Clinical characteristics and outcome of early-stage diffuse large B cell lymphoma of female genital track: A retrospective study of the Hellenic cooperative lymphoma group.

Involvement of female genital track (FGT) by diffuse large B cell lymphoma (DLBCL) represents an extremely rare diagnosis. Especially data regarding early-stage disease (i.e., IE, IIE) is very limited. Importantly, previous studies showed controversial results about the risk of central nervous system (CNS) relapse in this entity. Herein, we describe one of the largest reported real-world series of patients with early-stage FGT DLBCL aiming to investigate the clinicopathological characteristics, response to therapy and survival outcomes in the era of immunochemotherapy. We analyzed 21 consecutive patients with biopsy proven DLBCL from uterus or ovary classified as stage IE or IIE out of 1905 newly diagnosed DLBCL patients (1.1%). Uterine and ovarian localization was observed in 14 and seven patients, respectively. Median age was 66 years (range 33-96); 9/21 (43%) were <55 years. Regarding Cell of Origin DLBCL subtype, Germinal Center B-cell subtype was found in seven patients, non-GCB in 10 and non-classified in 4 patients. Median follow-up was 57 months and 5-year overall survival, lymphoma specific survival and Freedom from Progression were 78%, 89% and 90%, respectively. There was no correlation of patients' characteristics with survival parameters. Interestingly, none of the patients experienced CNS relapse. Our results indicate that localized FGT DLBCL exhibits a good prognosis and may not increase the risk for secondary CNS involvement.

Greek university student's attitudes and beliefs concerning mental illness and its treatment.

INTRODUCTION: Stigma concerning mental disorder is a widespread phenomenon concerning the beliefs and attitudes of the public toward mental patients with a significant negative impact on state policy and the outcome of the patients. MATERIAL AND METHODS: The study included 1,363 students of the Aristotle University of Thessaloniki. The survey was based on an Internet-based electronic platform. The statistical analysis included analysis of variance (ANOVA) and Yates corrected chi-square test. RESULTS: Approximately, 87% of students responded that they know what mental disorder is, 70% were informed from the Internet, 30% consider mental patients responsible for their condition, more than 95% blame the way they were raised and almost 60% consider mental disorder to be heritable. Only a minority feel negatively with a mental patient around and close to 80% would socialize with them. More than 80% accept the need for psychiatric medication treatment but the opinion is split concerning compulsory treatment, and one-third consider medication to be harmful. DISCUSSION: The results of this study suggest that most students believe they know much about mental illness; however, overall their responses are contradictory. They reply with confidence although they are informed mainly by the media and the Internet in an unreliable way. A number of factors including gender, specific school or personal experience of mental disorder in the family seem to influence the result. A combined educational plus contact might be necessary to reduce stigma, since education alone seems to exert a weak effect.