[The significance of the central regulation of sexual behavior in experimental alcoholism in male white rats]. / O znachenii tsentral'noi reguliatsii polovogo povedeniia pri éksperimental'nom alkogolizme samtsov belykh krys.

It has been shown that ethanol consumption by rats with a decreased activity of the brain zones, which regulate sexual behavior, declines but alcoholic motivation increases on destruction of the brain zones responsible for feeding behavior.

[Effect of testosterone on ethanol oxidation during chronic alcoholism in castrated rats]. / Vliianie testosterona na okislenie étanola pri khronicheskom alkogolizme u kastrirovannykh krys.

It has been shown in non-alcoholized male rats that castration significantly and appreciably raises the level of endogenous ethanol. In chronic alcoholization of castrated and non-castrated rats, the rate of ethanol elimination (REE) is noticeably increased, with testosterone producing no essential effect on the REE. In the liver, alcohol dehydrogenase activity rises insignificantly under the effect of testosterone, whereas aldehyde dehydrogenase activity declines 30--100%.

[Effect of sex hormones on the cold resistance of rats in chronic alcohol intoxication]. / Vliianie polovykh gormonov na ustoichivost' k kholodu krys s khronicheskoi alkogol'noi intoksikatsiei.

Testosterone effect on the male rat resistance to the transitory moderate and prolonged acute action of cold was studied as compared with that of estrogens estradiol benzoate and progesterone in experiments on castrated animals with habitual alcohol dependence. It was shown that the resistance of the castrated made rats to the prolonged acute cold effect sharply decreases under estrogen action, whereas testosterone exerts a protective effect under the same conditions, enlarging the period of non-contagiosity to infections, produced by an excessive cooling.

[Adaptative effect of methyltestosterone on the protective behavior of male rats]. / Adaptivnoe vliianie metiltestosterona na zashchitnoe povedenie samtsov krys.

It was shown that male rats castrated one month before the experiment, were not able to pass into a dark cage from a light one, if the excitation, produced by the electrode floor between dark and light parts, was slightly higher than that of the pain threshold. Neither affiliation nor sexual desire change their passing ability. Methyltestosterone injections in doses of 25 mg/kg intraperitoneally 30 minutes before castration markedly enhance the capacity of the same male rats to realize the passage into a dark cage, owing to an almost double fall of the pain threshold and increased pain tolerance. Methyltestosterone affiliation and sexual desire stimulate the pain barrier overcoming at the moment of passing into a dark cage. Methyltestosterone analgesic activity was found to be 5 times more powerful when studied in the cage, allowing the passage into a dark cage, in contrast to the similar test performed under a bell glass. The results obtained illustrate an adaptive methyltestosterone role in the form studied in non-sexual specific protective behaviour.

[Role of the adrenolytic properties of neuroleptics in their effects on ethanol addiction]. / Znachenie adrenoliticheskikh svoistv neiroleptikov v ikh vliianii na pristrastie k étanolu.

It has been shown in castrated male white rats that testosterone exerts a prolonged selective stimulant effect on the course of experimental alcoholism. The experimental ethanol addiction was suppressed by psychotropic substances that decrease the androgenic status of the organism. It is assumed that the inhibitory effect of neuroleptics on ethanol addiction seen in these experiments is mediated by their adrenolytic rather than antidopaminergic properties.

The role of testosterone in the development of experimental alcoholism.

The hormonal effects of testosterone, progesterone and extradiol on voluntary preference of ethanol were investigated in experiments carried out on castrated male albino rats. It was observed that testosterone stimulated the development of ethanol preference, while the effects of progesterone and estradiol were significantly slower and less intensive. It was also observed that the androgenic action of testosterone was more important than its anabolic action in stimulating ethanol preference.