RESUMO
Alpha-methylacyl-CoA racemase (AMACR) expression has been demonstrated in several normal tissues and in diverse types of carcinoma. Our aim was to analyze the immunohistochemical expression of AMACR in the sequence-progression of colonic cancer. We studied 237 cases, including samples of normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. A scale of intensity and percentage of expression was used to analyze the AMACR immunohistochemical profile. The expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases.
Assuntos
Adenocarcinoma/enzimologia , Proteínas de Neoplasias/análise , Racemases e Epimerases/análise , Adenoma/enzimologia , Idoso , Idoso de 80 Anos ou mais , Colo/enzimologia , Pólipos do Colo/enzimologia , Progressão da Doença , Feminino , Humanos , Mucosa Intestinal/enzimologia , Neoplasias Hepáticas/enzimologia , Neoplasias Hepáticas/secundário , Masculino , Pessoa de Meia-Idade , Estudos de AmostragemRESUMO
La expresión inmunohistoquímica de la alfa-metilacil-CoA racemasa (AMACR) ha sido demostrada en varios tejidos normales y en diferentes tipos de carcinomas. Nuestro objetivo fue analizar la expresión inmunohistoquímica de la AMACR en la secuencia-progresión del carcinoma de colon. Se estudiaron 237 casos, que incluían muestras de mucosa colónica normal, adenomas con distintos grados de displasia, carcinomas de colon, y metástasis ganglionares y hepáticas de carcinoma colónico. Para el análisis de la expresión inmunohistoquímica de la AMACR se utilizó una escala que valoraba la intensidad y el porcentaje de su expresión en el tejido. La expresión fue casi nula en las muestras de mucosa normal, se incrementó en los adenomas y carcinomas, disminuyó de forma significativa en las metástasis ganglionares, pero volvió a aumentar su expresión en las metástasis hepáticas (AU)
Alpha-methylacyl-CoA racemase (AMACR) expression has been demonstrated in several normal tissues and in diverse types of carcinoma. Our aim was to analyze the immunohistochemical expression of AMACR in the sequence-progression of colonic cancer. We studied 237 cases, including samples of normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. A scale of intensity and percentage of expression was used to analyze the AMACR immunohistochemical profile. The expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases (AU)
