Flexed femoral component improves kinematics and biomechanical effect in posterior stabilized total knee arthroplasty.

PURPOSE: The kinematics and biomechanics of the knee joint are important in ensuring patient satisfaction and functional ability after total knee arthroplasty (TKA). There has been no study on knee joint mechanics with regard to the sagittal alignment of the femoral component. The objective of this study is to determine the extent of the impact of the femoral component's sagittal alignment on kinematics and biomechanics. METHODS: A validated computational TKA model was used. The femoral component was simulated at - 3°, 0°, 5°, and 7° of flexion in the sagittal plane. This study evaluated the tibiofemoral (TF) joint kinematics, contact point, quadriceps force, and contact stress on the patellofemoral (PF) joint under a deep-knee-bend condition. RESULTS: The kinematics of the TF joint in the posterior direction increased with the flexion of the femoral component position. For all tasks, the overall posterior locations of the TF contact points were observed in the medial and lateral compartments as the femoral component flexion angle increased. The quadriceps force and contact stress on the PF joint decreased with the femoral component flexion. CONCLUSION: This study found that the femoral component sagittal position is an important factor in knee joint mechanics. In this study, the flexion of femoral component showed a stable reconstruction of the knee extensors' mechanism. Surgeons may consider neutral-to-mild flexed femoral component position, without concerns of anterior notching of the femoral cortex.

Tibiofemoral conformity variation offers changed kinematics and wear performance of customized posterior-stabilized total knee arthroplasty.

PURPOSE: Posterior-stabilized (PS)-total knee arthroplasty (TKA) can be applied in any of several variations in terms of the tibiofemoral conformity and post-cam mechanism. However, previous studies have not evaluated the effect of the condylar surface radii (tibiofemoral conformity) on wear in a customized PS-TKA. The present study involved evaluating the wear performance with respect to three different conformities of the tibiofemoral articular surface in a customized PS-TKA by means of a computational simulation. METHODS: An adaptive computational simulation method was developed that conduct wear simulation for tibial insert to predict kinematics, weight loss due to wear, and wear contours to results. Wear predictions using computational simulation were performed for 5 million gait cycles with force-controlled inputs. Customized PS-TKA designs were developed and categorized as conventional conformity (CPS-TKA), medial pivot conformity (MPS-TKA), and anatomical conformity (APS-TKA). The post-cam design in the customized PS-TKA is identical. We compared the kinematics, contact mechanics, and wear performance. RESULTS: The findings revealed that APS-TKA exhibited the highest internal tibial rotation relative to other TKA designs. Additionally, the higher contact area led to there being less contact stress although it did not directly affect the wear performance. Specifically, MPS-TKA exhibited the lowest volumetric wear. CONCLUSIONS: The results of the present study showed that tibiofemoral articular surface conformity should be considered carefully in customized PS-TKA design. Different wear performances were observed with respect to different tibiofemoral conformities. Even though APS-TKA exhibited an inferior wear performance compared to MPS-TKA, it proved to be better in terms of kinematics so its functionality may be improved through the optimization of the tibiofemoral articular surface conformity. Additionally, it should be carefully designed since any changes may affect the post-cam mechanism.

Comparison of the biomechanical effect of posterior condylar offset and kinematics between posterior cruciate-retaining and posterior-stabilized total knee arthroplasty.

BACKGROUND: The effect of the changes in the femoral posterior condylar offset (PCO) on anterior-posterior (AP) translation and internal-external (IE) rotation in cruciate-retaining (CR) and posterior-stabilized (PS) total knee arthroplasty (TKA) remains unknown. The purpose of this study was to compare the kinematics in CR and PS TKA with respect to the difference in prosthetic design and PCO change through a computational simulation. METHODS: We developed three-dimensional finite element models with the different PCOs of ±1, ±2 and ±3 mm in the posterior direction using CR and PS TKA. We performed the simulation with different PCOs under a deep knee bend condition and evaluated the kinematics for the AP and IE in CR and PS TKA. RESULTS: The more tibiofemoral (TF) translation in the posterior direction was found as PCO translated in posterior direction for both CR and PS TKA compared to the neutral position. However, the change of the AP translation with respect to the PCO change in CR TKA was greater than PS TKA. The more TF external rotation was found as PCO translated in the anterior direction for both CR and PS TKA compared to the neutral position. However, unlike the TF translation, the TF rotation was not influenced by the PCO change in both CR and PS TKA. CONCLUSION: The PCO magnitude was influenced by a postoperative change in the kinematics in CR TKA although a relatively smaller effect was observed in PS TKA. Hence, surgeons should be aware of the PCO change, especially for CR TKA.

