[Primary involvement of the dura mater spinalis in Hodgkin's lymphoma].

The paper describes a case of Hodgkin's lymphoma at a very rare site (primary, solitary involvement of the dura mater spinalis) with its immunohistochemically verified diagnosis in a 38-year-old man.

[Role of a transforming growth factor beta-1 in regulation of invasive growth of prostatic adenocarcinoma]. / Rol' transformiruiushchego faktora rosta beta 1 v reguliatsii invazivnogo rosta adenocartsinomy predstal'noi zhelezy.

Immunohistochemical study of histological sections and immunochemical study in supernatants of primary cultures demonstrated a marked increase of the factor production in the regions of the background changes outside foci of carcinoma invasive growth. There was no difference in the type of expression of TGFbeta-I and TGFbeta-II receptors in morphologically different regions of the tumour. TGFbeta-I is considered as a principal factor that mediates hyperplastic reaction of the stroma in prostatic adenocarcinoma outside the zones of invasive growth. Formation of reactive stroma, in the authors' opinion, plays the role of a defensive mechanism hindering invasion of tumour cells into the connective tissue and its progression.

[Blood vessels in different systems of limb traction (experimental study)]. / Krovenosnye sosudy pri raznykh rezhimakh distraktsii konechnosti (éksperimental'noe issledovanie).

In the experiments performed in 108 dogs, structure of the vascular bed, elongated by means of Ilizarov's apparatus in the extremity pelvic segment, has been studied, as well as the hemostatic system under various regimens of distraction. Under a spare regimen reorientation of the microcirculatory bed links and its neural apparatus according to the lines of tension and distension forces are revealed, as well as new formation and growth of capillaries, nerve fibers and terminals. In the vessels of the muscular type, at the level of the osseous regenerate, the following changes are described: distractive rearrangement and intercalated growth (such as activation of biosynthetic processes in endothelium, adventitium and smooth muscle (SMC) cells), intensive proliferation and longitudinal reorientation of the activated SMC in the middle tunic, in the larger arteries a powerful longitudinal muscular layer is formed between the endothelium and the internal elastic membrane. The tendency for hypercoagulation, that exists at that time, is compensated by antithrombogenic and fibrinolitic blood activity. Under an elevated rate of the distraction or under an unstable fixation of the bone fragments in the apparatus, hypercoagulation is not compensated till the end of the experiment, and in the vessels, simultaneously with the distractive rearrangement, thrombosis, recalibration and obliteration are observed. The data observed and those of the literature, demonstrate that vascular adaptation to a dosed distraction is performed by means of certain rearrangements in the walls and of intercalated growth influenced by the effect of the distension forces. These phenomenon make the base of the mechanisms developing in the organism during its evolution and ontogenesis.