A European survey on biobanks: trends and issues.

Biobanks have recently gained great significance for research and personalised medicine, being recognised as a crucial infrastructure. At the same time, the widely varied practices in biobanking may also pose a barrier to cross-border research and collaboration by limiting access to samples and data. Nevertheless, the extent of the actual activities and the impact of the level of networking and harmonisation have not been fully assessed. To address these issues and to obtain missing knowledge on the extent of biobanking in Europe, the Institute for Prospective Technological Studies (IPTS) of the European Commission's Joint Research Centre, in collaboration with the European Science and Technology Observatory (ESTO), conducted a survey among European biobanks. In total, 126 biobanks from 23 countries responded to the survey. Most of them are small or medium-sized public collections set up either for population-based or disease-specific research purposes. The survey indicated a limited networking among the infrastructures. The large majority of them are stand-alone collections and only about half indicated to have a policy for cross-border sharing of samples. Yet, scientific collaborations based on the use of each biobank appear to be prominent. Significant variability was found in terms of consent requirements and related procedures as well as for privacy and data protection issues among the biobanks surveyed. To help promote networking of biobanks and thus maximise public health benefits, at least some degree of harmonisation should be achieved.

Cranio-facial morphology in children with and without enlarged tonsils.

The purpose of the present study was to compare the cranio-facial morphology in children with and without enlarged tonsils. The material consisted of 73 children with enlarged tonsils, and a control group of children with normal tonsils, matched for age, sex, and number. The mean age for the groups was 10.1 and 10.0 years, respectively. Evaluation of anamnestic history, clinical examination, and lateral skull radiographs were undertaken. Compared to the control children, the children with enlarged tonsils had more retrognathic and posteriorly inclined mandibles, larger anterior total and lower facial heights, and larger mandibular plane angles. Regression analyses revealed that functional, postural, and morphological factors, such as open mouth posture, low posture of the tongue, large depth of oropharynx at the site of the tonsils as well as mouth-breathing at night, were associated with skeletal features expressing an increased open vertical configuration and mandibular retrognathism.

Dentition in children with enlarged tonsils compared to control children.

The aim of the present study was to evaluate whether or not there are any differences in the dentition between children with enlarged tonsils and those with normal tonsils. A sample of 73 children (33 boys and 40 girls) with enlarged tonsils and with a mean age of 10.1 years was compared with a normal control group, matched for age and sex. Eighteen dentition variables and thirty-two variables in anamnestic, clinical, pharyngeal and postural findings were recorded. Measurements were obtained from lateral skull radiographs and dental casts. Group means were compared. Relationships between variables were studied using simple correlations and multiple stepwise regression analyses. It was found that children with enlarged tonsils had more retroclined lower incisors, more anteriorly positioned upper incisors, smaller overbite, larger overjet, shorter lower dental arches, narrower upper dental arches and an increased frequency of lateral crossbite. Functional and/or morphological disorders, causing an open posture of the mouth, a lowered anterior posture of the tongue and a low position of the hyoid bone are thought to be associated with the differences in the dentition between the two groups. Obstruction of the oropharynx by enlarged tonsils, might be one factor responsible for these dysfunctions.