Indigenous people doing citizen science to assess water quality using the BMWP in rivers of an arid semi-arid biosphere reserve in Mexico.

Arid and semi-arid areas are among the most threatened ecosystems on the planet. The Tehuacán-Cuicatlán Biosphere Reserve (TCBR), in southeastern Mexico, is an arid and semi-arid area with high biological diversity and human settlements of eight ethnic groups. Two rivers drain the reserve, Río Grande (RG) and Río Salado (RS), which are not subject to water quality monitoring by government agencies; however, measures of water quality of these rivers are needed to focus conservation actions on this resource. This work aimed to test the effectiveness of participatory water quality monitoring with the participation of three actors: Reserve management leaders, local communities, and academics, to monitoring water quality in the rivers of the TCBR. Ninety-two residents were trained to carry out water quality biomonitoring using the Biological Monitoring Working Party (BMWP) index calibrated for the reserve. The BMWP uses macroinvertebrate families to display numerical and categorical water quality scores. Additionally, the Water Quality Index (WQI) was assessed and the Normalized Difference Vegetation Index (NDVI) of the riparian zones was estimated in each study site. The mean WQI scores were 69.24 for RS (no treatment necessary for most crops and necessary treatment for public water supply) and 75.16 for RG (minor purification for crops requiring high-quality water and necessary treatment for public water supply). The BMWP showed five water quality categories (Excellent, Very Good, Good, Fair, and Poor), showing higher water quality scores in the upper portion of the basins and capable of discriminating study sites with lower scores close to human settlements. At one study site, data from participatory monitoring impelled actions taken to address a pollution source and influenced policy focus, reaching the maximum level of participatory-based monitoring. This led to avoid the discharge of wastewater into the river to conserve and protect the water resource. WQI is closely related to BMWP; however, the latter was far more sensitive to detecting areas affected by domestic water discharges. The NDVI presented low values for the TCBR, being lower in RS (the driest area). Although the NDVI showed a weak relationship with BMWP values, areas with higher NDVI values generally achieved higher BMWP values. The results of this study highlight the high sensitivity of the BMWP to detect several water quality conditions in the rivers running through the TCBR when compared to WQI. In addition, the usefulness of biomonitoring using the BMWP index was evident, as well as the importance of the participation of local inhabitants contributing to the knowledge of water quality in biosphere reserves and carrying out timely measures that allow the rivers in these reserves to be maintained in good condition.

Validity and norms for young adults for the Aggie Figures Learning Test.

The Aggie Figures Learning Test (AFLT) is a visual memory assessment tool, which was constructed as an analog to the Rey Auditory Verbal Learning Test (RAVLT). Since the test holds close resemblance to the RAVLT, it is possible to make meaningful comparisons between these two tests. These comparisons are notably relevant in the assessment of material-specific memory impairments in epilepsy. However, the AFLT convergent validity has not yet been established. OBJECTIVE: The purpose of the present study was to demonstrate the convergent validity of the AFLT and to provide norms for an adult population ranging from 18 to 58. METHOD: 140 healthy volunteers participated in the study. They ranged in age from 18 to 58 years, with 12 to 25 years of education. Subjects were assessed with a comprehensive neuropsychological battery which included the ALFT (A version) and the Rey-Osterrieth Complex Figure (ROCF). RESULTS: Positive correlations were found between the scores of both tests for recent memory (r = 0.606, p < 0.01), delayed free recall (r = 0.534, p < 0.01) and recognition memory (r = 0.202, p < 0.05). These results demonstrate the convergent validity of the AFLT. CONCLUSIONS: The AFLT is a visual memory assessment tool with adequate psychometric properties, which allows a comprehensive evaluation of visual memory processes.

Taming the terminological tempest in invasion science.

