred during PCI and was associated with heart rhythm disorders, left ventricular (LV) cavity dilatation with a decrease in LV contractility, and formation of intracavitary thrombus. The patient asked for medical care late, which could influence the development of CNR. This case demonstrates the clinical significance, diagnostic characteristics, and successful drug correction of the no-reflow phenomenon.

[Moscow Screening: Lung Cancer Screening With Low-Dose Computed Tomography].

For the first time in Moscow and Russia, a program of selective lung cancer screening has been implemented with a comprehensive approach, including organizational, management, medical, technical and educational aspects and quality control. Unique ultra-low-dose protocols (ultra-LDCT) have been developed to implement the screening program. These protocols allow performing high-quality chest computed tomography for lung nodule detection with an effective dose of less than 1 mSv. The possibility of using neural networks ("artificial intelligence") for quality control of screening results has been proven for the first time.

[Consensus resolution on a modern view on the therapeutic and prophylactic effect of individual oral care products containing fluoride]. / Rezoliutsiia Ékspertnogo soveta 'Sovremennyi vzgliad na lechebno-profilakticheskoe deistvie individual'nykh sredstv dlia ukhoda za polost'iu rta, soderzhashchikh ftoridy'.

The purpose of the publication was to present the materials of the Expert Council Consensus on 'A Modern View on the Treatment and Preventive Effect of Fluoride Containing Personal Oral Care Products', which took place on April 21, 2019 in Moscow (Russia) with the support of the pharmaceutical company JSC GlaskoSmitKlein Helsker. During the work of the expert council, a solution was developed for the safe use of fluoride-containing oral hygiene products as part of fluoride prevention of dental caries. In the real conditions of everyday life, it is advisable for dentists to: use local fluoride-containing agents to know the concentration of fluoride in drinking water and in areas with low and optimal levels of it; recommend fluorides for daily use in small concentrations, for example, for children from 2 years of age to brush their teeth twice a day with fluoride toothpaste for at least 3 minutes; children up to 6 years old, when brushing their teeth once, use no more than a pea-size piece of toothpaste with 500 ppm of fluoride; toothpastes with fluoride concentration from 500 to 5000 ppm should be admitted depending on the risk level of caries development; rinses with a fluoride concentration of 0.025-0.05% should be recommended for children from 6 years and adults twice a day for 1 minute after brushing teeth; for patients with a high risk of caries, periodically (from 2 to 6 times a year) to carry out applications with agents with high concentration of fluorides; for prolonging the effect of local fluorine-containing agents advise patients to refrain from eating and drinking for an hour after their use. Dentists should know the methods of fluoride use in dentistry, since fluoride prevention of caries should be an integral part of their therapeutic and preventive work.

[Sturge-Weber syndrome in children. Clinical features, diagnosis and approaches to therapy on the example of three clinical cases]. / Sindrom Shturge-Vebera u detei. Osobennosti kliniki, diagnostiki i podkhodov k terapii paroksizmal'nykh sostoianii na primere trekh klinicheskikh nabliudenii.

Sturge-Weber syndrome belongs to the group of phacomotoses and is characterized by a combined lesion of the skin, eyes, nervous system and internal organs. The clinical course of Sturge-Weber syndrome is quite diverse. Of particular interest in the practice of pediatric neurology and neurosurgery is the fact that 72-90% of patients present with epilepsy. Of particular difficulty is the differential diagnosis of epileptic seizures and stroke-like episodes. The article presents clinical cases of patients with Sturge-Weber syndrome of various ages with epileptic seizures and transient ischemic attacks.

In situ impedance spectroscopy of filament formation by resistive switches in polymer based structures.

It is shown that the impedance spectroscopy allows identification of the resistive switching mechanisms in complex composite structures. This statement was demonstrated on an example of organic based sandwich structures with a modified polymer matrix as an active element. The impedance spectroscopy scanning was performed for a series of intermediate states formed within the switching process. Analysis of the experimentally obtained impedance spectra shows that the electron transport is provided by delocalized charge carriers and proceeds via conducting filaments formed in a highly resistive matrix. The filament configuration changes during the switching. With the shift from isolating to conducting states, single isolated filaments are reorganized into a branched network.

Preliminary validation study of the Russian Birmingham Cognitive Screen.

