The Relationship of Knowledge of Osteoporosis and Bone Health in Postmenopausal Women in Silesia Osteo Active Study.

The Silesia Osteo Active Study was designed to assess osteoporosis-related knowledge and its relationships with skeletal status in an epidemiological population-based program. Participants were chosen randomly from postmenopausal women over 55 yr. The study group consisted of 388 patients (mean age 65 ± 7). All participants fulfilled medical and socioeconomic questionnaires and test concerning osteoporosis-related knowledge. They underwent proximal femur and lumbar spine densitometry. The mean level of osteoporosis knowledge was 7.3 ± 2.0 for 10 questions. Osteoporosis knowledge seems to have no influence on densitometry results in the population; nevertheless it improves femoral neck (FN) density in those without prior personal experience of osteoporosis (r = 0.15; p < 0.05). Higher knowledge of osteoporosis was connected with osteoporosis in family, hormone replacement therapy or smoking history, and higher educational degree. The level of knowledge was significantly better in younger than in older participants (7.4 vs 6.7; p < 0.01). Osteoporosis (T-score < -2.5) was established in 6.4%, 2%, and 33% for FN, total hip, and spine, respectively. As a conclusion, current study revealed a positive influence of the knowledge of osteoporosis on FN density in postmenopausal women without prior personal experience of the disease.

Quantitative ultrasound measurements in diabetic and nondiabetic patients with end-stage renal disease.

The aim of the study was to assess skeletal status in diabetic and nondiabetic subjects with end-stage renal disease (ESRD). One hundred twenty-three patients with ESRD (57 patients with diabetes: 9 type 1 and 48 type 2) and 66 nondiabetic patients were evaluated. Control group comprised 1541 subjects (614 males and 927 females). Diabetes and/or renal insufficiency was the only reason of bone disease and, in control group, no factors known to influence bone metabolism (chronic diseases or prolonged medications) were noted. Skeletal status was evaluated by quantitative ultrasound measurements at the hand phalanges using DBM 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s]). Because of some differences in mean age in subgroups of patients and controls, comparisons were performed using values of Z-score. In all diabetic patients, Z-score was significantly higher compared with nondiabetics (p < 0.05). In all type 1 diabetes patients, Z-score was significantly lower than in all nondiabetic patients (p < 0.05) and in patients with type 2 diabetes (p < 0.001). Z-score was also significantly lower in type 2 diabetics than in nondiabetic females (p < 0.00001) but did not differ in males. Comparisons between Z-scores in controls and patients showed that Z-score in nondiabetic females was significantly lower than in female controls (p < 0.000001), and in nondiabetic males--diabetic type 2 males as well as females--Z-score did not differ vs. results in adequate control group. Z-score was significantly lower in patients with diabetes type 1 vs. all controls (p < 0.001). Correlation analysis showed in all nondiabetic patients that Z-score was negatively affected by duration time of dialysis (r = -0.37, p < 0.01) and parathyroid hormone (PTH) serum level (r = -0.35, p < 0.01). In patients with type 1 diabetes, only PTH influenced significantly Z-score (r = -0.76, p < 0.05) and, in patients with type 2 diabetes, no significant correlations were obtained. Subjects with type 1 diabetes seemed to be sensitive for skeletal disturbances in a course of renal insufficiency, whereas subjects with type 2 diabetes did not show such skeletal pathology as shown by ultrasound measurements at hand phalanges.

[The influence of salmon calcitonin on changes in thyroid hormone concentration and on TSH secretion. I]. / Wplyw kalcytoniny lososiowej na zmiany stezen hormonów tarczycy i na wydzielanie TSH. Czesc I.

The aim of this investigation was determination of salmon calcitonin (sCT) influence on changes of thyroid hormones levels in serum. The investigation was carried out on a group of 26 patients. The group was divided in two different ways: into people younger and older than 65 years, and into men and women. Investigation protocol consists of 4 days. On the 1st day patients received 100U of SC, on the 2nd day--100U of SC and 0.4 mg TRH, on the 3rd day--0.4 mg TRH, on the 4th day--0.9% solution of NaCl and 5% solution of human albumin. T3, T4 fT3 and fT4 concentrations in serum were determined by RIA method.

[Influence of salmon calcitonin on changes in thyroid hormone concentration and on TSH secretion. II]. / Wplyw kalcytoniny lososiowej na zmiany stezen hormonów tarczycy i na wydzielanie TSH. Czesc II.

The aim of this investigation was determination of salmon calcitonin (SC) administration influence on hypothalamus-pituitary-thyroid axis. The investigation was carried out on a group of 26 patients. The group was divided in two different ways: into people younger and older than 65 years, and into men and women. Investigation protocol consists of 4 days. On the 1st day patients received 100U of SC, on the 2nd day--100U of SC and 0.4 mg TRH, on the 3rd day--0.4 mg TRH, on the 4th day--0.9% solution of NaCl and 5% solution of human albumin. TSH serum concentrations were determined by RIA method. Infusion of SC caused TSH serum concentration increase in all groups. This effect is qualitatively similar but quantitatively different in investigated groups. Administration of SC with TRH causes significantly smaller growth of TSH concentration than observed after infusion of TRH alone. The mechanism of SC influence on pituitary may be similar to the one of TRH.

[Activity of superoxide dismutase in erythrocytes and leukocytes and levels of zinc and copper in blood of patients with diabetes. Effect of diabetic treatment on examined parameters]. / Aktywnosc dysmutazy ponadtlenkowej w erytrocytach i leukocytach oraz stezenie cynku i miedzi we krwi u chorych na cukrzyce. Wplyw stosowanego leczenia przeciwcukrzycowego na badane parametry.

UNLABELLED: The purpose of the present work was to assess the relationship of leukocyte and erythrocyte superoxide dismutase activity to its cofactors concentrations i.e. zinc and copper in plasma and erythrocyte in diabetic patients and treatment variability. 104 patients were included in the study. 23 persons were in the control group. All patients were divided into 2 groups (NIDDM and IDDM). Patients with NIDDM were divided into 3 subgroups depending on treatment (insulin, gliclazide, dietary treated). In all groups, there were assessed following parameters: the leucocyte and erythrocyte SOD activity according to the method of Misra and Fridovich, and zinc and copper concentrations in plasma and erythrocyte, which were measured by flame absorption spectrophotometry. Statistical analysis was performed using the CRISP program. CONCLUSION: 1. The leukocyte and erythrocyte superoxide dismutase activity is significantly lowered in diabetes mellitus. 2. In diabetic patients both in type I and type II as in the healthy people, there is a close correlation between SOD activity and its cofactors i.e. zinc and copper erythrocyte concentrations. 3. Insulin and gliclazide treatment increases SOD activity and delays late diabetic complications.

[Various parameters of lipid metabolism after intra-arterial injections of ozone in patients with ischemia of the lower extremities and diabetes mellitus]. / Niektóre parametry gospodarki lipidowej po dotetniczych wstrzyknieciach ozonu u chorych na chorobe niedo-krwienna konczyn dolnych oraz cukrzyce.

In 50 subjects with arteriosclerotic ischaemia of the lower extremities and 41 subjects with diabetes mellitus ozone was applied intra-arterially. Before and after the treatment serum lipids concentration was examined. In the group with arteriosclerotic ischemia significant decrease in cholesterol level and both his fractions was seen. Whereas in the group with diabetes the cholesterol LDL was significantly reduced. In both groups total lipids level serum was decreased. It suggests that ++ozone therapy set back the arteriosclerosis progress, normalized some parameters of lipid metabolism and improved HDL to LDL cholesterol fractions relationship.