Preservation of femoral and tibial coronal alignment to improve biomechanical effects of medial unicompartment knee arthroplasty: Computational study.

BACKGROUND: Medial unicompartmental knee arthroplasty (UKA) could be concerned with wear of the cartilage or the wear in the polyethylene (PE) insert. Mechanical alignment determines the biomechanical effect in the long term. However, previous computational studies all found that femoral and tibial components alignment in the UKA were rare, and the results varied. OBJECTIVE: The purpose of this study was to evaluate the biomechanical effect of the femoral and tibial component coronal alignment in varus and valgus conditions through computational simulation. METHODS: A three-dimensional finite element model of the intact knee was constructed from medical image data of one healthy subject. A medial UKA model of neutral position and various coronal components was developed from the intact knee joint model. The tibial varus-femoral valgus and tibial valgus-femoral varus conditions were analyzed with parallel component angles of 3°, 6° and 9° by using validated finite element models. We considered the contact stresses in the PE inserts and articular cartilage and the force on collateral ligament under gait cycle condition. RESULTS: Compared to the contact stress in the neutral position model, the contact stress on the PE insert increased in both tibial varus-femoral valgus and tibial valgus-femoral varus models. These trends were also observed in the case of the articular cartilage in remain compartment. However, the contact stress on the PE insert and articular cartilage increased largely in the tibial valgus-femoral varus model than in the tibial varus-femoral valgus model. The forces on the medial and lateral collateral ligaments increased in the tibial valgus-femoral varus model, whereas in the tibial varus-femoral valgus model, the forces decreased compared to the forces in the neutral position. The force on the anterior lateral ligament and popliteofibular ligament increased in the tibial varus-femoral valgus model as compared to the neutral position. CONCLUSIONS: Our study suggests that neutral alignment or less than 3° tibial varus-femoral valgus alignment in the coronal plane can be recommended in medial UKA to reduce the postoperative complications and to enhance the life expectancy of implants.

Patient-specific design for articular surface conformity to preserve normal knee mechanics in posterior stabilized total knee arthroplasty.

BACKGROUND: Contemporary total knee arthroplasty (TKA) provides remarkable clinical benefits. However, the normal function of the knee is not fully restored. Recent improvements in imaging and manufacturing have utilized the development of customized design to fit the unique shape of individual patients. OBJECTIVE: The purpose of the present study is to investigate the preservation of normal knee biomechanics by using specific articular surface conformity in customized posterior stabilized (PS)-TKA. METHODS: This includes customized PS-TKA, PS-TKA with conforming conformity (CPS-TKA), medial pivot conformity with PS-TKA (MPS-TKA), and PS-TKA with mimetic anatomy femoral and tibial articular surface (APS-TKA). In this study, kinematics, collateral ligament force and quadriceps force were evaluated using a computational simulation under a deep knee bend condition. RESULTS: A conventional TKA did not provide the normal internal tibial rotation with flexion leading to abnormal femoral rollback. The APS-TKA exhibited normal-like femoral rollback kinematics but did not exhibit normal internal tibial rotation. However, APS-TKA exhibited the most normal-like collateral ligament and quadriceps forces. CONCLUSIONS: Although the APS-TKA exhibited more normal-like biomechanics, it did not restore normal knee biomechanics owing to the absence of the cruciate ligament and post-cam mechanism.

Effect of Post-Cam Design for Normal Knee Joint Kinematic, Ligament, and Quadriceps Force in Patient-Specific Posterior-Stabilized Total Knee Arthroplasty by Using Finite Element Analysis.