Standardised terminology in science is important for clarity of interpretation and communication. In invasion science - a dynamic and rapidly evolving discipline - the proliferation of technical terminology has lacked a standardised framework for its development. The result is a convoluted and inconsistent usage of terminology, with various discrepancies in descriptions of damage and interventions. A standardised framework is therefore needed for a clear, universally applicable, and consistent terminology to promote more effective communication across researchers, stakeholders, and policymakers. Inconsistencies in terminology stem from the exponential increase in scientific publications on the patterns and processes of biological invasions authored by experts from various disciplines and countries since the 1990s, as well as publications by legislators and policymakers focusing on practical applications, regulations, and management of resources. Aligning and standardising terminology across stakeholders remains a challenge in invasion science. Here, we review and evaluate the multiple terms used in invasion science (e.g. 'non-native', 'alien', 'invasive' or 'invader', 'exotic', 'non-indigenous', 'naturalised', 'pest') to propose a more simplified and standardised terminology. The streamlined framework we propose and translate into 28 other languages is based on the terms (i) 'non-native', denoting species transported beyond their natural biogeographic range, (ii) 'established non-native', i.e. those non-native species that have established self-sustaining populations in their new location(s) in the wild, and (iii) 'invasive non-native' - populations of established non-native species that have recently spread or are spreading rapidly in their invaded range actively or passively with or without human mediation. We also highlight the importance of conceptualising 'spread' for classifying invasiveness and 'impact' for management. Finally, we propose a protocol for classifying populations based on (i) dispersal mechanism, (ii) species origin, (iii) population status, and (iv) impact. Collectively and without introducing new terminology, the framework that we present aims to facilitate effective communication and collaboration in invasion science and management of non-native species.

Heterocycles in Breast Cancer Treatment: The Use of Pyrazole Derivatives.

Among the aromatic heterocycle rings, pyrazole -a five-membered ring with two adjacent nitrogen atoms in its structure has been postulated as a potent candidate in the pharmacological context. This moiety is an interesting therapeutic target covering a broad spectrum of biological activities due to its presence in many natural substances. Hence, the potential of the pyrazole derivatives as antitumor agents has been explored in many investigations, showing promising results in some cases. In this sense, breast cancer, which is already the leading cause of cancer mortality in women in some countries, has been the topic selected for this review, which covers a range of different research from the earliest studies published in 2003 to the most recent ones in 2021.

Oxidative stress in Physella acuta: An integrative response of exposure to water from two rivers of Atlantic Mexican slope.

Freshwater pollution is a complex mixture of xenobiotics due to the wastewater and the various chemicals routinely applied to agricultural lands that are discharged into water bodies. Xenobiotics can exert damage to the aquatic biota threatening the biodiversity of aquatic ecosystems. The oxidative damage and antioxidant responses have been widely investigated in freshwater organisms, mainly in fish and some invertebrates but in freshwater snails are scarce. This study aimed to assess the oxidative stress exerted by potential toxicity of water from two rivers of the Mexican Atlantic Slope (Tecolutla and Tuxpan rivers) in a freshwater mollusk Physella acuta. Lipid peroxidation level and a battery of antioxidant enzymes (Superoxide dismutase, Catalase and Glutathione peroxidase) were measured in P. acuta. The results are contextualized from an ecological point of view, associating the bioassay results with water quality characteristics. Water samples were obtained from three study sites for each river (in two seasons: Northern wind and dry). Twelve water quality variables were analyzed, and an additional water sample was used to perform a static bioassay for 96 h with snails grown in laboratory. After the exposure, we assessed lipid peroxidation level and the antioxidant responses of P. acuta exposed to water of rivers, and the Integrated Biomarker Response was computed. The highest lipid peroxidation level occurred in organisms exposed to water during the Northern wind season in both rivers. During this season, in the Tecolutla river, the superoxide dismutase activity was able to counteract the lipid peroxidation process, representing an adaptive response. In contrast, in the Tuxpan river, the superoxide dismutase was unable to counteract that process, stimulating CAT and GPx activities. The Integrated Biomarker Response showed that the Tecolutla river had higher values in the upper reaches than the Tuxpan river, showing a decreasing downstream gradient in both seasons. In the Tuxpan river, during the Dry season, the IBR score showed an increasing downstream gradient. During the Northern wind season, the IBR was higher in the upper reaches of both rivers, possibly due to the increased materials transported by runoff from the catchment, which includes a complex mixture of xenobiotics that affects the health of the sentinel species and aquatic biota in general. Based on our results, Physella acuta is proposed as sentinel species.

Historical analysis of an imperiled fish species: environmental variables modeling, biotic interactions, extirpation, and current restricted-range.

