Unveiling the Drug Formulation Code: A Journey to Three-Dimensional Precision.

Magistral formulations emerged years ago and were of great help in the personalization of treatments for patients. Over time, innovation began in this area with new technologies such as three-dimensional (3D) printing, which has brought greater benefits, ease of preparation, new scopes, and even cost reduction. Three-dimensional printing of medicines opened the way to create personalized multi-dose, controlled-release, multi-drug tablets, among others. In addition, this technology manages to be more specific in adjusting pharmacokinetics, doses, and even organoleptic qualities, which is precisely what is sought since the medication is being personalized for a patient due to a particular case or condition. Throughout the research, some studies can be observed that function as a base that provides safety and effectiveness for the subsequent use of other pharmaceuticals in the 3D printing of medicines.

Revolutionizing Healthcare: Qure.AI's Innovations in Medical Diagnosis and Treatment.

Qure.AI, a leading company in artificial intelligence (AI) applied to healthcare, has developed a suite of innovative solutions to revolutionize medical diagnosis and treatment. With a plethora of FDA-approved tools for clinical use, Qure.AI continually strives for innovation in integrating AI into healthcare systems. This article delves into the efficacy of Qure.AI's chest X-ray interpretation tool, "qXR," in medicine, drawing from a comprehensive review of clinical trials conducted by various institutions. Key applications of AI in healthcare include machine learning, deep learning, and natural language processing (NLP), all of which contribute to enhanced diagnostic accuracy, efficiency, and speed. Through the analysis of vast datasets, AI algorithms assist physicians in interpreting medical data and making informed decisions, thereby improving patient care outcomes. Illustrative examples highlight AI's impact on medical imaging, particularly in the diagnosis of conditions such as breast cancer, heart failure, and pulmonary nodules. AI can significantly reduce diagnostic errors and expedite the interpretation of medical images, leading to more timely interventions and treatments. Furthermore, AI-powered predictive analytics enable early detection of diseases and facilitate personalized treatment plans, thereby reducing healthcare costs and improving patient outcomes. The efficacy of AI in healthcare is underscored by its ability to complement traditional diagnostic methods, providing physicians with valuable insights and support in clinical decision-making. As AI continues to evolve, its role in patient care and medical research is poised to expand, promising further advancements in diagnostic accuracy and treatment efficacy.

Amivantamab: A Novel Advance in the Treatment of Non-small Cell Lung Cancer.

Amivantamab is a fully human bispecific monoclonal antibody indicated for treating patients with specifically large cell lung cancer. Its dosage is based on the patient's initial body weight and is administered via intravenous infusion after dilution. Therefore, this drug is given as a strategy due to the great need for a molecule targeting epidermal growth factor receptor (EGFR) and the mesenchymal-epithelial transition factor (MET), as acquired resistance to tyrosine kinase inhibitors (TKIs) was observed in the treatment of large cell lung cancer. This article encompasses a review of the benefits of amivantamab for patients with non-small cell lung cancer (NSCLC). This drug is the first therapy directed against this specific mutation, and unlike others, it could bind to two genetic receptors, whereas antibodies, in general, are directed toward a single receptor.

School Nurse Practice: A Descriptive Spanish Study.

This study aimed to describe the profile and practices of school nurses working at a network of educational centers in Spain. This was a descriptive study of the documented actions of 107 school nurses between September 2018 and June 2021 in 54 educational centers (55.6% private and 44.4% subsidized). The profile of the school nurses was young (average age 33.8 [standard deviation (SD) = 7.7] years) and predominantly female (91.6%) with a diverse and multidisciplinary education, primarily at the postgraduate level (specialized mainly in emergency care, nursing/school health, and pediatrics/neonatology). They carried out 256,499 interventions. The most frequent types of incidents they treated were accidents (30.4%) and disease-related episodes (22.2%). The interventions were usually brief (average time 7.7 min) and were resolved by the school nurse (99.1%), and the main recipients were students (87.3%). The highest incidence of interventions occurs during breaks between classes. Acute interventions occupied most of the school nurses' time, leaving little opportunity for health education (0.3%). School nurses played an important role in preserving and promoting the health of school populations and cost-savings to healthcare systems with the actions that they performed. Descriptions of these actions are essential when advocating for the continuation and expansion of school nursing services.

