[Comparison between gastric and esophageal mechano-sensitivity in patients with functional dyspepsia]. / Comparación de la mecanosensibilidad gástrica y esofágica en pacientes con dispepsia funcional (D.F.).

UNLABELLED: Patients with non ulcer dyspepsia (NUD) and lowered mechano sensitivity thresholds in stomach may have lowered mechano sensitivity thresholds in oesophagus also. The aim was to check this hypothesis. METHODS: 39 patients with NUD (11 men and 24 women, mean age 57 years, SEM 3.72, range 17-86) and 20 controls (10 men, 10 women, mean age 49.3 years, SEM 3.72, range 31-66) were studied. Organis diseases were discarded. Gastric mechano sensitivity was studied with a latex balloon of low compliance, 8 cm length, connected to a manometer. Balloon was inflated "in ramp" at 10 ml/sec, and "first sensation", discomfort", and "pain" were registered. At 900 ml inflation was stopped if pain was not evoked. Oesophageal mechano sensitivity was studied with another latex balloon of low compliance which, after inflated with 15 ml. of air, was 3.5 cm. in diameter. Esophageal balloon was inflated "in ramp" (1 ml/sec) up 15 ml. and deflated in 2 cm step from 36 to 22 cm from SDA. Inflation was stopped when symptoms (pain or discomfort were evoked. Oesophageal acid perfusion test was performed. RESULTS: 83.4% of controls completed up 700 ml. of gastric distension vs. 35.9% of patients with NUD (p > 0.001). No significative differences in intra-balloon pressure slope were observed between both groups. 79.2% of NUD patients had chest pain with oesophageal ballon distension = < 7 ml. vs. 5% in controls (p > 0.001). Mean volumes were 7.03 ml. (NUD) and 11.9% (controls) (p = 0.001), 63% of dyspeptic patients with lowered gastric sensitivity thresholds (< 700 ml) had oesophagic symptoms with inflation volumes = < 7 ml. There was a positive correlation in stomach and oesophageal mechano sensitivities variations (r = 0.75, +/- 0.58, p > 0.01). When analyzed with that results, oesophageal acid perfusion test showed 38.5% of "mixed sensitivities" (both mechano- and chemo-), 30.7% of "mechano sensorials" (negative acid test, positive balloon test), and 10.3% of :chemo sensorials" (positive acid test only). In 20.5% both tests were normal at the moment they were done. These results agreed with our previous experiences in oesophagus. CONCLUSIONS: It was concluded that a significative proportion of NUD patients had lowered thresholds for mechano stimulation of stomach and oesophagus at the time that both tests were done. Such alterations support the hypothesis that a more general mechano-sensitivity alteration is present in patients with NUD.

[Electrogastrography and gastric emptying in non organic dyspepsia]. / Electrogastrografía y vaciamiento gástrico en pacientes con dispepsia no orgánica.

