Stimulation of dendrogenesis and neural maturation in adult mammals.

This work is the result of a technical research patent on dendritogenesis and neuronal maturation, in which the existence was determined of patent documents involving the use of melatonin for the treatment of anxiety, obesity and related diseases of the peripheral and CNS. In this study, an analysis of the state of the art in order to collect technical and scientific elements for the drafting of a new patent on the use of the melatonin molecule in stimulating neuronal maturation in dendritogenesis and mammals was conducted in adults. This study is based on an invention related with this novel use of melatonin.

Olfactory neuroepithelium as a cellular model for the diagnosis of neuropsychiatric diseases.

The neuroepithelium has been used as an experimental model to find biological markers for neuropsychiatric disease diagnosis. Patent information permits understanding of the state of the art of neuroepithelium in neuropsychiatric disease diagnosis, as well as the identification of trends in research and development on this theme. In this article, we discuss diverse methods for obtaining primary cultures of olfactory neurons obtained by animal dissection or by postmortem biopsy of human cadavers. The principal owners of patents related to olfactory neuroepithelia are universities such as John Hopkins and Bristol-Myers Squibb. The USA has the most research lines and approved patents in the world, while Rutgers, the State University of New Jersey, provides composition and methods related to the diagnoses and treatment of neuropsychiatric disorders.