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1.
Zhonghua Fu Chan Ke Za Zhi ; 59(5): 346-352, 2024 May 25.
Artigo em Chinês | MEDLINE | ID: mdl-38797563

RESUMO

Objective: To analyze the incidence and clinical phenotype of the concomitant extragenital malformations in the patients with female reproductive tract anomalies. Methods: A retrospective study was conducted using clinical data of hospitalized patients diagnosed with uterine, cervical, or vaginal malformations from January 2003 to December 2022 in Peking Union Medical College Hospital. The malformations were classified according to American Society for Reproductive Medicine müllerian anomalies classification 2021, and in each type, the incidence and specific manifestations of concomitant extragnital malformations were analyzed. Results: A total of 444 patients were included. The overall incidence of concomitant extragenital malformations was 43.5% (193/444), including urinary system, skeletal system, and other system malformations. Renal malformations on the obstructed side were present in all patients with oblique vaginal septum syndrome (100.0%, 78/78). The total incidence of concomitant extragnital malformations was as high as 8/11 in uterus didelphys, 43.5% (10/23) in unicornuate uterus, 33.6% (79/235) in Mayer-Rokitansky-Küster-Hauser syndrome, 18.8% (6/32) in septate uterus and 18.5% (12/65) in cervical agenesis. Urinary system malformations (30.6%, 136/444) and skeletal system malformations (13.5%, 60/444) were the most common concomitant malformations in all types, in which, unilateral renal agenesis and scoliosis were the most common. Conclusions: Urinary and skeletal system malformations are important features of female reproductive tract anomalies. Urologic ultrasonography and spinal roentgenogram are recommended for all patients with female reproductive tract anomalies.


Assuntos
Anormalidades Múltiplas , Ductos Paramesonéfricos , Anormalidades Urogenitais , Útero , Vagina , Humanos , Feminino , Estudos Retrospectivos , Anormalidades Urogenitais/epidemiologia , Útero/anormalidades , Vagina/anormalidades , Ductos Paramesonéfricos/anormalidades , Incidência , Anormalidades Múltiplas/epidemiologia , Transtornos 46, XX do Desenvolvimento Sexual/epidemiologia , Rim/anormalidades , Colo do Útero/anormalidades , Colo do Útero/patologia , Genitália Feminina/anormalidades , China/epidemiologia , Anormalidades Congênitas/epidemiologia , Adulto
2.
Zhonghua Yi Xue Za Zhi ; 104(20): 1852-1859, 2024 May 28.
Artigo em Chinês | MEDLINE | ID: mdl-38782754

RESUMO

Objective: To explore the value of cervical cytologic DNA methylation for screening cervical cancer. Methods: This study was a prospective multicenter study conducted from May to October 2022 in Peking Union Medical College Hospital, Zhejiang Provincial People's Hospital, and the Second Affiliated Hospital of Zhejiang University School of Medicine. Women who accepted opportunistic cervical cancer screening in gynecological outpatient clinics were subjected to liquid-based thin-layer cytology testing (TCT), high-risk human papillomavirus (hrHPV) DNA testing and PAX1/JAM3 dual-genes methylation testing (PAX1m/JAM3m). Colposcopy evaluation and biopsy were offered to women according to current guidelines. The accuracies of various testing methods and their combinations were compared based on histological diagnosis. Results: A total of 1 184 samples diagnosed by histopathology were included in this study, consisting of 541 cases (45.7%) of benign cervical tissue or chronic cervicitis, 273 (23.1%) of cervical intraepithelial neoplasia (CIN) 1, 168 (14.2%) of CIN2, 140 (11.8%) of CIN3, and 62 (5.2%) of cervical cancer. The sensitivity and specificity of PAX1m/JAM3m testing for detecting CIN2 or more severe lesions (CIN2+) were 74.1% and 95.9%, respectively. The sensitivity and specificity of PAX1m/JAM3m testing for detecting CIN3+were 87.6% and 86.8%, respectively. Receiver operating characteristic curve analysis showed that, for detecting CIN3+, the area under curve of PAX1m/JAM3m testing (0.872, 95%CI: 0.847-0.897) was significantly superior to TCT testing (0.580, 95%CI: 0.551-0.610) or hrHPV testing (0.503, 95%CI: 0.479-0.515) (all P values<0.05). Conclusions: The PAX1m/JAM3m test in cervical exfoliated cells has excellent accuracy for the diagnosis of both CIN2+and CIN3+, which is superior to traditional screening protocols and screening strategies.