Value-Based Healthcare in Ostomies.

In order to achieve significant improvements in quality, cost, and accessibility (the health "iron triangle"), innovation in organizational and service delivery models is necessary to increase the value of healthcare. The aim of this study is to evaluate the efficiency of a model of organizational innovation based on advanced practice nurse in the care of people with ostomies (APN-O) versus usual care. An observational, exploratory, analytical, prospective study with a six-month follow-up was carried out at 12 hospitals that implemented this model in Andalusia. A total of 75 patients who had undergone a digestive elimination ostomy and/or a urinary ostomy were followed for six months. Clinical outcomes, healthcare resources, health-related quality of life, and willingness to pay (WTP) were analyzed. The economic evaluation was conducted from a societal perspective, including healthcare costs and indirect costs. The cost difference between the two models was €136.99 and the quality-adjusted life year (QALY) gained was 0.05965 (€2297 per QALY gained). At six months, the mean of WTP was €69 per APN-O consultation. This model contributes to increasing the value-based healthcare in ostomies. Results of this study suggested that APN-O is an effective patient management model for improving their health status and is highly efficient.

Evaluation of the ultrasound effect on treated municipal wastewater.

In this research, ultrasound (US; 26 kHz) application was evaluated as tertiary treatment of treated municipal wastewater coming from conventional activated sludge (AS) and constructed wetland (CW) systems. The degree of disinfection was evaluated through the total (TC) and faecal (FC) coliforms and by somatic coliphages (SCs) determinations. The experiments were carried out without temperature control at times of 200, 400 and 600 s and with temperature control (298.1 K) at 600, 1200 and 1800 s. Changes in the concentrations of C, N and P were also studied. The results shown that treatment without temperature control allowed 100% inactivation for TC, FC and SC at 600 s, while maximum with temperature was achieved at 1800 s. Temperature was an important factor influencing pathogens inactivation. In both cases, microorganism concentrations complied with different international guidelines for the reuse of treated wastewater. At 1800 s sonication concentrations of biochemical oxygen demand, chemical oxygen demand and total phosphorus were reduced 39.5, 39.4, 50.0 and 37.3% TN in the AS-treated water and 24.0, 49.8, 20.2 and 7.7% in the CW-treated water, respectively. In both cases, the formation of H⋅ and OH⋅ radicals is most likely related to the observed pollutants removal. While energy consumption of ultrasound was higher than other advanced treatments such as electrocoagulation, its implementation allows the simultaneous removal of pathogens and organic pollutants without the generation of toxic by-products. In conclusion, ultrasound can be implemented as tertiary treatment of municipal wastewater for the removal of biological and organic pollution, according to reuse guidelines in terms of pathogens presence.

Cardiometabolic and Muscular Fatigue Responses to Different CrossFit® Workouts.

CrossFit® consists of workouts of the day (WODs) in which different exercises are conducted at high intensity with minimal or no rest periods. This study sought to quantify exercise intensity and muscular fatigue in the three CrossFit® session modalities: gymnastics (G), metabolic conditioning (M) and weightlifting (W). Thirty two, young, strength-trained, healthy men completed the three WODs: G ("Cindy"), M (double skip rope jumps) and W (power cleans). The variables measured in the sessions were: mean heart rate (HR), rate of perceived exertion (RPE), blood lactate [lactate], and jump height (H), average power (AP) and maximum take-off velocity (Vmax) in a counter movement jump test. In all three WODs, elevated HR values (≥90% of the theoretical HRmax) were recorded at the time points mid-session and end-session. Mean RPEs were 17.6 ± 1.6 (G WOD), 16.0 ± 2.3 (M WOD), and 15.7 ± 2.0 (W WOD). Postexercise [lactate] was higher than 10 mmol·L-1 for the three WODs. Following the G ("Cindy") and W (power cleans) WODs, respectively, significant muscular power losses were observed in H (7.3% and 8.1%), Vmax (13.8% and 3.3%), AP relative (4.6% and 8.3%) and AP total (4.2% and 8.2%) while losses in the M WOD were not significant (p > 0.05). A vigorous intensity of exercise was noted in all three WODs, with greater mean HRs detected in the "Cindy" and skip rope WODs than power clean WOD. Muscular fatigue was produced in response to the "Cindy" and power clean WODs but not the skip rope WOD.