BACKGROUND: Analyses of spatial and temporal patterns and interactions are important for determining the abiotic factors limiting populations and the impact from other species and different anthropogenic stressors that promote the extirpation of species. The fish Hubbsina turneri de Buen (1940) was studied as a model species in a historical context at varying locations. Originally distributed only in the Lerma-Chapala basin, the main lake complex in Mexico, this species has not been collected from Lake Cuitzeo (LC) and now is restricted to Lake Zacapu (LZ). At present, the Highland splitfin is classified as critically endangered. METHODS: Historical information of LC and historical and current information from LZ were explored by applying cluster analysis and generalized additive mixed model (GAMM) to describe the biotic interactions among fish species and the relationship between density and environmental variables, respectively. The two lakes' contrasting abiotic/biotic characteristics provided elements to describe some species distribution limits in chemical ion gradients. Extirpation calendar dates were estimated using an optimal linear estimation method. Finally, a bibliographic review was conducted on the causes that promoted the extirpation and restriction of H. turneri and the prognosis for its reestablishment and conservation. RESULTS: Clusters showed the fishes relationship according to their distribution along the lakes. GAMM indicated that high H. turneri density is related to low hardness/fecal coliforms, medium depth/suspended solids, and high oxygen concentration. Estimated extirpation dates were between the years 2013 and 2018. The extirpation was linked to an abrupt drop in the LC volume, water quality degradation, increased biotic interactions within macrophytes habitats with native and introduced species, and fisheries bycatches. The current restricted range of H. turneri resulted from the draining of the larger lake, forcing the remaining populations to small spring-fed remnants. Recent samplings in LZ resulted in a low number of individuals. CONCLUSIONS: The integration of ecological interactions derived from statistical models, extirpation dates from nonparametric tests, and the exhaustive analysis of historical information can be applied to define the current situation of imperiled, ecologically relevant species, in different aquatic ecosystems. We are confident that this general framework is important for determining (1) the requirements and limitations of populations regarding abiotic variables, (2) biotic interactions (trophic and spatial) with native and introduced species, and (3) different anthropogenic stressors within and around the ecosystem. This knowledge will also allow understanding those aspects that contribute to the extirpation of populations and could help the restoration of the habitat and the reintroduction of extirpated species.

Atmospheric pollution assessment using polar graphs and its relationship with the bird community from the Sierra de Guadalupe, Mexico (initial data).

One of the most populated areas of the world is the Metropolitan Zone of the Mexican Valley, which has serious atmospheric pollution problems. To the north of the Metropolitan Zone is the Protected Natural Area Sierra de Guadalupe (PNASG), an area with a high diversity of birds, close to an industrial zone, and poor air quality (AQ). It is known that a poor AQ affects biodiversity. Therefore, this study aimed to evaluate the AQ using O3, CO, NO2, PM10 and PM2.5 polar graphics atmospheric pollutants (PGAP) and the Integrated Air Quality Index (IAQI) to examine its relationship with the structural diversity (SD) and the functional diversity (FD) of the bird community of the PNASG. In autumn-2019 and winter-2020, bird surveys and the PGAP with the pollutant concentrations were performed using data from Mexico City air quality network. The IAQI, SD and FD were estimated. Autumn-2019 registered the worst IAQI (334), the lowest wind speed (1.5 m/s), and the highest PGAP values (90). These worst AQ and the highest PGAP values were outside the PNASG but into a green urban area. This site also showed the highest SD scores (87), reflecting that the green urban areas function as a refuge for birds. The study sites with the best AQ (130.37), the lowest PGAP values (0.1) and the highest FD (0.7) were inside the PNASG. We conclude that a poor AQ minimizes the FD and that the PNASG is an essential buffer and a biological conservation area. The combined use of an integrated index of air quality with the polar graphics and diversity of birds (SD and FD) allow a better interpretation of air quality. It is necessary to establish mechanisms ensuring the conservation of the protected natural areas and green urban areas to improve air quality and biodiversity conservation.

Aquatic macroinvertebrate assemblages in rivers influenced by mining activities.

Mining is one of the major pollution sources worldwide, causing huge disturbances to the environment. Industrial and artisanal mining activities are widespread in Mexico, a major global producer of various metals. This study aimed to assess the ecological impairments resulting from mining activities using aquatic macroinvertebrates assemblages (MA). A multiple co-inertia analysis was applied to determine the relationships between environmental factors, habitat quality, heavy metals, and aquatic macroinvertebrates in 15 study sites in two different seasons (dry and wet) along two rivers running across the Central Plateau of Mexico. The results revealed three contrasting environmental conditions associated with different MAs. High concentrations of heavy metals, nutrients, and salinity limit the presence of several families of seemingly sensitive macroinvertebrates. These factors were found to influence structural changes in MAs, showing that not only mining activities, but also agriculture and presence of villages in the basin, exert adverse effects on macroinvertebrate assemblages. Diversity indices showed that the lowest diversity matched both the most polluted and the most saline rivers. The rivers studied displayed high alkalinity and hardness levels, which can reduce the availability of metals and cause adverse effects on periphyton by inhibiting photosynthesis and damaging MAs. Aquatic biomonitoring in rivers, impacted by mining and other human activities, is critical for detecting the effect of metals and other pollutants to improve management and conservation strategies. This study supports the design of cost-effective and accurate water quality biomonitoring protocols in developing countries.