Assuntos
Metilação de DNA , Detecção Precoce de Câncer , Fatores de Transcrição Box Pareados , Sensibilidade e Especificidade , Displasia do Colo do Útero , Neoplasias do Colo do Útero , Humanos , Feminino , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/genética , Estudos Prospectivos , Fatores de Transcrição Box Pareados/genética , Detecção Precoce de Câncer/métodos , Displasia do Colo do Útero/diagnóstico , Displasia do Colo do Útero/genética , Colposcopia , Colo do Útero/patologia , Programas de Rastreamento/métodos , Papillomaviridae/genética , Papillomaviridae/isolamento & purificação , Adulto
5.
Zhonghua Fu Chan Ke Za Zhi ; 59(1): 1-4, 2024 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-38228510
6.
Zhonghua Fu Chan Ke Za Zhi ; 58(11): 801-803, 2023 Nov 25.
Artigo em Chinês | MEDLINE | ID: mdl-37981764
7.
Zhonghua Fu Chan Ke Za Zhi ; 58(8): 561-564, 2023 Aug 25.
Artigo em Chinês | MEDLINE | ID: mdl-37599252
8.
Zhonghua Fu Chan Ke Za Zhi ; 58(7): 481-484, 2023 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-37474319
9.
Zhonghua Fu Chan Ke Za Zhi ; 58(7): 536-545, 2023 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-37474327

RESUMO

Objective: To evaluate the efficacy and safety of Nocardia rubra cell wall skeleton (Nr-CWS) in the treatment of persistent cervical high-risk human papillomavirus (HR-HPV) infection. Methods: A randomized, double blind, multi-center trial was conducted. A total of 688 patients with clinically and pathologically confirmed HR-HPV infection of the cervix diagnosed in 13 hispital nationwide were recruited and divided into: (1) patients with simple HR-HPV infection lasting for 12 months or more; (2) patients with cervical intraepithelial neoplasia (CIN) Ⅰ and HR-HPV infection lasting for 12 months or more; (3) patients with the same HR-HPV subtype with no CINⅡ and more lesions after treatment with CINⅡ or CIN Ⅲ (CINⅡ/CIN Ⅲ). All participants were randomly divided into the test group and the control group at a ratio of 2∶1. The test group was locally treated with Nr-CWS freeze-dried powder and the control group was treated with freeze-dried powder without Nr-CWS. The efficacy and negative conversion rate of various subtypes of HR-HPV were evaluated at 1, 4, 8, and 12 months after treatment. The safety indicators of initial diagnosis and treatment were observed. Results: (1) This study included 555 patients with HR-HPV infection in the cervix (included 368 in the test group and 187 in the control group), with an age of (44.1±10.0) years. The baseline characteristics of the two groups of subjects, including age, proportion of Han people, weight, composition of HR-HPV subtypes, and proportion of each subgroup, were compared with no statistically significant differences (all P>0.05). (2) After 12 months of treatment, the effective rates of the test group and the control group were 91.0% (335/368) and 44.9% (84/187), respectively. The difference between the two groups was statistically significant (χ2=142.520, P<0.001). After 12 months of treatment, the negative conversion rates of HPV 16, 18, 52, and 58 infection in the test group were 79.2% (84/106), 73.3% (22/30), 83.1% (54/65), and 77.4% (48/62), respectively. The control group were 21.6% (11/51), 1/9, 35.1% (13/37), and 20.0% (8/40), respectively. The differences between the two groups were statistically significant (all P<0.001). (3) There were no statistically significant differences in vital signs (body weight, body temperature, respiration, pulse rate, systolic blood pressure, diastolic blood pressure, etc.) and laboratory routine indicators (blood cell analysis, urine routine examination) between the test group and the control group before treatment and at 1, 4, 8, and 12 months after treatment (all P>0.05); there was no statistically significant difference in the incidence of adverse reactions related to the investigational drug between the two groups of subjects [8.7% (32/368) vs 8.0% (15/187), respectively; χ2=0.073, P=0.787]. Conclusion: External use of Nr-CWS has good efficacy and safety in the treatment of high-risk HPV persistent infection in the cervix.


Assuntos
Infecções por Papillomavirus , Displasia do Colo do Útero , Neoplasias do Colo do Útero , Feminino , Humanos , Adulto , Pessoa de Meia-Idade , Colo do Útero/patologia , Neoplasias do Colo do Útero/patologia , Infecções por Papillomavirus/diagnóstico , Esqueleto da Parede Celular , Infecção Persistente , Pós , Displasia do Colo do Útero/patologia , Imunoterapia , Papillomaviridae
10.
12.
Zhonghua Fu Chan Ke Za Zhi ; 58(1): 1-3, 2023 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-36720609

Assuntos
Medicina , Humanos
13.
Zhonghua Fu Chan Ke Za Zhi ; 57(12): 889-890, 2022 12 25.
Artigo em Chinês | MEDLINE | ID: mdl-36562221

Assuntos
Medicina , Humanos
19.
Zhonghua Fu Chan Ke Za Zhi ; 57(1): 1-2, 2022 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-37193589
20.
Zhonghua Fu Chan Ke Za Zhi ; 56(12): 809-811, 2021 12 25.
Artigo em Chinês | MEDLINE | ID: mdl-34954957
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