The purpose of this study is to investigate post-cam design via finite element analysis to evaluate the most normal-like knee mechanics. We developed five different three-dimensional computational models of customized posterior-stabilized (PS) total knee arthroplasty (TKA) involving identical surfaces with the exception of the post-cam geometry. They include flat-and-flat, curve-and-curve (concave), curve-and-curve (concave and convex), helical, and asymmetrical post-cam designs. We compared the kinematics, collateral ligament force, and quadriceps force in the customized PS-TKA with five different post-cam designs and conventional PS-TKA to those of a normal knee under deep-knee-bend conditions. The results indicated that femoral rollback in curve-and-curve (concave) post-cam design exhibited the most normal-like knee kinematics, although the internal rotation was the closest to that of a normal knee in the helical post-cam design. The curve-and-curve (concave) post-cam design showed a femoral rollback of 4.4 mm less than the normal knee, and the helical post-cam design showed an internal rotation of 5.6° less than the normal knee. Lateral collateral ligament and quadriceps forces in curve-and-curve (concave) post-cam design, and medial collateral ligament forces in helical post-cam design were the closest to that of a normal knee. The curve-and-curve (concave) post-cam design showed 20% greater lateral collateral ligament force than normal knee, and helical post-cam design showed medial collateral ligament force 14% greater than normal knee. The results revealed the variation in each design that provided the most normal-like biomechanical effect. The present biomechanical data are expected to provide useful information to improve post-cam design to restore normal-like knee mechanics in customized PS-TKA.

Effects of posterior condylar offset and posterior tibial slope on mobile-bearing total knee arthroplasty using computational simulation.

BACKGROUND: Postoperative changes of the femoral posterior condylar offset (PCO) and posterior tibial slope (PTS) affect the biomechanics of the knee joint after fixed-bearing total knee arthroplasty (TKA). However, the biomechanics of mobile-bearing is not well known. Therefore, the aim of this study was to investigate whether alterations to the PCO and PTS affect the biomechanics for mobile-bearing TKA. METHODS: We used a computational model for a knee joint that was validated using in vivo experiment data to evaluate the effects of the PCO and PTS on the tibiofemoral (TF) joint kinematics, patellofemoral (PF) contact stress, collateral ligament force and quadriceps force, for mobile-bearing TKA. The computational model was developed using ±1-, ±2- and ±3-mm PCO models in the posterior direction and -3°, 0°, +3°, and +6° PTS models based on each of the PCO models. RESULTS: The maximum PF contact stress, collateral ligament force and quadriceps force decreased as the PTS increased. In addition, the maximum PF contact stress and quadriceps force decreased, and the collateral ligament force increased as PCO translated in the posterior direction. This trend is consistent with that observed in any PCO and PTS. CONCLUSIONS: Our findings show the various effects of postoperative alterations in the PCO and PTS on the biomechanical results of mobile-bearing TKA. Based on the computational simulation, we suggest that orthopaedic surgeons intraoperatively conserve the patient's own anatomical PCO and PTS in mobile-bearing TKA.

Comparison of Kinematics in Cruciate Retaining and Posterior Stabilized for Fixed and Rotating Platform Mobile-Bearing Total Knee Arthroplasty with respect to Different Posterior Tibial Slope.

Reconstructed posterior tibial slope (PTS) plays a significant role in kinematics restoration after total knee arthroplasty (TKA). However, the effect of increased and decreased PTS on prosthetic type and design has not yet been investigated. We used a finite element model, validated using in vitro data, to evaluate the effect of PTS on knee kinematics in cruciate-retaining (CR) and posterior-stabilized (PS) fixed TKA and rotating platform mobile-bearing TKA. Anterior-posterior tibial translation and internal-external tibial rotation were investigated for PTS ranging from -3° to 15°, with increments of 1°, for three different designs of TKA. Tibial posterior translation and external rotation increased as the PTS increased in both CR and PS TKAs. In addition, there was no remarkable difference in external rotation between CR and PS TKAs. However, for the mobile-bearing TKA, PTS had less effect on the kinematics. Based on our computational simulation, PTS is the critical factor that influences kinematics in TKA, especially in the CR TKA. Therefore, the surgeon should be careful in choosing the PTS in CR TKAs.

Multi-objective design optimization of high tibial osteotomy for improvement of biomechanical effect by using finite element analysis.