UNLABELLED: Electrogastrography allows to determinate the dominant frequency of gastric E.C.A. (electrical control activity). The aim was to investigate the gastric E.C.A. in a population of patients suffering from non-organic dispepsia (N.O.D.). Eighteen controls (9 males, 9 females, mean age 46.4 years old, SEM 3.72, range 24-72) and 52 dyspeptic patients (18 males, 34 females, mean age 54.19 years old, SEM 2.38, range 17-86) were studied. Two skin surface electrodes Ag-2ClAg were placed on epigastric area following a probabilistic antral axe. Reference electrode was placed on the right quadrant skin. In 5 patients, recordings with needle and cutaneous electrode were compared. Analogic waves were filtered, digitalized and processed. Signals were analyzed using F.F.T. (Fast Fourier Transformated) Only the predominant frequency in each block was considered, and percentage of total abnormalities on total recording time lesser than 2 c.p.m. or more than 4 c.p.m. was accepted. Recording were taken in fast time during 30 minutes, and 30 minutes after a meal containing 230 Cal. Running spectral analysis with F.F.T. In 43 non-selected patients the gastric emptying time of a mixed meal marked with 99 Tc in the solid phase was studied. RESULTS: 60.45% showed delayed gastric emptying. Mean of fast E.C.A. was 2.99 c.p.m. in controls, Vs 3.34 c.p.m. in dispeptic patients (p > 0.001). In the post-prandial period, mean of E.C.A. was 3.53 c.p.m. in N.O.D., and these differences were not significatives ("t", NS). 22% of controls showed isolated periods of tachygastria, but never more than 8% of the total recording time. It was seen seven six and forty five percent of arrhythmias were observed (71.15% tachygastria, 4.76% bradygastria, and 19.23% mixed) during post prandial recording in N.O.D. 48% of tachygastrias were between the range 30-60% of the time recording. Ninety six and one percent of patients with abnormal gastric emptying had gastric arrhythmias (0.05 > p > 0.02) Vs 50% in patients with normal gastric emptying. Needle recording increased about 200-300% the signal power. It would be the better choice in cases of hairy abdominal skin. CONCLUSIONS: a) More than 76% of patients with N.O.D. had abnormal recording of E.C.A. beyond these observed in controls; b) tachygastria was the more frequent abnormality observed; c) the more severe clinical cases were associated with bradygastria; d) No association between symptoms and abnormal gastric emptying was found; e) E.G.G. abnormalities were seen in 96% of patients with abnormal gastric emptying, Vs 50% in normal gastric emptying; f) Needle electrodes let a better recording of E.G.G. signal; g) No association was found between abnormalities in gastric emptying and/or E.G.G., and clinical subtypes of Dyspepsia.

Comparación de la mecanosensibilidad gástrica en pacientes con dispepsia funcional (D.F.) / Comparison between gastric and esophageal mechano-sensitivity in patients with functional dyspepsia

Patients with non ulcer dyspepsia (NUD) and lowered mechano sensitivity tresholds in stomach may have lowered mechano sensitivity treholds in oesophagus also. The aim was to check this hypothesis. Methods: 39 patients with NUD (11 men and 24 women, mean age 57 years, SEM 3.72, range 17-86) and 20 controls (10 men, 10 women, mean age 49.3 years, SEM 3.72, range (31-66) were studied. Organis diseases were discarded. Gastric mechano sensitivity was studied with a latex ballon of low compliance, 8 cm lenght, conected to a manometer. Ballon was inflated "in ramp"at 10 ml/sec. and "first sensation", disconfort", and "pain" were registered. At 900 ml inflation was stopped if pain was not evoked. Oesophageal mechano sensitivity was studied with another latex ballon of low compliance which, after inflated with 15 ml. of air, was 3.5 cm. in diameter. Esophageal ballon was inflated "in ramp" (1 ml/sec) up 15 ml. and deflated in 2 cm step from 36 to 22 cm from SDA. Infaltion was stopped whrn symptoms (pain or disconfort were evoked. Oesophageal acid perfusion test was performed. Results: 83.4 per cent of controls completed up 700 ml. of gastric distension vs. 35.9 per cent of patients with NUD (p>0.001). No significatives differences in intra-ballon pressure slope were observed between both groups. 79.2 per cent of NUD patients had chest pain with oesophageal ballon distension =<7 ml. vs. 5 per cent in controls (p>0.001). Mean volumes were 7.03 ml. (NUD) and 11.9 per cent (controls) (p=0.001). 63 per cent of dyspeptic patients with lowered gastric sensitivity tresholds (< 700 ml) had oesophagic symptoms with inflation volumes =< 7 ml. There was a positive correlation is stomach and oesophageal mechano sensiticities variations (r= 0.75 +/-0.58, p>0.01). Whem analyzed with that results, oesophageal acid perfusion test showed 38.5 per cent of "mixed sensitivities" (both mechano-and chemo-), 30.7 per cent of "mechano sensorials" (negative acid test, positive ballon test), and 10.3 per cent of schemo sensorials" (positive acid test only). In 20.5 per cent both tests were normal at the moment they were done. These results agreed with our previous experiences in oesophagus. Conclusions: It was concluded that a significative proportion of NUD patients had lowered tresholds for mechano stimulation of stomach and oesophagus at the time that both tests were done. Such alterations support the hypothesis that a more general mechano-sensitivity alteration in present in patients with NUD. (AU)

Electrogastrografia y vaciamento gastrico en pacientes con dispepsia no organica / Electrogastrography and gastric emptyng in non organic dispesia

