1.
J Org Chem
; 76(16): 6503-17, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21657272
RESUMO
A thiourea/proline derivative-catalyzed synthesis of linear α-substituted tetrahydrofuran/pyran derivatives starting with lactol substrates is presented. This study demonstrates the utility and potential complications of using (thio)urea/proline cocatalysis as each of these catalysts is necessary to provide the observed reactivity, but a time-dependent decrease in enantioselectivity is observed. New mechanistic insights into (thio)urea/proline cocatalysis are presented.