Medial opening wedge high tibial osteotomy (HTO) makes the proximal tibia a highly unstable structure and causes plates and screws to be the potential sources for mechanical failure. However, asymmetrical callus and incomplete bone formations underneath the plates (TomoFix) have been recent concerns in clinical and experimental studies related to HTO due to the high stiffness. The purpose of this study was to evaluate the biomechanical effect of the TomoFix plate system with respect to changes in design using a computational simulation. A parametric three-dimensional model of HTO was constructed from medical image data. The design parameters for the HTO plate were evaluated to investigate their influence on biomechanical effects, and the most significant factors were determined using Taguchi-style L27 orthogonal arrays. Multi-objective optimization was used to identify the wedge micromotion stability without the stress shielding effect that occurs in the bone plate. The initial design showed that the high stiffness of the plate caused stress shielding on the bone and plate. However, the optimal design led to sharing the stress and load with the bone plate to eliminate stress shielding. In addition, the stability required for the plate could be found in the micromotions of the wedge for the optimal design. The optimal condition of design parameters was successfully determined using the Taguchi and multi-objective optimization method, which was shown to eliminate stress shielding effects. The results showed that an optimal design demonstrated the feasibility of design optimization and improvements in biomechanical stability for HTO. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2956-2965, 2018.

Comparative Matched-Pair Analysis of Keyhole Bone-Plug Technique Versus Arthroscopic-Assisted Pullout Suture Technique for Lateral Meniscal Allograft Transplantation.

PURPOSE: To compare the clinical outcomes and meniscal extrusion measured by magnetic resonance imaging (MRI) between the keyhole bone-plug technique and arthroscopic-assisted pullout suture technique in lateral meniscal allograft transplantation (MAT). METHODS: Between October 2009 and February 2015, patients who underwent lateral MAT were retrospectively reviewed. The inclusion criteria were patients with symptomatic knees that had undergone total or subtotal meniscectomy who were treated with lateral MAT with a minimum follow-up period of 2 years. We excluded 13 patients with anterior cruciate ligament injury to the ipsilateral knee and 6 patients with combined cartilage procedures. In addition, we excluded 19 patients because they did not undergo follow-up MRI and 13 patients who did not undergo more than 2 years of follow-up. Thirty-seven patients who underwent lateral MAT with the keyhole bone-plug technique were identified and assigned to group A. Forty-five patients who underwent lateral MAT with the arthroscopic-assisted pullout suture technique (group B) were then matched by age, body mass index, and time from previous meniscectomy to lateral MAT. Clinical outcome assessments included preoperative and postoperative subjective International Knee Documentation Committee (IKDC), Tegner, and Lysholm scores and the visual analog scale (VAS) score for pain evaluation. MRI was used to assess meniscal extrusion. RESULTS: The mean follow-up period was 35.8 ± 6.5 months (range, 24-65 months) in group A and 34.6 ± 6.2 months (range, 24-55 months) in group B. Significant improvements in the VAS pain score, subjective IKDC score, Tegner score, and Lysholm score after lateral MAT were found (P < .001), and there were no significant differences between the 2 groups at final follow-up (VAS score, 1.4 ± 0.8 in group A and 1.2 ± 1.0 in group B [P = .164]; subjective IKDC score, 72.9 ± 8.1 in group A and 74.2 ± 7.3 in group B [P = .427]; Tegner activity score, 4.0 ± 0.9 in group A and 4.1 ± 0.8 in group B [P = .374]; and Lysholm score, 75.5 ± 10.6 in group A and 76.2 ± 11.8 in group B [P = .786]). On MRI, the meniscal extrusion extent was 3.1 ± 0.9 mm in group A and 2.9 ± 0.8 mm in group B (P = .223), and the relative percentages of extrusion were 27.0% ± 3.9% and 26.1% ± 4.2%, respectively (P = .273). CONCLUSIONS: Compared with the keyhole bone-plug technique, the arthroscopic-assisted pullout suture technique in lateral MAT showed comparable clinical and MRI results at short-term follow-up. LEVEL OF EVIDENCE: Level IV, case series with intragroup comparisons.

Effect of femoral component position on biomechanical outcomes of unicompartmental knee arthroplasty.