INTRODUCTION: The Birmingham Cognitive Screen (BCoS) is designed for use with individuals who have acquired language impairment following stroke. Our goal was to develop a Russian version of the BCoS (Rus-BCoS) by translating the battery following cultural and linguistic adaptations and establishing preliminary data on its psychometric properties. METHOD: Fifty patients with left-hemisphere stroke were recruited, of whom 98% were diagnosed with mild to moderate aphasia. To check whether the Rus-BCoS provides stable and consistent scores, internal consistency, test-retest, and interrater types of reliability were determined. Eight participants with stroke and 20 neurologically intact participants were assessed twice. To inspect the discriminative power of the battery, 63 participants without brain impairment were tested with the Rus-BCoS. Additionally, the Russian version of the Montreal Cognitive Assessment (MoCA), Quantitative Assessment of Speech in Aphasia, and Luria's Neuropsychological Assessment Battery were used to examine convergent validity, sensitivity, and specificity of the Rus-BCoS. RESULTS: The internal consistency as well as test-retest and interrater reliability of the Rus-BCoS satisfied criteria for the research use. Performance on a majority of tasks in the battery correlated significantly with independently validated tests that putatively measure similar cognitive processes. Critically, all patients with aphasia returned nonzero scores in at least one task in all the Rus-BCoS sections, with the exception of the Controlled Attention section where two patients with severe executive control deficits could not perform. CONCLUSIONS: The Rus-BCoS shows promise as a comprehensive cognitive screening tool that can be used by clinicians working with Russian-speaking persons experiencing poststroke aphasia after much further validation and development of reliable normative standards. Given a lack of quantitative neuropsychological assessment tools in Russia, however, we contend the Rus-BCoS offers potential benefits to clinicians and patients. However, data from research studies with a broader sample of Russian speakers are needed.

[RESULTS OF DUST FACTOR IN COPPER PYROMETALLURGY].

The dust entering the air of the working zone of metallurgical shops was shown to be presented by a disintegration aerosols originating in crushing and transporting ore materials and condensation occurring in the course of smelting, converting and fire-refining copper. The overwhelming majority of the grains have a size of 2.1-5.0 mm, which determines a fixed condition of the presence of given dust in the working area, its long presence in the deeper parts of the respiratory system. At the preparatory stages in the composition of the dust there are presented significant amounts of crystalline silicon dioxide possessing of the fibrogenic impact on the body. In the dust the presence of the crystalline silicon dioxide, arsenic, nickel, cadmium determines its carcinogenic hazard. The elevated dustiness of the air is noted with the reflective and especially mine melting, due to the imperfection of the technological equipment and sanitary technical devices. Autogenous smelting processes have demonstrated their hygienic advantage over outdated methods of producing blister copper mining and smelting reflectivity.

Caries experience and treatment response among groups of Finnish, German and Russian children. A retrospective study between 1995 and 1989.

AIM: This study was designed to describe caries experience and treatment response in groups of children in three countries--Finland, Germany and Russia--with different systems of public dental care. MATERIALS AND METHODS: Information concerning permanent teeth (carious and filled surfaces, type of restorative treatment and applied sealants) was collected retrospectively from existing dental records of 12-year-old children who had been treated in dental practices over six years, retrospectively between 1995 and 1989. Prior to conducting the study, research meetings were held among all participating personnel to standardise data collection and terminology as much as possible. STATISTICS: The analysis of variance (ANOVA) was used to test the difference between the means of the various types of data derived from the three countries. RESULTS: Sealants were most commonly used in Finland at a rate of 5.0/child and 3.3 in Germany, but only for a few children in Russia (0.1). Caries increments (cumulative figure of primary and secondary caries surfaces over the six follow-up years of the study) differed very much between these countries. It was very high in Russia (7.4) and in Germany (5.3), but low in Finland (1.6). All the caries surfaces were filled in Finland and in Germany; in Russia, the cumulated number of filled surfaces was smaller than the respective number of caries surfaces (6.4/7.4). The most commonly used restorative filling material was amalgam in Germany and in Russia, but composite or glass ionomer cements in Finland. CONCLUSION: The cost effectiveness of sealant application programs should be considered as exemplified by the Finnish dental care system. The data showed a need for preventive programs in Germany, and this has actually been emphasised since 1993. In Russia, there is an urgent need to implement preventive programs for 6-year-old children and also to provide the necessary restorative treatment.

Two and a half-year outcome of caries-preventive programs offered to groups of children in the Solntsevsky district of Moscow.

This study examined the 2.5-year outcome of preventive programs - based on the Nexö method - offered to three groups of children from Solntsevsky, a district of Moscow. Study group A consisted of 45 3-year-olds, study group B of 50 6-year-olds, and study group C of 50 11-year-olds. A similar number of children were selected as control groups and they followed the normal dental service provided by the local Health Service System in the district. The caries-preventive programs offered to the study groups were based on: (1) education of the child, parents and teachers in the caries disease, (2) training in toothbrushing. In addition, the children in study groups B and C were offered professional plaque removal, applications of sodium fluoride (2%) and sealant applications according to individual needs. The children in groups B and C were clinically examined in March 1994 (baseline) after 1 and 2.5 years, respectively. Because of the age of the children in group A, these children were only examined once, after the study had been completed. After 2.5 years the children in all three study groups had improved their oral health status significantly compared to the children in the control group. The caries experience among the children in study group A was about half of that observed among children in the control group (4.91 def-s versus 8.60 def-s). The program was highly effective in controlling dental caries in the permanent dentition among the children in the study groups, who finished with a mean DMF-S of 0.28 (group B) and 3.12 (group C) compared to 2.24 and 6.35 among the children in the corresponding control groups. Nearly all the children used fluoridated toothpaste. The mean number of visits to the clinic decreased from year 1 to year 2 (5 versus 3.4 in study group B and 4.5 versus 3.3 in study group C). In conclusion, the preventive programs were highly effective with regard to improving the level of oral hygiene, and thereby reducing or even controlling the plaque-induced disease activity.

