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1.
Am J Transl Res ; 14(5): 3113-3120, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35702108

RESUMO

OBJECTIVE: The purpose of this research was to observe the characteristics of atherosclerosis in diabetic patients by ultrasound and analyze the factors influencing the development of atherosclerosis in these patients. METHODS: Ninety diabetic patients treated in our hospital from January 2019 to December 2019 were enrolled in this retrospective analysis. The transcranial Doppler ultrasound (TCD) and carotid ultrasound were used to determine the presence of intracranial (stenosis) and extracranial (plaque) atherosclerosis. The differences in characteristics of different lesions and risk factors for the development of atherosclerosis were compared. RESULTS: Ultrasound examination of the 90 enrolled patients showed that 5 (5.56%) had only intracranial artery stenosis, 30 (33.33%) had only extracranial atherosclerosis, 20 (22.22%) had intracranial artery stenosis combined with extracranial atherosclerosis, and 35 (38.89%) had no lesions. The intracranial stenosis rate (27.78%) was significantly higher than that of extracranial carotid stenosis or occlusion (2.22%) (P < 0.001). Logistic regression analysis revealed that the duration of diabetes mellitus and concomitant hypertension were independent risk factors for intracranial and extracranial atherosclerosis (P < 0.05). Compared with the control group, the study group showed reduced carotid plaque, decreased inflammatory response, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) as well as elevated high-density lipoprotein cholesterol (HDL-C) (P < 0.05). CONCLUSION: Diabetic patients have a higher incidence of atherosclerosis, which is related to the duration of the diabetes mellitus and concomitant hypertension, so the monitoring of these patients needs to be strengthened. In addition, the administration of atorvastatin can better improve hyperlipidemia and slow down the development of atherosclerosis.

2.
Am J Transl Res ; 13(5): 5200-5207, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34150109

RESUMO

OBJECTIVE: To investigate the clinical application values of electrocardiogram (ECG) combined with ultrasound cardiogram (UCG) in the differential diagnosis of cardiomyopathy. METHODS: A total of 120 patients with cardiomyopathy who were admitted to our hospital were randomly divided into the dilated cardiomyopathy (DCM) group (60 cases) and the ischemic cardiomyopathy (ICM) group (60 cases). Both groups were examined using ECG combined with UCG. The ultrasonic values (aorta, LADI, LVDd, LVESD, RVID, SV, LVEF, LVET, EPSS, E/A, RV6, RV6/RMAX), morphological changes (thin and round left ventricular apex, spherical left ventricle, arch-shaped left ventricle, segmental wall-motion abnormalities (SWMAs), diffuse wall motion abnormalities (DWMAs), paradoxical ventricular wall motion) and heart valve regurgitation (aortic valve, mitral valve, tricuspid valve, pulmonary valve) were compared and analyzed. RESULTS: The degree of chamber enlargement in the DCM group was remarkably higher than that in the ICM group, but the degree of LVEF and aortic enlargement were significantly lower than those in the ICM group (P<0.05). The detection rates of spherical left ventricle and DWMAs in the DCM group were 60.00% and 100.00% respectively, which was significantly higher than those (6.66% and 40.00%) of the ICM group (P<0.05), but the detection rates of thin and round left ventricular apex, arch-shaped left ventricle, SWMAs, and paradoxical ventricular wall motion were 53.33%, 66.66%, 46.66% and 20.00% respectively in the ICM group, which were markedly higher than those in the DCM group. The incidence rates of aortic valve, mitral valve, tricuspid valve and pulmonary valve in the DCM group were 66.66%, 100.00%, 46.66% and 76.66%, which were notably higher than those (36.66%, 93.33%, 26.66% and 40.00%) in the ICM group (P<0.05). CONCLUSION: ECG combined with UCG examination can effectively improve the judgment rate and diagnosis accuracy of cardiomyopathy. Due to its high safety, ECG combined with UCG examination is worthy of clinical promotion and application.

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