1.
J Org Chem
; 76(1): 297-300, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21133352
RESUMO
Diastereoselective hydrogenation of 2'-deoxy-2'-exo-methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.