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1.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-727558

RESUMO

It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the LD50 was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its LD50 was very high over 5 g/kg and any side effects were not found.


Assuntos
Animais , Gatos , Camundongos , Ratos , Pressão Sanguínea , Temperatura Corporal , Contratos , Ingestão de Líquidos , Esofagite , Etanol , Gastrite , Cobaias , Frequência Cardíaca , Intestino Grosso , Dose Letal Mediana , Respiração , Convulsões , Comportamento Estereotipado
2.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-727874

RESUMO

A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes. In the present study, we investigated the pharmacological characterization of the 5-HT-induced contractile response in longitudinal smooth muscle isolated from the feline ileum. Addition of 5-HT into muscle chambers enhanced the basal tone and spontaneous activity in a concentration-dependent manner. The neurotoxin tetrodotoxin did not alter the 5-HT-induced contraction of the longitudinal muscles. Neither atropine nor guanethidine affected the contraction. The 5-HT agonists, 5-methylserotonin hydrochloride and mosapride, also evoked concentration-dependent contractions. The 5-HT-induced contraction was enhanced by the 5HT2 receptor antagonist ketanserin and the 5-HT3 receptor antagonist ondansetron but was inhibited by the 5-HT1 receptor antagonist methysergide and 5-HT4 receptor antagonist GR113808. These results indicate that 5-HT1 and 5-HT4 receptors may mediate the contraction of the 5-HT-induced response and 5-HT2 and 5-HT3 receptors may mediate 5-HT-induced relaxation in feline ileal longitudinal smooth muscles.


Assuntos
Atropina , Benzamidas , Contratos , Trato Gastrointestinal , Guanetidina , Íleo , Indóis , Ketanserina , Metisergida , Morfolinas , Contração Muscular , Músculo Liso , Músculos , Ondansetron , Receptores de Serotonina , Receptores 5-HT1 de Serotonina , Receptores 5-HT3 de Serotonina , Receptores 5-HT4 de Serotonina , Relaxamento , Serotonina , Agonistas do Receptor de Serotonina , Sulfonamidas , Tetrodotoxina
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