RESUMO
BACKGROUND: The clinical and financial impact of surgical site infection after ventral hernia repair is significant. Here we investigate the impact of dual antibiotic irrigation on SSI after VHR. METHODS: This was a multicenter, prospective randomized control trial of open retromuscular VHR with mesh. Patients were randomized to gentamicin â+ âclindamycin (G â+ âC) (n â= â125) vs saline (n â= â125) irrigation at time of mesh placement. Primary outcome was 30-day SSI. RESULTS: No significant difference was seen in SSI between control and antibiotic irrigation (9.91 vs 9.09 â%; p â= â0.836). No differences were seen in secondary outcomes: SSO (11.71 vs 13.64 â%; p â= â0.667); 90-day SSO (11.1 vs 13.9 â%; p â= â0.603); 90-day SSI (6.9 vs 3.8 â%; p â= â0.389); SSIPI (7.21 vs 7.27 â%, p â= â0.985); SSOPI (3.6 vs 3.64 â%; p â= â0.990); 30-day readmission (9.91 vs 6.36 â%; p â= â0.335); reoperation (5.41 vs 0.91 â%; p â= â0.056). CONCLUSION: Dual antibiotic irrigation with G â+ âC did not reduce the risk of surgical site infection during open retromuscular ventral hernia repair.
Assuntos
Antibacterianos , Gentamicinas , Hérnia Ventral , Herniorrafia , Infecção da Ferida Cirúrgica , Irrigação Terapêutica , Humanos , Hérnia Ventral/cirurgia , Infecção da Ferida Cirúrgica/prevenção & controle , Infecção da Ferida Cirúrgica/epidemiologia , Masculino , Feminino , Pessoa de Meia-Idade , Estudos Prospectivos , Herniorrafia/efeitos adversos , Antibacterianos/uso terapêutico , Antibacterianos/administração & dosagem , Gentamicinas/administração & dosagem , Gentamicinas/uso terapêutico , Incidência , Irrigação Terapêutica/métodos , Clindamicina/uso terapêutico , Clindamicina/administração & dosagem , Idoso , Telas Cirúrgicas , Resultado do Tratamento , AdultoRESUMO
INTRODUCTION: The most appropriate method of reconstructing the abdominal wall at the site of a simultaneous stoma takedown is controversial. The contaminated field, concomitant GI procedure being performed and presence of a hernia all complicate decision-making. We sought to describe the surgical approaches, mesh type and outcomes of concomitant abdominal wall reconstruction during stoma takedown in a large hernia registry. METHODS AND PROCEDURES: All patients who underwent stoma takedown with simultaneous hernia repair with retromuscular mesh placement from January 2014 to May 2022 were identified within the Abdominal Core Health Quality Collaborative (ACHQC). Patients were stratified by mesh type including permanent synthetic (PS), resorbable synthetic (RS) and biologic mesh. Association of mesh type with 30-day wound events and other complications and 1-year outcomes were evaluated. RESULTS: There were 368 patients who met inclusion criteria. Eighty-nine patients had ileostomies, 276 colostomies and 3 had both. Two hundred and seventy-nine (75.8%) patients received PS mesh, 46 (12.5%) biologic, and 43 (11.7%) RS. Seventy percent (259/368) had a parastomal hernia, 75% (285/368) had a midline incisional hernia, and 48% (178/368) had both. All groups had similar preoperative comorbidities and the majority had a transversus abdominus release. All mesh groups had similar thirty-day SSI (13.2-14.3%), SSO (10.5-17.8%) and SSOPI (7.9-14.1%), p = 0.6. Three patients with PS mesh developed infected synthetic mesh and one PS mesh required excision. Four patients with PS developed an enterocutaneous fistula. Of these, only one patient was recorded as having both an enterocutaneous fistula and mesh infection. Thirty-day reoperation and readmission were similar across all mesh groups. Recurrence at 1-year was similar between mesh groups. Quality of life measured using HerQLes scores were higher at one year compared to baseline in all groups indicating improvement in hernia-specific quality of life. CONCLUSION: Early complication rates associated with simultaneous stoma takedown and abdominal wall reconstruction are significant, regardless of mesh type utilized. Concomitant surgery should be weighed heavily and tailored to individual patients.
