1.
J Med Chem
; 65(16): 11388-11403, 2022 08 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35972896
RESUMO
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that target the adult filarial stage. Herein, we describe the discovery of a series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricides for the treatment of human filarial infections.
Assuntos
Filariose Linfática , Oncocercose , Adulto , Aminas , Humanos
2.
Angew Chem Int Ed Engl
; 41(22): 4233-6, 2002 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12434348