La Electrogastrografía (EGG) permite establecer la frecuencia dominante del Ritmo Eléctrico B sico (REB) del estómago. El objetivo fue investigar la EGG en un grupo de pacientes con dispepsia no org nica (DNO). Se estudiaron 18 pacientes control (9 hombres y 9 mujeres, edad X 46.4 años, SEM 3.72, rango 24-72) y 52 con DNO (18 hombres y 34 mujeres, edad X 54.19 años, SEM 2.38, rango 17-86). Se utilizaron 2 electrodos de superficie Ag-CI2Ag en epigastrio y una referencia. An lisis de la señal con FFT. Sólo se tuvo en cuenta la frecuencia predominante en cada bloque y el por ciento total de tiempo de las frecuencias anormales (<2 y >4 cpm). Registro en ayunas por 30 minutos, y otros 30 minutos luego de la ingesta de 250 Cal. En 43 pacientes no sleccionados se estudió el tiempo de vaciamiento g strico por gammografía, con comida mixta marcada en la fase sólida con 99Tc. RESULTADOS: el X del REB en los controles fue de 2.99 cpm. En el 22 por ciento se observaron episodios aislados de frecuencias >4 cpm, pero < de 6 cpm, y nunca mayores del 8 por ciento del tiempo de registro. En los DNO el promedio en ayunas fue de 3.34 cpm (DS 0.67, p= 0.001). EN el 76.47 por ciento se observaron arritmias: 71.15 por ciento taquigastrias puras, 4.76 por ciento de bradigastrias puras, y 19.26 por ciento de alteraciones "mixtas". 48 por ciento de las taquigastrias se encontraron en el rango entre 30-60 por ciento del tiempo de registro. En el 96.1 por ciento de los pacientes con retardos en el vaciamiento g strico se observó E.G.G. anormal, Vs el 50 por ciento de los casos con vaciamiento en límites normales. No se encontraron diferencias significativas en la incidencia de arritmias g stricas entre los 3 grupos clínicos propuestos de dispepsia (tipos "ulcera", "dismotilidad" e "inespecíficos"). CONCLUSIONES: a) en m s de 76 por ciento de las DNO se observaron anormalidades en el REB m s all de los observado en los controles; b) predominio franco de taquigastrias; c) los casos clínicos m s severos se observaron en las bradisgastrias; d) no fue posible encontrar un asociación entre los síntomas y las alteraciones en el vaciamiento g strico; e)Las alteraciones del E.G.G. se asociaron en el 96 por ciento con las anormalidades en el vaciamiento g strico; f) no fue posible establecer una asociación entre los tipos clínicos propuestos de dispepsia y las alteraciones en el vaciamiento g strico y/o las anormalidades del E.G.G. (AU)

Comparación de la mecanosensibilidad gástrica en pacientes con dispepsia funcional (D.F.) / Comparison between gastric and esophageal mechano-sensitivity in patients with functional dyspepsia