Inhibition of Listeria monocytogenes in Fresh Cheese Using Chitosan-Grafted Lactic Acid Packaging.

A chitosan from biologically obtained chitin was successfully grafted with d,l-lactic acid (LA) in aqueous media using p-toluenesulfonic acid as catalyst to obtain a non-toxic, biodegradable packaging material that was characterized using scanning electron microscopy, water vapor permeability, and relative humidity (RH) losses. Additionally, the grafting in chitosan with LA produced films with improved mechanical properties. This material successfully extended the shelf life of fresh cheese and inhibited the growth of Listeria monocytogenes during 14 days at 4 °C and 22% RH, whereby inoculated samples with chitosan-g-LA packaging presented full bacterial inhibition. The results were compared to control samples and commercial low-density polyethylene packaging.

Cuidadoras inmigrantes: trabajo emocional / Imigrantes Cuidadoras: trabalho emocional / Inmigrants caregivers: emotional labor

Los cambios de carácter demográfico, económicos, socioculturales y sanitarios propician la emergencia de una nueva figura de cuidadores: el cuidador contratado, cubierto, en general, por mujeres inmigrantes. El presente artículo trata de un estudio que pretende indagar sobre esta nueva realidad, centrándose, fundamentalmente, en conocer las vivencias y emociones de las cuidadoras inmigrantes en su relación con las personas cuidadas y su entorno. El estudio, de corte cualitativo, recoge a través de testimonios directos de las cuidadoras, lo que constituye su experiencia vivida; es decir, los relatos sobre un contexto difícil y complejo, donde se cruza una doble necesidad de afecto: de una parte, la de quienes sufren el duelo migratorio, por el alejamiento de los suyos, por la dureza y la precariedad de su condición de migrantes y por otra parte, la de quienes en la vejez, más allá de la dependencia física, sufren de soledad. Se evidencia el carácter afectivo y relacional del cuidado y las aportaciones positivas de estas mujeres inmigrantes a una situación característica de las sociedades globales, y con poblaciones envejecidas (AU)

The changes in demographic, economic, socio-cultural and health foster the emergence of a new set of caregivers: the hired caregiver, covered generally by immigrant women. This article is a study that aims to inquire into this new reality, focusing mainly on knowing the experiences and emotions of immigrant carers in relation to people and their environment maintained. The study, a qualitative research, collected through direct testimony of caregivers, which is their lived experiences, that is, the stories of a difficult and complex context, where it crosses a double need for affection: on one hand, the one of those suffering bereavement of immigration, by the distancing of their own family, by the harshness and precariousness of their migrant status and on the other hand, those who in old age, beyond physical dependence, suffer from loneliness. It demonstrates the emotional and relational nature of care and the positive contributions of these immigrant women to a situation characteristic of global societies, and with aging populations (AU)

As mudanças de caráter demográfico, económico, socio-culturais e de cuidados de sáude, propiciam a aparição de uma nova figura de cuidadores: o cuidador contratado, posto de trabalho, em regra geral, ocupado por mulheres imigrantes. O presente artigo pretende indagar sobre esta nova realidade, procurando fundamentalmente conhecer as vivência se emoções das cuidadoras imigrantes e a sua relação com as pessoas a que cuidam e os meio envolvente.O estudo de caráter qualitativo, recolhe através de testemunhos diretos das cuidadoras,o que constitui a sua experiência vivida; queristo dizer, os relatos sobre um contexto difícile complexo, donde se cruzam uma necessidade dupla de afeto: por um lado, as que sofrem um «luto migratório», pela separação dos seus famiiares, pela dureza e precariedade de sua condição de imigrantes, e por outro lado, a dequem na velhice, para além da dependência física, sofrem de solidão. Torna-se evidente o caráter afetivo e de relação do cuidado e as contribuições positivas destas mulheres imigrantes a uma situação caraterística das sociedades globais, e com populações envelhecidas (AU)