Temporal distribution patterns of metals in water, sediment, and components of the trophic structure in a tropical coastal lagoon of the Gulf of Mexico.

Trophic transfer and bioaccumulation of trace metals have a profound impact on the structure and function of coastal areas; however, the metal accumulation patterns in detritus-based food webs and the influence of climatic variability have not been thoroughly investigated. The Tampamachoco Lagoon (Gulf of Mexico) is a coastal system impacted by emissions from a thermoelectric plant. We evaluated the spatial-temporal distribution patterns of Al, Cd, Hg, Cr, Cu, and Pb in water, sediments, and in organisms categorized by trophic levels (TLs), trophic guilds, and habitat preferences. The sediments had the highest concentrations of metals with no significant differences between seasons. The indices of geo-accumulation and potential ecological risk classified sediments as "moderately contaminated", evidencing a threat to human health through consumption of detritivores and filter-feeders. The lowest TLs (filter-feeders and detritivorous) reached the maximum Metal Pollution Index in the rainy season. According to discriminant analyses of metals and species, omnivorous and zoobentivorous organisms were associated with Hg during the rainy and dry seasons; while Al, Cd, and Cu were related to low TLs, and seston was associated with Pb. Food web magnification factor analysis showed that: (a) Pb, Cu, and Cr were biodiluted as trophic levels increased; (b) Cd and Hg showed temporal biomagnification trends; (c) Al, Pb, Cu, and Cd showed significant biodilution from the lowest TL to intermediate TLs; and (d) Hg was transferred from the lowest to intermediate TLs with clear biomagnification effects.

Using different multivariate approaches to assess water quality of qanats in arid zones of Southern Central Mexico.

Qanats in the aquifer of the Tehuacán Valley (Mexico) represent an ancient way of using groundwater that is still practiced today. They are used mainly for agricultural irrigation. However, anthropogenic activities have jeopardized the use of these aquifers. We analyzed 24 qanats in the Tehuacán Valley to assess water quality. Based on 24 physicochemical variables, a water quality index (WQI) was constructed on a zero-to-100 scale, divided into five water quality classes. A decision-tree analysis was applied to identify the parameters with the highest influence on the WQI, considering the water quality classes as categorical responses and the values of physicochemical variables as drivers of these categories. We produced interpolation maps to identify trends. The relationship between the WQI and the normalized difference indices of vegetation and salinity (NDVI and NDSI, respectively) was analyzed using a ternary diagram. WQI scores showed that 12.5% of the qanats have very good quality; 25%, good quality; and the remaining (62.5%) range from moderate to unacceptable quality. The CHAID classification-tree method correctly explained 83.3% of the categories, with sulfates, alkalinity, conductivity, and nitrates as the main parameters that explain water quality. WQI was inversely related to NDVI and NDSI, showing seasonal differences. Interpolation maps suggest a better water quality in the northern zone of the aquifer.

Novel ureido-dihydropyridine scaffolds as theranostic agents.

In this work, the synthesis of interesting urea derivatives 5 based on 1,4-dihydropyridines 3 is described for the first time. Considering that both families exhibit potential as drugs to treat various diseases, their activity as anticancer agents has been evaluated in HeLa (cervix), Jurkat (leukaemia) and A549 (lung) cancer cell lines as well as on healthy mice in vivo. In general, whereas 1,4-dihydropyridines show a moderate cytotoxic activity, their urea analogues cause an extraordinary increase in their antiproliferative activity, specially towards HeLa cells. Because of the chiral nature of these compounds, enantiomerically enriched samples were also tested, showing different cytotoxic activity than the racemic mixture. Although the reason is not clear, it could be caused by a complex amalgam of physical and chemical contributions. The studied compounds also exhibit luminescent properties, which allow performing a biodistribution study in cancer cells. They have emission maxima between 420 and 471 nm, being the urea derivatives in general red shifted. Emission quenching was observed for those compounds containing a nitro group (3e,f and 5e,f). Fluorescence microscopy showed that 1,4-dihydropyridines 3a and 3g localised in the lysosomes, in contrast to the urea derivatives 5h that accumulated in the cell membrane. This different distribution could be key to explain the differences found in the cytotoxic activity and in the mechanism of action. Interestingly, a preliminary in vivo study regarding the acute toxicity of some of these compounds on healthy mice has been conducted, using a concentration up to 7200 times higher than the corresponding IC50 value. No downgrade in the welfare of the tested mice was observed, which could support their use in preclinical tumour models.

