Evolution of lead toxicity in a population of children.

A 3 years study was conducted to determine the evolution of blood lead concentrations (PbB) and free erythrocyte protoporphyrins (FEP) as indicators of absorption and biochemical damage in children (7-12 years old) living within one kilometer of a metallurgic factory that processes lead in Torreón, Coahuila, México. In addition, neuromuscular conduction velocity, motor coordination and IQ where determined as indicators of physiological damage. During this period of time the children showed increased lead blood concentrations of 19.2 +/- 4.5 micrograms dl-1 at the beginning of the study to 27.5 +/- 4.9 micrograms dl-1 at the end. Likewise, FEP increased from 56.6 +/- 20.0 micrograms dl-1 to 92.9 +/- 28.9 micrograms dl-1. Physiological damage was evident since motor coefficients as well as IQ tests were reduced significantly when compared to children (7-12 years old) living 4.5 km away from the factory who showed PbB = 8.9 +/- 1.3 micrograms dl-1 and FEP = 16.9 +/- 4.7 micrograms dl-1 throughout the study. Based on these data it was possible to define three different groups with regards to lead toxicity sensitivity.

[2 cases of transposition corrected in adulthood. The value of computed tomography and isotopic angiography and a review of the literature]. / Dos casos de transposición corregida en la edad adulta. Interés de la tomografía computadorizada y la angiografía isotópica y revisión de la literatura.

Corrected transposition of the great arteries is an unusual congenital heart defect, above all at ages over 40. Echocardiography and invasive angiography are still cornerstones for its diagnosis. However other non-invasive techniques, such radionuclide angiocardiography and computed tomography, not so used in this malformation, can help us in its detection. We present 2 cases of corrected transposition of the great arteries in adults in which these methods were used and review the literature.