Background factors affecting dental caries in permanent teeth of Finnish and Soviet children.

The aim of this study was to analyze the association between some general background factors and caries experience in two groups of Finnish children (from Helsinki and Kuopio) and Soviet children (Moscow and Leningrad). A total of 1187 schoolchildren, ages seven, nine and twelve years, were examined and information about their health habits was gathered by questionnaire. Questions included use of sweets, cakes, soft drinks, sugar-sweetened coffee and tea, toothbrushing frequency and mother's education. Except for age, the factors that explain caries experience clearly differ in Finnish and Soviet children.

Surface-specific effect of a mineralizing agent on the permanent teeth and on periodontal status.

In a two-year clinical trial the surface-specific effect of a mineralizing agent on selected permanent teeth was evaluated as well as the effect of this agent on periodontal health in children. Compared with positive controls (Control group, n = 123, biweekly mouthrinsing with placebo and 0.2% NaF solutions), among children in the test group (n = 123, biweekly mouthrinsing with 2% Remodent and 0.2% NaF solutions) the mineralizing agent clearly affected periodontal health (as determined by the prevalence of subjects with gingival bleeding and occurrence of affected sextants at risk) positively, in addition to having a positive effect on the incidence of EFD lesions. The mineralizing agent tested was not found to have adverse effects (as determined by the prevalence of subjects with dental calculus and occurrence of affected sextants at risk). Use of the mineralizing agent is recommended especially during posteruptive maturation of permanent teeth.

Effect of the mineralizing agent on the permanent teeth.

In a two-year pragmatic clinical trial, the effect of the mineralizing agent was evaluated on permanent teeth of the first eruption group among Finnish children (7-years old at the beginning of the study) with a low prevalence of DFS. In the test group (n = 123, biweekly mouthrinsing with a 2% solution of mineralizing agent and 0.2% NaF solution) the percentage reduction in increment of both EFDS and DFS was high, whereas in the control group (n = 123, biweekly mouthrinsing with placebo and 0.2% NaF solutions) the incidence for symptoms of caries disease did not differ from that normally found in this age cohort. Positive clinical effect of tested solution was age-related and was associated with remineralization of old and inhibition of occurrence of new EFD lesions.

Dietary selenium protects against acute toxicity of T-2 toxin in rats.

The efficacy of dietary selenium (Se) supplementation on acute toxicity of T-2 toxin was investigated. Wistar male rats were divided into six groups with 15 rats in each and fed for 6 weeks ad libitum a semi-synthetic diet containing either 0.03 (groups 1 and 2), 0.5 (groups 3 and 4) or 2.5 mg Se/kg (groups 5 and 6). By the end of the experiment the rats in groups 2, 4 and 6 were administered once per os 3.8 mg/kg body weight T-2 toxin, while the animals in groups 1, 3 and 5 received equal doses of the solvent. Twenty-four hours after administration of the toxin the surviving rats were sacrificed and the liver microsomes isolated and determined for activities of enzymes relating to xenobiotics metabolism and Se. The results showed that feeding the rats 2.5 mg Se/kg diet increased the deethylation rate of 7-ethoxycoumarin by 42% and slightly decreased (20%) glutathione-S-transferase activity. Twenty-four hours after the administration of T-2 toxin the lethality percentages in groups 2, 4 and 6 were 47%, 27% and 20%, respectively. Furthermore, administration of T-2 toxin to group 6 rats resulted in a significant decrease in the level of cytochrome P-450 and 7-ethoxycoumarin deethylase activity (to 78% and 51%, respectively) compared to the control group. At the same time a 72% increase in the UDP-glucuronosyltransferase activity and of 61% in epoxide hydrolase activity compared to the control group was found. Similarly, although somewhat smaller, changes were seen in the group 4 rats receiving 0.5 mg Se/kg diet.(ABSTRACT TRUNCATED AT 250 WORDS)

The effect of aspartame on the activity of rat liver xenobiotic-metabolizing enzymes.

Male, Wistar rats were administered aspartame (40 or 4000 mg/kg body weight) in their diet for 90 days. By 45 days, the activities of three microsomal enzymes, epoxide hydrolase, carboxylesterase, and p-nitrophenyl-UDP-glucuronosyltransferase, were significantly increased in rats consuming 4000 mg/kg of aspartame. By 90 days, however, the activity of the xenobiotic-metabolizing enzymes of the rats given aspartame did not differ significantly from the activity of control animals. From these results, we conclude that the consumption of aspartame does not substantially alter the function of the hepatic microsomal enzymes which protect the organism from foreign compounds found in its environment and food.

Mineralizing agents in caries prevention: a review of the effects of Remodent.

Caries reduction from tooth brushing with Remodent occurs according to age, from 37.8% to 83.7% during a two to three year follow-up. The highest reduction was gained when the program was started at the age of 2. When Remodent-solution and -varnish were tested in one to three year follow-up, reductions in caries occurred from 20% to 91%. These studies also showed that the effect was best when the preventive treatment was started early.