Magnetic Structures of Mn11Ta4O21 and Interpretation as an Hexagonal A-site Manganite.

Mn11Ta4O21 is presented as the first hexagonal A-site manganite. Based on simple rules, the structure is compatible with a 14H-layer (cchchch)2 stacking sequence that is related to BaVO3 and BaCrO3 high-pressure polymorphs. The A-site overstoichiometry is explained through difference in ionic radii sizes between Ba and Mn. Magnetic properties show two transitions at TN1 = 88 K and TN2 = 56 K. Neutron powder diffraction evidence two magnetic structures with purely antiferromagnetic and ferrimagnetic orders below TN1 and TN2, respectively. A complementary description with 14H-(hhccccc)2 sequence of only Mn octahedra provides a direct comparison with BaMnO3-δ hexagonal perovskites and naturally explains the AFM order. Below TN2 a magneto-elastic coupling along with uniaxial negative thermal expansion are observed.

Ultrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies.

A simple approach to synthesize new highly substituted 4H-pyran derivatives is described. Efficient Et3N acts as a readily accessible catalyst of this process performed in pure water and with only a 20 mol% of catalyst loading. The extremely simple operational methodology, short reaction times, clean procedure and excellent product yields render this new approach extremely appealing for the synthesis of 4H-pyrans, as potentially biological scaffolds. Additionally, DNA interaction analysis reveals that 4H-pyran derivatives behave preferably as minor groove binders over major groove or intercalators. Therefore, this is one of the scarce examples where pyrans have resulted to be interesting DNA binders with high binding constants (Kb ranges from 1.53 × 104 M-1 to 2.05 × 106 M-1).

Assessment of seasonal and spatial variations of biochemical markers in Corydalus sp. (Megaloptera: Corydalidae), a non-conventional biomonitor, in a mountain cloud forest in Mexico.

Rivers are critical ecosystems for protecting and harboring high biodiversity. Tropical rivers particularly are unique for facing extreme climatic events under the current accelerated disruption from human activities. The Bobos-Nautla river basin is exposed to climatic events and disturbances from anthropogenic impacts that stress aquatic organisms. We assessed the health condition of this river system using a non-conventional biomonitor, Corydalus sp., with a set of early-warning biomarkers including lipid peroxidation levels (LPO) and antioxidant activity, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and the neurotransmitter acetylcholinesterase (AChE) considering their spatial and temporal variations. Biomarkers and water quality parameters were analyzed, and the integrated biomarker response (IBR) was assessed as a stress index. Biomarkers showed no significant spatial differences; however, a high-stress period during the rainy season was detected, evidenced by the highest LPO levels; this period is related to the leaching of allochthonous materials from agricultural and urban zones. The peak IBR value during the rainy season confirmed the seasonality of biomarkers. A slight increase in IBR was recorded in lowlands, seemingly associated with agricultural land and human settlements. A principal component analysis showed nutrient enrichment during the rainy season and depletion during the cold-dry season, together with a peak activity of antioxidant enzymes. These results highlight the importance of climatic events such as the rainy season on the health condition of Corydalus sp., which is highly sensitive to the complex mixtures of pollutants that enter the waterbody during extreme climatic events, promoting oxidative stress. Our results also showed the ability of Corydalus sp. to recover and return to a basal level.

Effects of Bisphenol A on Foxl2 gene expression and DNA damage in adult viviparous fish Goodeaatripinnis.

