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Int J Tuberc Lung Dis ; 20(12): 1639-1646, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27931340

RESUMO

SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Gurin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT. RESULTS: For 81 of the 109 children, the final diagnosis was TB. The remaining 28 children did not have TB. QFT-GIT had a sensitivity of 66% (95%CI 5277) for the diagnosis of TB, and a specificity of 100% (95%CI 88100). The tuberculin skin test (TST) had lower sensitivity, at 46% (95%CI 3360), and its concordance with QFT-GIT was limited (69%). Combining QFT-GIT and TST results increased sensitivity to 83% (95%CI 6992). CONCLUSION: In epidemiological settings such as those found in Morocco, QFT-GIT is more sensitive than the TST for active TB diagnosis in children. Combining the TST and QFT-GIT would be useful for the diagnosis of active TB in children, in combination with clinical, radiological and laboratory data.


Assuntos
Testes de Liberação de Interferon-gama , Teste Tuberculínico , Tuberculose/diagnóstico , Tuberculose/epidemiologia , Adolescente , Vacina BCG/administração & dosagem , Criança , Pré-Escolar , Humanos , Incidência , Lactente , Marrocos/epidemiologia , Estudos Prospectivos , Sensibilidade e Especificidade , Tuberculose/prevenção & controle , Vacinação
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