Assuntos
Anticorpos Monoclonais/uso terapêutico , Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Metformina/uso terapêutico , Anticorpos Monoclonais Humanizados , Neoplasias da Mama/genética , Ensaios Clínicos Fase II como Assunto , Feminino , Humanos , Itália , Terapia Neoadjuvante , Ensaios Clínicos Controlados Aleatórios como Assunto , Receptor ErbB-2/biossíntese , Receptor ErbB-2/genética , Pesquisa Translacional Biomédica , TrastuzumabAssuntos
Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Carcinoma/metabolismo , Carcinoma/patologia , Células-Tronco Neoplásicas/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/genética , Carcinoma/diagnóstico , Carcinoma/genética , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Metástase Linfática , Metástase Neoplásica , Inoculação de Neoplasia , Células-Tronco Neoplásicas/metabolismoRESUMO
OBJECTIVE: To report an additional case of collecting duct carcinoma of the kidney, known as carcinoma of Bellini. METHODS/RESULTS: A 65-year-old male patient was admitted for left renal pain. An ultrasound scan showed a solid right renal mass. The patient underwent extended radical nephrectomy. Pathological analysis of the surgical specimen disclosed carcinoma of Bellini. The patient is asymptomatic 18 months postoperatively. CONCLUSIONS: Carcinoma of Bellini is an uncommon tumor type arising from the collecting duct cells and accounts for 0.5%-2% of all renal tumors.
Assuntos
Carcinoma de Células Renais/patologia , Neoplasias Renais/patologia , Túbulos Renais , Idoso , Humanos , MasculinoRESUMO
Report of one case of pure yolk sack testicular tumour in an adult patient. This was a stage I case which had been under observation for 3 years without further evidence of disease. Several aspects related with this type of germinal, non-seminomatous tumour of the testicle are commented upon.
Assuntos
Tumor do Seio Endodérmico , Neoplasias Testiculares , Adulto , Tumor do Seio Endodérmico/patologia , Humanos , Masculino , Neoplasias Testiculares/patologiaRESUMO
The role of systemic lupus erythematosus (SLE) in the development of acute pancreatitis is a matter of controversy since, in many cases, this complication has been attributed to the drugs administered. In this study, we present a patient diagnosed as having SLE who developed acute pancreatitis with no apparent cause aside from her basic disease, and in whose necropsy was observed vascular damage consisting of severe intimal proliferation. Pancreatic vascular lesions in previously reported patients with lupus are reviewed.
Assuntos
Lúpus Eritematoso Sistêmico/complicações , Pancreatite/etiologia , Doença Aguda , Adulto , Artérias/patologia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/patologia , Pâncreas/irrigação sanguínea , Pâncreas/patologia , Pancreatite/patologiaRESUMO
A 44-year-old male was diagnosed in August 1980 as having a retroperitoneal germ cell tumor (classic seminoma with anaplastic areas). After treatment with cisplatin-based chemotherapy, he reached complete clinical and pathological remission. Eighty-eight months later, in December 1987, he was diagnosed as having a testicular mixed germ cell tumor (embryonal carcinoma with anaplastic seminoma areas) after right orchiectomy. The potential mechanisms by which the latter tumor could have developed are discussed.