Bisphenol A (BPA) is an emerging pollutant of global concern. Viviparous fish Goodea atripinnis is endemic to the Central Mexican Plateau where BPA was detected; however, few studies examined the influence of this chemical on native viviparous fish. The effects of BPA (sublethal dose) were determined on DNA integrity and Foxl2 expression in G. atripinnis gonads, and interactions of BPA with FOXL2 protein. Genotoxicity analysis revealed that % comets, at 14 and 28 days and comet tail length (at 14 days) were significantly higher in exposed compared to controls. In general, the % DNA tail was not markedly higher in BPA-treated fish; however, tail moment related to tail length exhibited significant increases in DNA damage. RT-qPCR assays showed Foxl2 overexpression after 14 and 28 days of exposure in females; while in males, Foxl2 was overexpressed after 28 days. In silico analysis demonstrated that BPA interacted with seven residues located in FOXL2 homeodomain. In summary, sublethal BPA doses induced DNA damage and changes in Foxl2 expression in gonadal cells of G. atripinnis, which may adversely affect reproduction in BPA-exposed wild populations. Foxl2 overexpression and BPA-FOXL2 interaction suggested alterations in processes involving Foxl2. Viviparous fish may thus serve as potential non-conventional models for assessing pollutants effects.

Asymmetric Organocatalyzed Aza-Henry Reaction of Hydrazones: Experimental and Computational Studies.

The first asymmetric catalyzed aza-Henry reaction of hydrazones is presented. In this process, quinine was used as the catalyst to synthesize different alkyl substituted ß-nitrohydrazides with ee up to 77 %. This ee was improved up to 94 % by a further recrystallization and the opposite enantiomer can be obtained by using quinidine as the catalyst, opening exciting possibilities in fields in which the control of chirality is vital, such as the pharmaceutical industry. Additionally, experimental and ab initio studies were performed to understand the reaction mechanism. The experimental results revealed an unexpected secondary kinetic isotope effect (KIE) that is explained by the calculated reaction pathway, which shows that the protonation of the initial hydrazone and the C-C bond forming reaction occur during a concerted process. This concerted mechanism makes the catalysis conceptually different to traditional base-promoted Henry and aza-Henry reactions.

Distintos estilos del sentido del humor y su relación con las conductas agresivas físicas y verbales en adolescentes argentinos / Different styles of sense of humor and their relationship with aggressive physical and verbal behavior in Argentine adolescents

Resumen El objetivo de este trabajo es estudiar la relación entre los estilos de humor adaptativos (humor afiliativo y humor mejoramiento personal) y desadaptativos (humor agresivo y humor descalificación personal) propuestos por Martin (2003), y las conductas agresivas físicas y verbales. Se trabajó con una muestra de 100 adolescentes argentinos, entre 16 y 18 años, de ambos sexos, quienes respondieron dos escalas: el Cuestionario de Agresividad Física y Verbal (Caprara y Pastorelli, 1993, versión española de del Barrio, Moreno Rosset, López y Martínez, 2001), y la versión adaptada al español por Cayssials (2004) de la Escala de Estilos de Humor (Martin, 2003). Los resultados indican que el humor agresivo predice positivamente las conductas agresivas en general, tanto verbales como físicas, mientras que el estilo de humor de mejoramiento personal mitiga las conductas agresivas evaluadas en general y las conductas agresivas verbales. Por último, las conductas agresivas físicas únicamente fueron predichas por el estilo de humor agresivo.

