RESUMO
The effects of multiwalled carbon nanotubes on epitheliocytes of different compartments of the gastrointestinal tract and urothelium of different compartments of the renal nephron were studied in CBA mice. The nanotubes affected mouse gastrointestinal mucosa and renal urothelium. The cell reaction in the macula densa of the renal distal tubules and the immune system reaction to oral nanotubes were detected. A possible effect of nanotubes administered orally on the renal filtration function was hypothesized.
Assuntos
Portadores de Fármacos/toxicidade , Mucosa Intestinal/efeitos dos fármacos , Nanotubos de Carbono/toxicidade , Administração Oral , Animais , Portadores de Fármacos/metabolismo , Trato Gastrointestinal/citologia , Trato Gastrointestinal/efeitos dos fármacos , Absorção Intestinal , Túbulos Renais Distais/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos CBA , Urotélio/efeitos dos fármacosRESUMO
The demographic analysis of population-age mortality from malignant neoplasms of the population of RF in the years 1980-2008 enables to see the real presentation of the positive impact of medicine and the negative impact of the environment, but also to reveal fundamental biological processes that determine the health and life expectancy of Russian men and women. The authors allocate the leading role in the origin and development of malignant tumors for the aging process.
Assuntos
Envelhecimento , Neoplasias/etiologia , Neoplasias/mortalidade , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Pré-Escolar , Interpretação Estatística de Dados , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Mortalidade/tendências , Federação Russa/epidemiologia , Fatores Sexuais , Adulto JovemRESUMO
In this work kinetic analysis of the age-specific death rate of the population of the Russian Federation was made. We performed the verifying of the hypotheses about growth of the aging rate of the population of the Russian Federation. The verification displayed that at the time period under review the aging rate of the population of the Russian Federation had not changed, and the growth of the death rate in 90th years of the XX century associates with worsening of the living conditions.
Assuntos
Envelhecimento , Bases de Dados Factuais , Avaliação Geriátrica/estatística & dados numéricos , Mortalidade/tendências , Dinâmica Populacional , Distribuição por Idade , Idoso , Interpretação Estatística de Dados , Feminino , Humanos , Cinética , Masculino , Federação Russa/epidemiologiaAssuntos
Hidroxilisina/análogos & derivados , Criança , Pré-Escolar , Humanos , Hidroxilisina/urina , MétodosRESUMO
The composition of the intracellular lipids was studied in four strains of Ustilago zeae differing as regards their hybridization type. In all strains, irrespective of the hybridization type, the bulk of the lipids are formed during the first three days of growth and constitute 43.2--55.7% of the weight of the dry cells. It was established that the total lipid fraction is composed of: phospholipids + monoglycerides, sterols, free fatty acids, diglycerides and sterol esters. The qualitative composition of the total lipids was found to be identical in all four strains regardless of the time of incubation of the cultures. While the qualitative composition remains constant, the ratio of the individual fractions changes in the various strains during the process of incubation. However, compatible strains with respect to hybridization do not differ as regards the amount of individual lipid fractions, while strains incompatible with respect to hybridization differ as regards this trait.
