RESUMO
It is often difficult to determine the origin a pleural effusion even if it is very important for prognosis of a patient. We have studied No. 200 patients, affected with nontraumatic effusions, using cytogenetic technics and cytologic examination. Cytologic diagnosis of pleural effusions allows to detect correctly its malignant nature in a percentage of cases ranging, according to various Authors, between 45 and 80%. The main parameters we have considered in our study, in order to value chromosomal analysis as a useful test for malignity in pleural effusions, can be, at least, placed upon those obtained with cytologic diagnosis. Therefore, we think we can consider chromosomal analysis in neoplastic effusions as a useful completion in terms of diagnostic advantage of cytologic diagnosis.
Assuntos
Aberrações Cromossômicas , Transtornos Cromossômicos , Neoplasias/patologia , Derrame Pleural/patologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/genética , Derrame Pleural/genética , Valor Preditivo dos TestesRESUMO
Non-ketotic hyperosmolar diabetic coma is a complication of diabetes characterised by extreme dehydration, plasmatic hyperosmolarity and the absence of ketosis. The mortality rate is very high, especially in elderly subjects with type II diabetes. A personal series of 12 cases is reported with an assessment of general features, triggering factors, biochemical parameters at onset and treatment given. The data confirm reports in the literature and the results show the therapeutic superiority of continuous endovenous infusions of insulin at 3-10 mu/hour over other treatment protocols.
Assuntos
Coma Diabético/diagnóstico , Coma Diabético/terapia , Coma Hiperglicêmico Hiperosmolar não Cetótico/diagnóstico , Coma Hiperglicêmico Hiperosmolar não Cetótico/terapia , Idoso , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/mortalidade , Dieta para Diabéticos , Feminino , Humanos , Coma Hiperglicêmico Hiperosmolar não Cetótico/mortalidade , Infusões Parenterais , Injeções Intramusculares , Insulina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Sulfonamidas/administração & dosagem , Fatores de TempoRESUMO
Many epidemiological and experimental "in vivo" studies have proved in recent years the carcinogenic properties of herbicides. In order to evaluate the "in vitro" action on the human DNA of Trifluralin, Atrazine and Simazine (active principles of herbicides Treflan and Fogard S respectively) the authors have studied the rates of SCE in cultures of human lymphocytes exposed to different concentrations of a solution 1 ppm of the substances. Trifluralin and Simazine, but not Atrazine, increase SCE per cell, with statistical significance, in the cultures with the highest concentrations of these substances. (SCE per cell: Trifluralin 5.27 +/- 1.38, Simazine 5.09 +/- 1.19, Control 3.51 +/- 1.14).
