RESUMO
The present article describes the chemical composition and biological activities of the essential oils of B. glabrifolia leaves obtained in four consecutive years (2015-2018). The essential oils contained α-terpineol (17.9-29.7 %), α-terpinene (12.6-17.4 %), limonene (14.9-26.8 %) and ß-pinene (2.1-16.7 %) as the most abundant volatiles. The essential oils and these volatiles showed a significant adulticide activity (p<0.01; LC50 <100â µg mL-1 ) on the maize weevil (Sitophilus zeamais) with a 100 % mortality rate within a period of 5â h. Also, the essential oils showed a strong antibacterial activity on Enterococcus faecalis ATCC 29212 (MIC, 132.7-173.6â µg mL-1 ) and Helicobacter pylori ATCC 43504 (MIC, 74.8-199.2â µg mL-1 ). The assessment of the main volatiles revealed α-terpineol as the principal antibacterial agent (MIC, 78.6-149.7â µg mL-1 ). Similarly, the essential oils exhibited a substantial inâ vitro antiproliferative activity on the human prostate cancer cell lines PC-3 (LC50 , 15.2-19.4â µg mL-1 ), the human ovarian carcinoma cell lines OVCAR-3 (LC50 , 27.3-53.7â µg mL-1 ) and the myelogenous leukemia cell lines K-562 (LC50 , 32.4-75.9â µg mL-1 ). α-Terpineol (LC50 , 32.4-75.9â µg mL-1 ) exhibited the strongest antiproliferative effect on these cancer cell lines (LC50 , 22.4-48.1â µg mL-1 ).