BACKGROUND: The positions of unicompartmental femoral components do not always follow the neutral center of the medial distal femoral condyle. The biomechanical effect of the center of the distal femoral condyle has not yet been evaluated, and the optimal femoral position in unicompartmental knee arthroplasty (UKA) is yet to be biomechanically justified. The purpose of this study was to evaluate, using finite element analysis, the effect of the center of the distal femoral component on the biomechanical outcomes of UKA with respect to the contact stresses in the polyethylene (PE) insert and articular cartilage. METHODS: Five models in which the centers of the distal femoral components were translated by three millimeters and five millimeters to the medial and lateral sides, respectively, from the neutral position were modeled and analyzed in a gait loading condition. RESULTS: The contact stresses on the PE insert increased as the center of the femoral component translated to the lateral side and, in contrast, the contact stresses decreased as it translated to the medial side. For the articular cartilage the contact stresses increased and decreased as the center of the femoral component translated to the medial and lateral sides. CONCLUSION: This study implied that the best position for the femoral component in UKA could be the center of the distal femoral condyle. Femoral component position could be one of the sensitive factors that influenced the contact stresses on the PE insert and articular cartilage, and the postoperative significance of the femoral component position in UKA.

The increase in posterior tibial slope provides a positive biomechanical effect in posterior-stabilized total knee arthroplasty.

PURPOSE: This study aims to clarify the influence of the posterior tibial slope (PTS) on knee joint biomechanics after posterior-stabilized (PS) total knee arthroplasty (TKA) using a computer simulation. METHODS: A validated TKA computational model was used to evaluate and quantify the effects of an increased PTS. In order to conduct a squat simulation, models with a - 3° to 15° PTS using increments of 3° were developed. Forces on the quadriceps and collateral ligament, a tibial posterior translation, contact point on a polyethylene (PE) insert, and contact stress on the patellofemoral (PF) joint and post in a PE insert were compared. RESULTS: The maximum force on the quadriceps and the PF contact stress decreased with increases in the PTS. The kinematics on the tibiofemoral (TF) joint translated in an increasingly posterior manner, and the medial and lateral contact points on a PE insert were located in posterior regions with increases in the PTS. Additionally, increases in the PTS decreased the force on the collateral ligament and increased the contact stress on the post in a PE insert. A higher force on the quadriceps is required when the PTS decreases with an equivalent flexion angle. CONCLUSIONS: A surgeon should be prudent in terms of determining the PTS because an excessive increase in the PTS may lead to the progressive loosening of the TF joint due to a reduction in collateral ligament tension and failure of the post in a PE insert. Thus, we support a more individualized approach of optimal PTS determination given the findings of the study.

Effect of joint line preservation on mobile-type bearing unicompartmental knee arthroplasty: finite element analysis.

In this study, we performed a virtual mobile-bearing unicompartmental knee arthroplasty (UKA) on the contact pressure in the tibial insert and articular cartilage by using finite element (FE) analysis to understand clinical observations and elaborate on the potential risks associated with a joint line preservation such as wear on tibial insert and osteoarthritis on other compartment. Neutral position of the knee joint was defined in 0 mm joint line, and contact pressure between tibial insert and articular cartilage varies with respect to changes of joint line. Therefore, evaluation of contact pressure may provide the degree of joint line preservation. The FE model for the joint line was developed using a perpendicular projection line from the medial tibial plateau to the anatomical axis. Seven FE models for joint lines in cases corresponding to ± 6, ± 4, ± 2, and 0 mm were modeled and analyzed in normal level walking conditions. The maximum contact pressure on the superior and inferior surfaces of the polyethylene insert increased when the joint line became positive while the maximum contact pressure on the articular cartilage increased when the joint line became negative. The increase in the maximum contact pressure in the positive joint line exceeded that in the negative joint line, and this lead to an unsymmetrical maximum contact pressure distribution with respect to the joint line from a 0 reference. The joint line elevation was sensitive to increases or decreases in maximum contact pressures in the mobile-bearing UKA. The findings of the study determined that postoperative joint line preservation is important in mobile-type bearing UKA.

Femoral component alignment in unicompartmental knee arthroplasty leads to biomechanical change in contact stress and collateral ligament force in knee joint.

BACKGROUND: In recent years, the popularity of unicompartmental knee arthroplasty (UKA) has increased. However, the effect of femoral component positioning in UKA continues to invite a considerable debate. The purpose of this study involved assessing the biomechanical effect of mal-alignment in femoral components in UKA under dynamic loading conditions using a computational simulation. METHODS: A validated finite element model was used to evaluate contact stresses in polyethylene (PE) inserts and lateral compartment and force on collateral ligament in the femoral component ranging from 9° of varus to 9° of valgus. RESULTS: The results indicated that contact stress on the PE insert increased with increases in the valgus femoral alignment when compared to the neutral position while contact stress on the lateral compartment increased with increases in the varus femoral alignment. The forces on medial and lateral collateral ligaments increased with increases in valgus femoral alignments when compared to the neutral position. However, there was no change in popliteofibular and anterior lateral ligaments with respect to the malpositioning of femoral component. CONCLUSION: The results of the study confirm the importance of conservation in post-operative accuracy of the femoral component since the valgus and varus femoral malalignments affect the collateral ligament and lateral compartment, respectively. Our results suggest that surgeons should avoid valgus malalignment in the femoral component and especially malalignment exceeding 9°, which may induce higher medial collateral ligament forces.