Patients with non ulcer dyspepsia (NUD) and lowered mechano sensitivity tresholds in stomach may have lowered mechano sensitivity treholds in oesophagus also. The aim was to check this hypothesis. Methods: 39 patients with NUD (11 men and 24 women, mean age 57 years, SEM 3.72, range 17-86) and 20 controls (10 men, 10 women, mean age 49.3 years, SEM 3.72, range (31-66) were studied. Organis diseases were discarded. Gastric mechano sensitivity was studied with a latex ballon of low compliance, 8 cm lenght, conected to a manometer. Ballon was inflated "in ramp"at 10 ml/sec. and "first sensation", disconfort", and "pain" were registered. At 900 ml inflation was stopped if pain was not evoked. Oesophageal mechano sensitivity was studied with another latex ballon of low compliance which, after inflated with 15 ml. of air, was 3.5 cm. in diameter. Esophageal ballon was inflated "in ramp" (1 ml/sec) up 15 ml. and deflated in 2 cm step from 36 to 22 cm from SDA. Infaltion was stopped whrn symptoms (pain or disconfort were evoked. Oesophageal acid perfusion test was performed. Results: 83.4 per cent of controls completed up 700 ml. of gastric distension vs. 35.9 per cent of patients with NUD (p>0.001). No significatives differences in intra-ballon pressure slope were observed between both groups. 79.2 per cent of NUD patients had chest pain with oesophageal ballon distension =<7 ml. vs. 5 per cent in controls (p>0.001). Mean volumes were 7.03 ml. (NUD) and 11.9 per cent (controls) (p=0.001). 63 per cent of dyspeptic patients with lowered gastric sensitivity tresholds (< 700 ml) had oesophagic symptoms with inflation volumes =< 7 ml. There was a positive correlation is stomach and oesophageal mechano sensiticities variations (r= 0.75 +/-0.58, p>0.01). Whem analyzed with that results, oesophageal acid perfusion test showed 38.5 per cent of "mixed sensitivities" (both mechano-and chemo-), 30.7 per cent of "mechano sensorials" (negative acid test, positive ballon test), and 10.3 per cent of schemo sensorials" (positive acid test only). In 20.5 per cent both tests were normal at the moment they were done. These results agreed with our previous experiences in oesophagus. Conclusions: It was concluded that a significative proportion of NUD patients had lowered tresholds for mechano stimulation of stomach and oesophagus at the time that both tests were done. Such alterations support the hypothesis that a more general mechano-sensitivity alteration in present in patients with NUD.

Electrogastrografia y vaciamento gastrico en pacientes con dispepsia no organica / Electrogastrography and gastric emptyng in non organic dispesia

La Electrogastrografía (EGG) permite establecer la frecuencia dominante del Ritmo Eléctrico B sico (REB) del estómago. El objetivo fue investigar la EGG en un grupo de pacientes con dispepsia no org nica (DNO). Se estudiaron 18 pacientes control (9 hombres y 9 mujeres, edad X 46.4 años, SEM 3.72, rango 24-72) y 52 con DNO (18 hombres y 34 mujeres, edad X 54.19 años, SEM 2.38, rango 17-86). Se utilizaron 2 electrodos de superficie Ag-CI2Ag en epigastrio y una referencia. An lisis de la señal con FFT. Sólo se tuvo en cuenta la frecuencia predominante en cada bloque y el por ciento total de tiempo de las frecuencias anormales (<2 y >4 cpm). Registro en ayunas por 30 minutos, y otros 30 minutos luego de la ingesta de 250 Cal. En 43 pacientes no sleccionados se estudió el tiempo de vaciamiento g strico por gammografía, con comida mixta marcada en la fase sólida con 99Tc. RESULTADOS: el X del REB en los controles fue de 2.99 cpm. En el 22 por ciento se observaron episodios aislados de frecuencias >4 cpm, pero < de 6 cpm, y nunca mayores del 8 por ciento del tiempo de registro. En los DNO el promedio en ayunas fue de 3.34 cpm (DS 0.67, p= 0.001). EN el 76.47 por ciento se observaron arritmias: 71.15 por ciento taquigastrias puras, 4.76 por ciento de bradigastrias puras, y 19.26 por ciento de alteraciones "mixtas". 48 por ciento de las taquigastrias se encontraron en el rango entre 30-60 por ciento del tiempo de registro. En el 96.1 por ciento de los pacientes con retardos en el vaciamiento g strico se observó E.G.G. anormal, Vs el 50 por ciento de los casos con vaciamiento en límites normales. No se encontraron diferencias significativas en la incidencia de arritmias g stricas entre los 3 grupos clínicos propuestos de dispepsia (tipos "ulcera", "dismotilidad" e "inespecíficos"). CONCLUSIONES: a) en m s de 76 por ciento de las DNO se observaron anormalidades en el REB m s all de los observado en los controles; b) predominio franco de taquigastrias; c) los casos clínicos m s severos se observaron en las bradisgastrias; d) no fue posible encontrar un asociación entre los síntomas y las alteraciones en el vaciamiento g strico; e)Las alteraciones del E.G.G. se asociaron en el 96 por ciento con las anormalidades en el vaciamiento g strico; f) no fue posible establecer una asociación entre los tipos clínicos propuestos de dispepsia y las alteraciones en el vaciamiento g strico y/o las anormalidades del E.G.G.