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1.
Acta Vet Scand ; 60(1): 30, 2018 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-29784055

RESUMO

BACKGROUND: Cranial cruciate ligament rupture is a prevalent injury in dogs, and tibial plateau leveling osteotomy (TPLO) is one of the preferred surgical techniques. Surgical site infection is a possible complication following TPLO and measurement of serum acute phase proteins is suggested to be a way to early recognize and distinguish postoperative infectious complications from normal postoperative inflammatory conditions. In this study we investigate the changes in concentrations of the systemic inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) following tibial plateau leveling osteotomy (TPLO) in dogs and evaluate if deviations from the changes expectedly induced by the surgical procedure are useful in early detection of post-surgical infections. Dogs with cranial cruciate ligament injuries treated by TPLO at the Region Animal Hospital of Helsingborg during 2012 were included. Dogs with concurrent diseases, other orthopedic problems, or noninfectious post-surgical complications were excluded. Serial measurements of CRP and SAA concentrations were made. Changes in concentrations were visualized graphically and the discriminative capacity to detect infectious post-surgical complications was tested at different time points. RESULTS: A characteristic pattern of changes in concentrations of CRP and SAA were observed following TPLO with a significant increase 24 h post-surgery in all dogs and baseline-concentrations re-established at day 12. In dogs that developed post-surgical infections, a deviation in form of significantly higher concentrations of CRP and SAA were observed at day 6, compared to un-complicated cases. High-discriminative clinical decision limits of CRP (43.9 mg/L) and SAA (63.8 mg/L) could be established for differentiation of dogs with and without clinical signs of infectious complications at day 6 post-operatively, applicable to reliably rule out presence of infectious complications due to very high sensitivity (no false negatives). CONCLUSIONS: The CRP and SAA levels in dogs with clinical signs of post-surgical infectious complication deviated from the typical levels expected at day 6 after surgery, and clinical decision limits to reliably rule out presence of infectious complications was suggested.


Assuntos
Proteína C-Reativa/metabolismo , Cães/cirurgia , Osteotomia/efeitos adversos , Complicações Pós-Operatórias/veterinária , Proteína Amiloide A Sérica/metabolismo , Animais , Lesões do Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/veterinária , Estudos Longitudinais , Complicações Pós-Operatórias/sangue , Estudos Prospectivos
2.
Acta Vet Scand ; 54: 18, 2012 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-22452858

RESUMO

Infection with Brucella canis has been diagnosed in Sweden for the first time. It was diagnosed in a three-year-old breeding bitch with reproductive disturbances. Fifteen in-contact dogs were tested repeatedly and all of them were negative for B. canis. The source of infection could not be defined. The present article describes the case and the measures undertaken and gives a short review over B. canis. Recommendations on how to avoid the infection in non-endemic countries are given.


Assuntos
Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Brucella canis/isolamento & purificação , Brucelose/prevenção & controle , Brucelose/veterinária , Doenças do Cão/diagnóstico , Ergolinas/uso terapêutico , Animais , Brucelose/diagnóstico , Brucelose/tratamento farmacológico , Cabergolina , Busca de Comunicante/veterinária , Doenças do Cão/tratamento farmacológico , Doenças do Cão/prevenção & controle , Doenças do Cão/transmissão , Cães , Feminino , Humanos , Guias de Prática Clínica como Assunto , Suécia/epidemiologia
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