Influence of Increased Posterior Tibial Slope in Total Knee Arthroplasty on Knee Joint Biomechanics: A Computational Simulation Study.

BACKGROUND: The reconstructed posterior tibial slope (PTS) plays a significant role in restoring knee kinematics in cruciate-retaining-total knee arthroplasty (TKA). A few studies have reported the effect of the PTS on biomechanics. METHODS: This study investigates the effect of the PTS on tibiofemoral (TF) kinematics, patellofemoral (PF) contact stress, and forces at the quadriceps, posterior cruciate ligament (PCL) and collateral ligament after cruciate-retaining-TKA using computer simulations. The simulation for the validated TKA finite element model was performed under deep knee bend condition. All analyses were repeated from -3° to 15° PTS in increments of 3°. RESULTS: The kinematics on the TF joint translated increasingly posteriorly when the PTS increased. Medial and lateral contact points translated in posterior direction in extension and flexion as PTS increased. The maximum contact stress on the PF joint and quadriceps, and collateral ligament force decreased when the PTS increased. An implantation of the tibial plate with increased PTS reduced the PCL load. Physiologic insert movement led to an increasingly posterior position of the femur and reduced quadriceps force especially for knee flexion angles above high flexion (120°) when compared to TKA with a decreased slope of the tibial base plate. CONCLUSION: An increase in the PTS increased medial and lateral movements without paradoxical motion. However, an excessive PTS indicated progressive loosening of the TF joint gap due to a reduction in collateral ligament tension during flexion.

The Effect of Patient-Specific Instrumentation Incorporating an Extramedullary Tibial Guide on Operative Efficiency for Total Knee Arthroplasty.

This retrospective study was to determine if patient-specific instrumentation (PSI) for total knee arthroplasty (TKA) leads to shortened surgical time through increased operating room efficiency according to different tibial PSI designs. 166 patients underwent primary TKA and were categorized into three groups as follows: PSI without extramedullary (EM) tibial guide (group 1, n = 48), PSI with EM tibial guide (group 2, n = 68), and conventional instrumentation (CI) group (group 3, n = 50). Four factors were compared between groups, namely, operative room time, thickness of bone resection, tibial slope, and rotation of the component. The mean surgical time was significantly shorter in the PSI with EM tibial guide group (group 2, 63.9 ± 13.6 min) compared to the CI group (group 3, 82.8 ± 24.9 min) (P < 0.001). However, there was no significant difference in the PSI without EM tibial guide group (group 1, 75.3 ± 18.8 min). This study suggests that PSI incorporating an EM tibial guide may lead to high operative efficiency in TKA compared to CI. This trial is registered with KCT0002384.

Wear predictions for UHMWPE material with various surface properties used on the femoral component in total knee arthroplasty: a computational simulation study.

The wear of ultrahigh-molecular weight polyethylene (UHMWPE) tibial inserts in total knee arthroplasty (TKA) remains a major limitation that hinders the longevity of clinically successful devices. Surface properties significantly affect the overall performance of TKA, and surface modification with mechanically and chemically stable materials is an effective method for overcoming the wear of TKA. However, wear tests are not cost-efficient or time-efficient; thus, the effects of geometric, loading, and alignment perturbations are often evaluated via parametric studies. Computational wear prediction using a finite element (FE) model followed by validation through comparison with experimental data is effective for assessing new prosthetic designs or surface change methods prior to functional testing and surgical implementation. The aim of this study was to evaluate the weight loss, wear depth, and kinematics for different surface properties, including nanostructured diamond (NSD), diamond-like carbon (DLC), titanium-nitride (TiN), and oxidized zirconium (OxZr) on femoral components in TKA using FE analysis under gait-cycle loading conditions. Weight loss and wear depth were lowest with OxZr followed by TiN, NSD, and DLC. However, the DLC femoral component did not show any improvement in wear rate compared to an uncoated cobalt-chromium (Co-Cr) femoral component. Not all surface changes applied in this study did lead to improvement in wear performance. However, this study demonstrates the potential of OxZr and TiN for reducing UHMWPE wear and offers new insights into the effects of wear on TKA.

