RESUMO
PResentamos un caso de dermatofibroma epitelioide rico en células granulares. Solamente se han descrito 11 casos de dermatofibroma de células granulares, de los cuales sólo tres tienen rasgos epitelioides. Es importante reconocer este subtipo de dermatofibroma, ya que puede confundirse con un gran número de procesos benignos o malignos, de diferente aplicación pronóstica y terapeútica (AU)
Assuntos
Adulto , Masculino , Humanos , Tumor de Células Granulares/complicações , Tumor de Células Granulares/diagnóstico , Tumor de Células Granulares/etiologia , Tumor de Células Granulares/patologia , Leiomioma Epitelioide/diagnóstico , Leiomioma Epitelioide/etiologia , Leiomioma Epitelioide/cirurgia , Neoplasias Cutâneas/cirurgia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Histiocitoma Fibroso Benigno/diagnóstico , Histiocitoma Fibroso Benigno/cirurgia , Histiocitoma Fibroso Benigno/etiologia , Histiocitoma Fibroso Benigno/patologia , Histiocitoma Fibroso Benigno/química , Prognóstico , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/patologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/etiologia , Biomarcadores Tumorais/química , Biomarcadores Tumorais , Imuno-Histoquímica/métodosRESUMO
We report 2 patients without a history of acute gouty arthritis showing tophi located only on the fingertips, an unusual location. A review of the literature found a few similar reports; these patients might represent a subgroup of gout characterized by: (1) elderly patients, from the 7th to 9th decades; (2) hyperuricemia; (3) absence of a history of acute gouty arthritis; (4) tophi in the fingertips or fingerpads; (5) chronic renal failure, and (6) all taking drugs or suffering from a disease that affects urate renal excretion.
Assuntos
Dermatoses da Mão/diagnóstico , Idoso , Feminino , Dedos , Dermatoses da Mão/etiologia , Dermatoses da Mão/metabolismo , Humanos , Masculino , Ácido Úrico/análiseRESUMO
A forty-two-year-old male recipient of a cadaver renal transplant showed multiple nodulocystic lesions on his back and lateral aspects of his neck four months after beginning immunosuppressive therapy with cyclosporine A and prednisone. Results of histopathologic studies revealed that they were epidermoid infundibular cysts. We note the relationship between this clinical appearance and cyclosporine A, as well as this agent's cutaneous side effects.
Assuntos
Ciclosporina/efeitos adversos , Cisto Epidérmico/induzido quimicamente , Transplante de Rim , Dermatopatias/induzido quimicamente , Adulto , Ciclosporina/farmacologia , Cisto Epidérmico/patologia , Humanos , Masculino , Dermatopatias/patologiaRESUMO
We report a stellate-cell dermal tumour which was studied by immunohistochemistry and electron microscopy. The stellate morphology of the tumour cells appeared to be due to retraction of their cytoplasm resulting in the emergence of intercellular spaces. Results of the immunohistochemical investigations were consistent with a neural tumour, but we could not assign it to any particular category of the known neural tumours. Therefore we have designated this tumour as an unusual, benign, neural-tumour with stellate-cell morphology.
Assuntos
Perna (Membro) , Neoplasias de Tecido Nervoso/patologia , Neoplasias Cutâneas/patologia , Feminino , Humanos , Técnicas Imunoenzimáticas , Microscopia Eletrônica , Pessoa de Meia-Idade , Neoplasias de Tecido Nervoso/metabolismo , Neoplasias Cutâneas/metabolismoRESUMO
Four cases of epidermotropically metastatic carcinoma are reported. One of them originated from a breast adenocarcinoma; in two other cases, the primary tumor was located in the large intestine; and, in the fourth case, the primary malignancy was a laryngeal squamous cell carcinoma. Clinically, the cutaneous metastases were nodular lesions and histologically, in addition to the involvement of the dermis by malignant cells, in three cases there was intraepidermal involvement by glandular structures. In the fourth case, the cutaneous metastatic tumor cells showed striking "folliculotropism." We review the literature of epidermotropically metastatic carcinoma and discuss its differential diagnosis.
Assuntos
Neoplasias Cutâneas/secundário , Idoso , Neoplasias da Mama/patologia , Feminino , Humanos , Neoplasias Intestinais/patologia , Neoplasias Laríngeas/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologiaRESUMO
We describe a patient who developed a pigmented plaque on the anterior aspect of his right knee clinically mimicking angiokeratoma circumscriptum or malignant melanoma. Histopathological examination demonstrated a multinodular hemosiderotic dermatofibroma in which the cellular tumor islands were separated by areas of hyalinized collagen. Multinucleated giant tumor cells were found in the lumen of a medium-size vein underlying the tumor. The differential diagnosis of angiomatoid malignant fibrous histiocytoma, a tumor with clinical and morphologic similarities, is discussed.