Assuntos
Hemocromatose/diagnóstico por imagem , Artropatias/diagnóstico por imagem , Biópsia , Hemocromatose/complicações , Hemocromatose/patologia , Articulação do Quadril/diagnóstico por imagem , Humanos , Artropatias/etiologia , Artropatias/patologia , Articulação do Joelho/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Radiografia , Membrana Sinovial/patologia , Articulação do Punho/diagnóstico por imagemAssuntos
Hemartrose/etiologia , Hemofilia A/complicações , Articulação do Joelho/diagnóstico por imagem , Adulto , Doença Crônica , Hemartrose/diagnóstico por imagem , Hemartrose/patologia , Hemofilia A/diagnóstico , Hemofilia A/patologia , Humanos , Articulação do Joelho/patologia , Imageamento por Ressonância Magnética , Masculino , Radiografia , RecidivaAssuntos
Artrite Infecciosa/diagnóstico por imagem , Artrite Psoriásica/diagnóstico por imagem , Infecções por HIV/complicações , HIV-1 , Adulto , Artrite Infecciosa/etiologia , Artrite Infecciosa/virologia , Artrite Psoriásica/etiologia , Artrite Psoriásica/virologia , Doença Crônica , Progressão da Doença , Infecções por HIV/diagnóstico por imagem , Mãos/diagnóstico por imagem , Humanos , Masculino , RadiografiaRESUMO
OBJECTIVE: To evaluate the effect of concurrent ranitidine therapy on theophylline metabolism in healthy Koreans. DESIGN: A 4-week, double-blind, randomized, placebo-controlled, crossover study. SETTING: The Clinical Research Unit, Department of Pharmaceutical Sciences, Yanbian Medical College, Yanji, China. SUBJECTS: Six young, healthy, nonsmoking Korean volunteers residing in China with no known factors that would alter theophylline metabolism. INTERVENTIONS: Subjects received extended-release oral theophylline at a constant dosage over 4 weeks to yield a serum concentration (Cp) between 5 and 10 micrograms/mL. Week 1 was the dosage titration phase. During week 2 subjects randomly received either ranitidine or a matching placebo. Week 3 was a washout phase, and during week 4 subjects were crossed over to receive either placebo or ranitidine. At the end of each treatment week, serum and urinary metabolite concentrations were measured. OUTCOME MEASURES: Theophylline serum concentrations and urinary concentrations of 1-methylxanthine, 1-methyluric acid, 3-methylxanthine, and 1,3-dimethyluric acid were measured. Estimates of clearance (Cl), volume of distribution (Vd), and half-life (t1/2) were determined. RESULTS: Concurrent administration of ranitidine with theophylline did not significantly alter theophylline Cp, Cl, Vd, or t1/2. Urinary concentrations of major theophylline metabolites also were not changed. CONCLUSIONS: Ranitidine does not significantly alter the metabolism of theophylline in healthy Koreans residing in China.