[Dynamic Changes of Fast Spin-echo T 2 Weighted Images Displayed Topical Reactions to Micro-invasive Catgut-embedment of Zusanli (ST 36) in Healthy Volunteer Subjects].

OBJECTIVE: To observe the duration of local reactions after subcutaneous micro-invasive catgut-embedding stimulation in Zusanli(ST 36) region in normal human body by using magnetic resonance (MR) T 2-mapping, so as to find a reasonable interval between every two catgut-embedding performance. METHODS: A total of 8 normal volunteers (3 women, and 5 men) were enrolled in the present study. Before and 8 h, and 3, 7, 14, 21, 28 and 35 days after the subcutaneous micro-invasive embedment of catgut (Gauge 2.0, 2 cm long) in the left Zusanli (ST 36) area, the local T 2-weighted images (T 2 WI) and fat-suppression T 2-weighted images (FS T 2 WI) were detected and recorded by using MR scan (GE Optima MR 360 1.5 T) and analyzed using FuncTool software. RESULTS: Compared with pre-catgut-embedment, the local signal strength of T 2 FS WI and T 2 relaxation time began to rise on the 8th hour after catgut-embedment, peaked on the 3rd day, began to descend on the 7th day, but being still higher than pre-embedment, and turned to the normal level on the 21st day to the 35th day. Results of statistical analysis displayed that compared with pre-catgut-embedment, T 2 relaxation time levels were significantly higher on the 8th h, day 3, 7 and 14 after the embedment (P<0.01), and were comparable to that of pre-embedment on day 21, 28 and 35 (P>0.05). CONCLUSIONS: Catgut-embedment of Zusanli (ST 36) induces an apparent change of MRI signals from the 8th h to the 14th day in normal volunteer subjects, suggesting that an interval of 21 days may be reasonable for the micro-invasion catgut-embedment in clinical practice.

[Effects of ear point needle embedding therapy on memory disorder and expression of beta-amyloid protein in the rat of vascular dementia].

OBJECTIVE: To study the mechanism of auricular acupuncture for improvement of learning and memory disorders in the rat of vascular dementia (VD). METHODS: The vascular dementia rat model was made by 4-vessel occlusion method. Four groups, a sham operation group, a normal control group, a model group and an auricular acupuncture group were set up. After acupuncture was given at auricular points, Brain and Kidney. Immunohistochemical analysis, behavioural observation and computer image analysis were made. RESULTS: Auricular acupuncture could decrease significantly the beta-amyloid protein (A beta) immunoreactivive neurons and increase its average optical density in the parietal cortex of the VD rats (P < 0.05). CONCLUSION: Auricular acupuncture can reduce or inhibit the over-production of Abeta in the brain, so as to improve the learning and memory capacity of the VD model rat.

[Effects of acupoint thread implantation and Chinese herb on PTH and TGF-beta1 in the rate of chronic renal failure].

OBJECTIVE: To probe into the mechanisms of thread implantation at Zusanli(ST 36) and Chinese herbs in treatment of chronic renal failure(CRF). METHODS: CRF rat model was made by Platt subtotal nephrectomy. They were divided into 5 groups, sham operation group, model group, Chinese herbs group, thread implantation group and thread implantation plus Chinese herbs group. After treatment of 8 weeks, serum parathyroid hormone (PHT), transforming growth factor beta1 (TGF-beta1) expression in residual renal cells, malondialdehyde(MDA) content in the residual renal tissue, serum urea nitrogen(BUN) and creatinine(Scr), protein in urine and pathological changes were investigated. RESULTS: The above indexes after treatment by thread implantation at acupoint, Chinese herbs, and acupoint thread implantation plus Chinese herbs showed begin reversion, especially, the most obviously improvement in the acupoint thread implantation plus Chinese herbs treatment group. CONCLUSION: The mechanism of acupoint thread implantation and Chinese herbs in improvement of CRF is related with decrease of PTH, inhibition of TGF-beta1 expression, decrease of MDA content and resisting lesion of renal fibrosis.