RESUMO
Novel diselenide-linked porphyrin dimers were synthesized under phase-transfer catalysis conditions. The targeted compounds were characterized by (1)H-NMR, high-resolution mass spectrometry, UV/VIS and fluorescence spectroscopies, redox-potential measurements, and elemental analysis. The interaction of the title compounds with DNA was studied using UV/VIS, fluorescence, and circular dichroism (CD) spectroscopies. The relative rates of singlet-oxygen production from the diselenide-linked porphyrin dimers upon photoirradiation were also measured.
Assuntos
DNA/química , Porfirinas/síntese química , Selênio/química , Catálise , Dimerização , Oxirredução , Porfirinas/química , Oxigênio Singlete/químicaRESUMO
Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.