The Oral Mucosa Status and the Correlation between the Functional Parameters and the Level of Nitric Oxide Metabolites in Saliva among Patients with GERD.

The study involved 91 patients (48 women and 43 men), aged from 18 to 70 years with GERD. All patients underwent the clinical dental examination according to a single scheme including general clinical manifestations (nausea, single vomiting, belching, heartburn, pain in the epigastrium and around the navel, and poor appetite) and dental manifestations of GERD. The objective assessment of the dental status of the examined patients included the measurement of the functional parameters of the mixed saliva, buffer capacity (BC) of saliva, and the detection of the nitric oxide metabolites (NOx) content in saliva from the right parotid salivary gland ("SRPSG") and in blood serum using the indirect method based on the determination of the stable metabolites: nitrates and nitrites using the Griess reaction. It was established that salivation rate among patients with GERD with the prevailing of ACR and SACR was at the lower limit of normal values (0.32 + 0.19 ml/min), and the salivation rate among patients with the prevailing of SALCR was low (0.10 + 0.04 ml/min). The BC of saliva among patients with the prevailing of ACR and SACR was high (9.07 + 1.23 mmol eq/l and 9.40 + 1.71 mmol eq/l, respectively) and was reduced among patients with the prevailing of SALCR (7.63 + 0.18 mmol eq/l). The NOx level in SRPSG among patients with GERD was increased (especially in Group 3 (20.93 + 11.23 umol/l)). The direct correlation between the indicators of sialometry, the level of the BC of saliva, and the NOx level in SRPSG were established during the study.

[Consensus resolution on a modern view on the therapeutic and prophylactic effect of individual oral care products containing fluoride]. / Rezoliutsiia Ékspertnogo soveta 'Sovremennyi vzgliad na lechebno-profilakticheskoe deistvie individual'nykh sredstv dlia ukhoda za polost'iu rta, soderzhashchikh ftoridy'.

The purpose of the publication was to present the materials of the Expert Council Consensus on 'A Modern View on the Treatment and Preventive Effect of Fluoride Containing Personal Oral Care Products', which took place on April 21, 2019 in Moscow (Russia) with the support of the pharmaceutical company JSC GlaskoSmitKlein Helsker. During the work of the expert council, a solution was developed for the safe use of fluoride-containing oral hygiene products as part of fluoride prevention of dental caries. In the real conditions of everyday life, it is advisable for dentists to: use local fluoride-containing agents to know the concentration of fluoride in drinking water and in areas with low and optimal levels of it; recommend fluorides for daily use in small concentrations, for example, for children from 2 years of age to brush their teeth twice a day with fluoride toothpaste for at least 3 minutes; children up to 6 years old, when brushing their teeth once, use no more than a pea-size piece of toothpaste with 500 ppm of fluoride; toothpastes with fluoride concentration from 500 to 5000 ppm should be admitted depending on the risk level of caries development; rinses with a fluoride concentration of 0.025-0.05% should be recommended for children from 6 years and adults twice a day for 1 minute after brushing teeth; for patients with a high risk of caries, periodically (from 2 to 6 times a year) to carry out applications with agents with high concentration of fluorides; for prolonging the effect of local fluorine-containing agents advise patients to refrain from eating and drinking for an hour after their use. Dentists should know the methods of fluoride use in dentistry, since fluoride prevention of caries should be an integral part of their therapeutic and preventive work.

Surface-specific effect of a mineralizing agent on the permanent teeth and on periodontal status.

In a two-year clinical trial the surface-specific effect of a mineralizing agent on selected permanent teeth was evaluated as well as the effect of this agent on periodontal health in children. Compared with positive controls (Control group, n = 123, biweekly mouthrinsing with placebo and 0.2% NaF solutions), among children in the test group (n = 123, biweekly mouthrinsing with 2% Remodent and 0.2% NaF solutions) the mineralizing agent clearly affected periodontal health (as determined by the prevalence of subjects with gingival bleeding and occurrence of affected sextants at risk) positively, in addition to having a positive effect on the incidence of EFD lesions. The mineralizing agent tested was not found to have adverse effects (as determined by the prevalence of subjects with dental calculus and occurrence of affected sextants at risk). Use of the mineralizing agent is recommended especially during posteruptive maturation of permanent teeth.

Effect of the mineralizing agent on the permanent teeth.

In a two-year pragmatic clinical trial, the effect of the mineralizing agent was evaluated on permanent teeth of the first eruption group among Finnish children (7-years old at the beginning of the study) with a low prevalence of DFS. In the test group (n = 123, biweekly mouthrinsing with a 2% solution of mineralizing agent and 0.2% NaF solution) the percentage reduction in increment of both EFDS and DFS was high, whereas in the control group (n = 123, biweekly mouthrinsing with placebo and 0.2% NaF solutions) the incidence for symptoms of caries disease did not differ from that normally found in this age cohort. Positive clinical effect of tested solution was age-related and was associated with remineralization of old and inhibition of occurrence of new EFD lesions.

Mineralizing agents in caries prevention: a review of the effects of Remodent.

Caries reduction from tooth brushing with Remodent occurs according to age, from 37.8% to 83.7% during a two to three year follow-up. The highest reduction was gained when the program was started at the age of 2. When Remodent-solution and -varnish were tested in one to three year follow-up, reductions in caries occurred from 20% to 91%. These studies also showed that the effect was best when the preventive treatment was started early.