Glyphosate Toxicity: In Vivo, In Vitro, and Epidemiological Evidence.

Glyphosate is the most applied agricultural chemical worldwide and has become nearly ubiquitous throughout the environment. Glyphosate is an effective herbicide because it disrupts the shikimate pathway, which is responsible for the synthesis of essential amino acids in plants and microorganisms. Given that there is no known target for glyphosate in higher animals, its toxicity to humans and other animals is heavily debated, especially after the 2015 IARC ruling that glyphosate is carcinogenic. Today, a growing body of literature shows in vitro, in vivo, and epidemiological evidence for the toxicity of glyphosate across animal species. With the application of glyphosate increasing globally, it is important to discuss these reports to enable a broader conversation on glyphosate toxicity and its impact on human and environmental health. Here, we summarize the recent glyphosate literature and discuss its implications.

Utilizing additive manufacturing and mass customization under capacity constraints.

Additive manufacturing (AM), originally used for prototyping, is increasingly adopted for custom final part production across different industries. However, printing speed and production volume are two barriers for the adoption of AM for product customization at large scale. Nevertheless, manufacturers could aim to combine the benefits of AM for product customization with traditional mass customization (MC) technologies over the product life cycle (PLC). This approach is showcased in our paper as a manufacturing opportunity and is addressed via a non convex-concave optimization model that considers a monopolist manufacturer producing horizontally differentiated products at scale. To satisfy individual customer preferences under capacity considerations, the firm jointly decides on the inventory, production quantity, product variety, optimal technology-switching times (between AM and MC) and pricing strategy. Our approach can be implemented by decision-makers to leverage customer-centricity and benefit from this novel hybrid manufacturing practice. By deriving a closed-form solution for the production quantity based on an adaptive inventory policy, the resulting optimization problem is solved using the Sample Average Approximation framework grounded by analytical results. Our results demonstrate that the new usage of AM with MC can benefit a manufacturer for customer-centric driven strategies. Significant profit improvements can be achieved with an AM-MC-AM technology-switching scenario under certain capacity conditions and with an increasing-decreasing pricing strategy. Our results also indicate that the benefits of pricing flexibility are highest when capacity is unlimited or when the firm does not hold inventory. Under capacity constraints, a simple decreasing pricing policy combined with inventory performs very well.

Digest: The contribution of historical climate events in shaping the modern latitudinal diversity gradient of ancient reptiles.

It is recognized that biodiversity changes across the planet latitudinally; however, the timing of and reasons for diversity loss at higher latitudes are not well understood. Meseguer and Condamine investigate phylogenies and fossil evidence of reptilian species and determine that global warming and cooling events allowed asymmetric extinction and dispersion across latitudes, suggesting a hypothesis where climate profoundly shapes the latitudinal diversity gradient in certain taxa.