Abstract The sense of humor gives a new perspective of life by turning the person into a spectator of what is happening, being able to laugh at oneself and to what happens to one. Because of that, it is considered that humor allows us to face problematic situations in a different way. Carbelo and Jáuregui (2006) argue that sense of humor is not a mere remedy to prevent or help overcome disease; instead, it has the capacity to promote greater well-being, enjoyment of life, growth towards greater humanity and fulfillment. These same authors add that sense of humor is a unique trait of the human species and it is possessed by all human beings of different cultures (Carbelo y Jáuregui, 2006). While each culture has its own rules about which facts or situations may be the object or cause of humor, "both humor and laughter are universal" (Cassaretto y Martínez, 2009, p. 289). Although humor has been associated with psychological, physical and social well-being, not all research show consistent results. This is because sense of humor does not imply only positive components, but also negative components (Martin, 2003; Cassaretto y Martínez, 2009). In general, the different studies carried out have perceived sense of humor as a positive feature with the potential to generate positive effects. However, there are negative elements of humor that have a negative correlation with psychological well-being (Martin, 2003; Grimshaw, Kirsh, Kuiper y Leite, 2004). Therefore, it is important to be able to consider the sense of humor not as a one-dimensional construct (taking into account only its positive components), but to be able to focus on a multi-dimensional approach capable of considering all the characteristics and consequences -positive and negative- of it. Martin (2003) postulates that humor is a personality trait composed of either healthy or adaptive components and of unhealthy or unadaptable components. This author proposes the following classification: Adaptive humor is formed by affiliative humor (the tendency to say funny things, to make jokes, and spontaneous and witty jokes to amuse other people) and self-enhancing humor (it implies having fun with the incongruities of life even in adversity and using humor as a strategy to face the vicissitudes), and unadaptive humor is formed by aggressive humor (the tendency to use humor for the purpose of criticizing or manipulating others by resorting to sarcasm, bothering with jokes, ridiculing others) and self-defeating humor (people who use this kind of humor are self-deprecating, make or say funny things at the expense of themselves and laugh with others while ridiculing or belittling). The aim of this work is to study the relationship between these two types of humor and physical and verbal aggressive behaviors. We worked with a sample of 100 adolescents from Argentina of both sexes, aged between 16 and 18 years, of the middle socioeconomic strata of Buenos Aires, Argentina. All participants responded to two scales: the questionnaire of physical and Verbal aggression (Caprara y Pastorelli, 1993, Spanish version of Barrio, Moreno Rosset, López Martínez, 2001), and the version adapted to Spanish by Cayssials (2004) of the scale of humor styles (Martin, 2003). The results indicate that aggressive humor positively predicts aggressive behaviors evaluated in a general way, and aggressive behaviors verbal and physical evaluated specifically. On the other hand, personal improvement humor style mitigates general aggressive behaviors and verbal aggression specifically. Finally, aggressive physical behaviors were only predicted by the aggressive humor style.

Projected impact of global warming on the distribution of two pocket mouse species with implications on the conservation of Heteromys nelsoni (Rodentia: Heteromyidae)

Introduction: Understanding how species respond to climate change is critical for implementing conservation strategies. Objective: We explain through potential distributions and changes in altitudinal variation, the possible impacts of climate change in an endangered micro-endemic rodent of Mexico with narrow altitudinal range, Heteromys nelsoni and a rodent with a wide distributional and altitudinal range, Heteromys goldmani. Methods: We obtained historical and current records of both Heteromys species. Potential distribution models were generated using Maxent, including altitudes for each species and bioclimatic layers. We determined the Extent of Occurrence and Area of Occupancy for H. nelsoni according to the criteria of the IUCN in order to generate information about its risk status. Results: The altitude is not a variable that determines a shift in the distribution caused by climate change. In contrast, the temperature and precipitation are important for the potential distribution of both Heteromys species. The future changes in climatic conditions could reduce the area of suitable habitat for both species. Conclusions: The distribution surface is not greater than 33.44 km2 for H. nelsoni. Therefore, is urgent to re-evaluate their conservation status by the IUCN, mainly in its B criterion, and to take specific actions for their conservation. We suggest the creation of a terrestrial protected area.

Introducción: El entendimiento de cómo las especies responden al cambio climático es crítico para la implementación de estrategias de conservación. Objetivo: Explicar a través de distribuciones potenciales y cambios en la variación altitudinal, los posibles impactos del cambio climático en un roedor micro endémico de México, en peligro de extinción y con un rango altitudinal estrecho, Heteromys nelsoni y un roedor con una amplia distribución y rango altitudinal, Heteromys goldmani. Metodología: Obtuvimos registros históricos y actuales de ambas especies. Los modelos de distribución potencial se generaron utilizando Maxent, incluyendo altitudes y capas bioclimáticas. Determinamos la extensión de su presencia y el área de ocupación para H. nelsoni según los criterios de la IUCN, para generar información sobre su estado de riesgo. Resultados: La altitud no es una variable que determina un cambio en la distribución causada por el cambio climático. En contraste, la temperatura y precipitación son importantes para la distribución potencial de ambas especies de Heteromys. Los análisis sugieren que los cambios futuros en las condiciones climáticas podrían reducir el área de hábitat adecuado para ambas especies. Conclusión: La superficie de distribución de H. nelsoni no es mayor a 33.44 km2. Es urgente reevaluar su estado de conservación de la UICN, principalmente en su criterio B y tomar medidas específicas para su conservación. Sugerimos la creación de un área terrestre protegida.

First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives.

Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40⁻54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.