RESUMO
PURPOSE: This double-blind placebo-controlled trial evaluated serum 25-hydroxyvitamin D [25(OH)D] levels after the oral intake of a single dose of cholecalciferol during one of the three meals, containing different amounts of fat or placebo. METHODS AND RESULTS: Sixty-four healthy medical residents or students of a university hospital in Porto Alegre, latitude 30° S, Brazil, were divided into four groups. Three groups received a single 50,000 IU oral dose of cholecalciferol during a meal containing 0 g (Group 1), 15 g (Group 2) or 30 g (Group 3) of fat, and one group received placebo (Group 4), according to randomization. Serum 25(OH)D, parathyroid hormone, total calcium, albumin, magnesium, and creatinine levels, and urinary calcium, magnesium, and creatinine levels were measured at baseline and after 14 days. Baseline mean serum 25(OH)D levels were low in all groups. Vitamin D given during breakfast increased the mean change of serum 25(OH)D levels, when compared to placebo. Furthermore, the intake of fat with vitamin D increased the mean change of serum 25(OH)D levels. CONCLUSION: A single oral dose of vitamin D given with food increased mean serum 25(OH)D levels, after 2 weeks, and the mean increase was larger, when the meal had at least 15 g of fat. These findings can have important implications to oral vitamin D supplementation.
Assuntos
Gorduras na Dieta/administração & dosagem , Vitamina D/administração & dosagem , Vitamina D/sangue , Administração Oral , Adulto , Brasil , Desjejum , Cálcio/sangue , Cálcio/urina , Creatinina/sangue , Creatinina/urina , Suplementos Nutricionais , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Humanos , Magnésio/sangue , Magnésio/urina , Masculino , Hormônio Paratireóideo/sangue , Albumina Sérica/metabolismo , Adulto JovemRESUMO
Os autores relatam o caso de uma paciente portadora de esporotricose cutâneo-linfática, com comprometimento de antebraço e braço direitos. Tratada com droga específica (itraconazol) e acompanhada durante seis meses, obteve a cura ao final do tratamento, persistindo apenas as cicatrizes das lesões.
A clinical case of a patiente bearing cutaneous-lymphatic sporotrichosis with right forearm and arm involvement is presented. She was treated with specific drug (itraconazole) and followed a 6-months and she got the cure in the end of the treatment persisting only the scars of the injuries.
