Use of recombinant human granulocyte colony-stimulating factor prior to autologous bone marrow transplantation in dogs with lymphoma.

OBJECTIVE: To retrospectively assess the safety and efficacy of recombinant human granulocyte colony-stimulating factor (G-CSF) used as part of autologous bone marrow transplantation in dogs with lymphoma. ANIMALS: 21 dogs with lymphoma at any disease stage. PROCEDURES: Medical records of dogs with lymphoma that underwent intensified chemotherapy and received an autologous bone marrow transplant following owner administration of recombinant human G-CSF (5 µg/kg, SC, q 12 h) for 7 days between January 2007 and July 2009 were reviewed. Results of physical examinations and CBCs performed before and at intervals during a 24-month period after G-CSF treatment were assessed. The safety of recombinant human G-CSF administration was determined via assessment of both short-term (ie, during the 7-day G-CSF treatment period) and long-term adverse effects. RESULTS: None of the dogs developed any adverse effect attributable to the administration of recombinant human G-CSF during G-CSF administration or during follow-up periods of 1 month to 2 years (median follow-up period, 4 months). Among the 18 dogs for which CBC results were available for analysis, mean circulating neutrophil count significantly increased after administration of recombinant human G-CSF, compared with value before treatment. CONCLUSIONS AND CLINICAL RELEVANCE- Results indicated that recombinant human G-CSF administered SC at a dosage of 5 µg/kg every 12 hours for 7 days appeared to be safe and effective when used in dogs with lymphoma that were undergoing autologous bone marrow transplant.

Paraneoplastic hypercalcemia in a dog with thyroid carcinoma.

This case report describes a dog with thyroid carcinoma and paraneoplastic hypercalcemia. Following thyroidectomy the dog became hypocalcemic and required supplementation with calcitriol and calcium carbonate. During the following 2 years, attempts to reduce the supplementation resulted in hypocalcemia. The dog died from renal failure with no evidence of thyroid carcinoma.

Hypercalcémie paranéoplasique chez un chien atteint d'un carcinome thyroïdien. Ce rapport de cas décrit un chien atteint d'un carcinome thyroïdien et d'hypercalcémie paranéoplasique. Après une thyroïdectomie, le chien est devenu hypocalcémique et a nécessité une supplémentation au calcitriol et au carbonate de calcium. Durant les deux années suivantes, des tentatives de réduction de la supplémentation ont provoqué l'hypocalcémie. Le chien est mort d'insuffisance rénale sans signe de carcinome thyroïdien.(Traduit par Isabelle Vallières).