Malpositioning of Prosthesis: Patient-specific Total Knee Arthroplasty Versus Standard Off-the-Shelf Total Knee Arthroplasty.

INTRODUCTION: A recent study has challenged the premise that a patient-specific (PS)-designed total knee arthroplasty (TKA) component has better clinical survival than an off-the-shelf (OTS) prosthesis. METHODS: We developed the finite element models for PS TKA and OTS TKA with 5° varus and valgus malalignment and 5° internal and external malrotations. RESULTS: Contact stress on the medial side of the insert increased with internal femoral malrotation and varus tibial malalignment, but it decreased with external femoral malrotation and varus tibial malalignment in both PS TKA and OTS TKA. An increase in ligament force occurred in valgus malalignment and external malrotation, and in particular, the force exerted on the medial collateral ligament increased. However, PS TKA provided better biomechanical effects than did the standard OTS TKA with malpositioning in TKA. DISCUSSION: These results emphasize the importance of precise surgical preservation in regard to the TKA position.

Biomechanical Effects of Posterior Condylar Offset and Posterior Tibial Slope on Quadriceps Force and Joint Contact Forces in Posterior-Stabilized Total Knee Arthroplasty.

This study aimed to determine the biomechanical effect of the posterior condylar offset (PCO) and posterior tibial slope (PTS) in posterior-stabilized (PS) fixed-bearing total knee arthroplasty (TKA). We developed ±1, ±2, and ±3 mm PCO models in the posterior direction and -3°, 0°, 3°, and 6° PTS models using a previously validated FE model. The influence of changes in the PCO and PTS on the biomechanical effects under deep-knee-bend loading was investigated. The contact stress on the PE insert increased by 14% and decreased by 7% on average as the PCO increased and decreased, respectively, compared to the neutral position. In addition, the contact stress on post in PE insert increased by 18% on average as PTS increased from -3° to 6°. However, the contact stress on the patellar button decreased by 11% on average as PTS increased from -3° to 6° in all different PCO cases. The quadriceps force decreased by 14% as PTS increased from -3° to 6° in all PCO models. The same trend was found in patellar tendon force. Changes in PCO had adverse biomechanical effects whereas PTS increase had positive biomechanical effects. However, excessive PTS should be avoided to prevent knee instability and subsequent failure.

Patient-specific instrumentation development in TKA: 1st and 2nd generation designs in comparison with conventional instrumentation.

INTRODUCTION: This study was conducted to determine if the difference in magnetic resonance imaging (MRI)-based 2nd generation patient-specific instrumentation (PSI) design affects post-operative restoration of neutral mechanical alignment in total knee arthroplasty (TKA) compared with the 1st generation PSI design and conventional surgical techniques. In addition, it is aimed at elucidating whether PSI improves surgical efficiency with respect to operating room time, estimated blood loss and the number of instrument trays used intra-operatively. MATERIALS AND METHODS: We report our experience in TKA using PSI techniques in 234 patients from August 2012 to March 2015. The patients were divided into 1st (n = 64) and 2nd (n = 70) generation PSI design. The control group (n = 100) underwent TKA with the conventional instrument technique. RESULTS: The mean surgical time was significantly shorter in the 2nd generation PSI design (62.1 ± 12.1 min) than in the control group (80.6 ± 21.7 min; P < 0.001). A mechanical axis malalignment of >3° of the lower limb was observed in 5.7% of the patients in 2nd generation PSI design compared with 26.0% of the control group (P = 0.006). No significant difference in mechanical alignment on post-operative long alignment radiography was found between 20.3% of the patients in 1st generation PSI design and the control group (P = 0.584). CONCLUSION: The 1st generation PSI design did not have a shorter surgical time or improved alignment compared with conventional instrumentation (CI). However, the use of the perfectly fitted 2nd generation PSI design was associated with improvements in both of these measurements. This study emphasizes the importance of PSI design in intra-operative and post-operative outcomes of TKA.